scholarly journals Ochronotic Arthropathy: Two Case Reports from a Developing Country

2016 ◽  
Vol 9 ◽  
pp. CMAMD.S31560 ◽  
Author(s):  
Farooq A. Rathore ◽  
Saeed B. Ayaz ◽  
Sahibzada N. Mansoor
Keyword(s):  
Case Reports ◽  
Symptomatic Improvement ◽  
Intervertebral Disk ◽  
The Body ◽  
High Dose ◽  
Ochronotic Arthropathy ◽  
Intervertebral Disks ◽  
First Case ◽  
Lost To Follow Up

Alkaptonuria is a rare inborn error of metabolism, which is classified as an orphan disease. It is due to the lack of an enzyme homogentisate 1,2-dioxygenase, which results in an accumulation of homogentisic acid in different areas of the body, including sclera, skin, cardiac valves, articular cartilage of the large joints and intervertebral disks. We present two cases of alkaptonuria resulting in ochronotic arthropathy with advanced secondary generalized osteoarthritis, intervertebral disk calcifications, skin and scleral pigmentation. In these case reports, both patients had symptoms for >10 years before being diagnosed. Conservative management in the form of high-dose ascorbic acid, exercises, and gait aids was offered to both of them, which resulted in some symptomatic improvement in the first case, while the second case was lost to follow-up. Alkaptonuria is a rare disease, and although it does not clearly impact mortality, early diagnosis may improve the quality of life.

scholarly journals Intranasal Ectopic Tooth in Adult and Pediatric Patients: A Report of Two Cases

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Isabela Polesi Bergamaschi ◽  
Bernardo Olsson ◽  
Aline Monise Sebastiani ◽  
Guilherme dos Santos Trento ◽  
Nelson Luis Barbosa Rebellato ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Case Reports ◽  
Facial Trauma ◽  
Surgical Removal ◽  
Safe Procedure ◽  
Main Complaint ◽  
First Case ◽  
Ectopic Tooth

The aim of this study was to report two rare cases of ectopic tooth into the nasal cavity. The first case reports a 32-year-old female patient with the main complaint of having a tooth inside her nose. According to her, this condition causes pain and sporadic nosebleed. The patient had a facial trauma when she was 6 years old. The second case refers to an 8-year-old girl with left incomplete unilateral cleft lip and palate. The main complaint was left-sided nasal obstruction by a white hard mass. The treatment for both cases was surgical removal of the ectopic erupted tooth under general anesthesia. In conclusion, we can state that the surgical removal of intranasal tooth is a safe procedure and improves patient’s quality of life.

Bone Marrow Necrosis

1995 ◽  
Vol 10 (4) ◽  
pp. 171-178 ◽  
Author(s):  
Marcel E. Conrad
Keyword(s):  
Bone Marrow ◽  
Cancer Chemotherapy ◽  
Case Reports ◽  
Blood Stasis ◽  
Pathological Finding ◽  
Vascular Occlusion ◽  
High Dose ◽  
Bone Marrow Necrosis ◽  
Clinical Illness ◽  
Lost To Follow Up

Bone marrow necrosis is regarded as an uncommon entity that is associated with a poor prognosis. However, organized studies using either bone marrow biopsy specimens or autopsy material showed that bone marrow necrosis can be demonstrated in approximately one third of specimens. It is found in a large number of both malignant and nonmalignant disorders, in addition to occurring following large exposures to radiation or high dose cancer chemotherapy. In the absence of radiation or cancer chemotherapy, it probably eventuates from either vascular occlusion or blood stasis in small blood vessels. When bone marrow necrosis is prolonged, it may be associated with the development of bone marrow fibrosis, and it may serve as a predisposing etiology for idiopathic myelofibrosis. Most patients discovered with bone marrow necrosis have few symptoms, and they are eventually lost to follow-up without evident progression or development of a clinical illness. In acute disorders and in those who undergo effective therapy, recovery appears to occur without complications. This frequently overlooked finding is the subject of many case reports in the medical literature, but it has only been rarely systematically investigated. The latter is probably warranted because of the potential role of bone marrow necrosis in the pathophysiology of a number of disorders and the paucity of information for treatment of this pathological finding.

Risperidone in the treatment of psychoses in the elderly: a case report series

2002 ◽  
Vol 17 (2) ◽  
pp. 96-103 ◽  
Author(s):  
R. Bullock ◽  
S. Libretto
Keyword(s):  
Side Effects ◽  
Elderly Patients ◽  
Negative Symptoms ◽  
Case Reports ◽  
Antipsychotic Agents ◽  
The Elderly ◽  
The Body ◽  
Continuous Treatment ◽  
Atypical Antipsychotic Agents

SummaryRisperidone is one of the newer atypical antipsychotic agents, which combines potent serotonin and dopamine receptor antagonism. It shows efficacy against the positive and negative symptoms of schizophrenic psychoses and other psychotic conditions, and has a low propensity to cause extrapyramidal side effects. The aim of these case reports in elderly patients is to provide the benefit of personal experience with risperidone to the body of published literature and to demonstrate the types of patients that may benefit from treatment. These cases were compiled retrospectively from data collected on referral and during routine hospital appointments. This series covers four main areas of concern when treating the elderly: low-maintenance dosing minimising the likelihood of adverse events; successful treatment of patients previously uncontrolled and experiencing side effects with other antipsychotics; the possibility of intermittent rather than continuous treatment; and the benefits to patients, carers and the health services. At low doses, risperidone is an effective and well-tolerated treatment for psychoses in elderly patients that improves the quality of life for both patients and their caregivers.

Psychopharmacological options for adult patients with anorexia nervosa

CNS Spectrums ◽  
2015 ◽  
Vol 21 (2) ◽  
pp. 134-142 ◽  
Author(s):  
Mario Miniati ◽  
Mauro Mauri ◽  
Agnese Ciberti ◽  
Michela Giorgi Mariani ◽  
Donatella Marazziti ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Sample Size ◽  
Case Reports ◽  
Case Series ◽  
The Body ◽  
Adult Patients ◽  
Drug Classes

The aim of this review was to summarize evidence from research on psychopharmacological options for adult patients with anorexia nervosa (AN). Database searches of MEDLINE and PsycINFO (from January 1966 to January 2014) were performed, and original articles published as full papers, brief reports, case reports, or case series were included. Forty-one papers were screened in detail, and salient characteristics of pharmacological options for AN were summarized for drug classes. The body of evidence for the efficacy of pharmacotherapy in AN was unsatisfactory, the quality of observations was questionable (eg, the majority were not blinded), and sample size was often small. More trials are needed, while considering that nonresponse and nonremission are typical of patients with AN.

scholarly journals Everolimus Implicated in Case of Severe Gastrointestinal Hemorrhage

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Paul Gonzales ◽  
Seth Klusewitz ◽  
Johanna Marowske ◽  
John Gancayco ◽  
Michael B. Osswald ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gastrointestinal Bleeding ◽  
Case Reports ◽  
Argon Plasma Coagulation ◽  
Mammalian Target Of Rapamycin ◽  
Argon Plasma ◽  
Metastatic Breast ◽  
Reduced Dose ◽  
First Case

Breast cancer remains the leading cause of cancer and the third leading cause of cancer related deaths among our population with an estimated number of 246,660 new cases and 40,450 deaths in 2016. With treatment advancements, including targeted agents such as Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, survivability and quality of life continue to improve. However, with the use of these agents come adverse effects, some of which are still being characterized. Our case demonstrates recurrent episodes of gastrointestinal bleeding in a 60-year-old woman being treated with Everolimus for progressive metastatic breast cancer. On endoscopy, bleeding was secondary to erosive gastritis. Previous case reports have described bleeding due to gastric antral vascular ectasia (GAVE), which was described in two prior reported cases. In our case, bleeding also occurred on a reduced dose of Everolimus compared to what is previously reported (5 mg versus 10 mg). As a result of her gastrointestinal bleeding, she required multiple endoscopic interventions including argon plasma coagulation and multipolar heater probe to achieve hemostasis. This is the first case reported of gastrointestinal bleeding not consistent with GAVE and occurring while being on a reduced dose of Everolimus. It is important to document our case so that the Gastroenterology and Hematology communities can be educated and made aware for their patient populations on Everolimus.

scholarly journals Three Cases of Insomnia in Herniated Intervertebral Disk Patients Treated with Uhwangchungsim-won

2021 ◽  
Vol 42 (5) ◽  
pp. 767-776
Author(s):  
Ji-eun Bae ◽  
Gyu-cheol Choi ◽  
Jae-won Park ◽  
Dong-jin Kim ◽  
Jeong-su Hong ◽  
...  
Keyword(s):  
Rating Scale ◽  
Numerical Rating Scale ◽  
Intervertebral Disk ◽  
Five Dimensions ◽  
Subjective Sleep ◽  
Beneficial Effects ◽  
Intervertebral Disks ◽  
Numerical Rating ◽  
Medical Therapies

Objective: This study examined a case in which insomnia and pain due to herniated intervertebral disks were improved by treatment with an oriental herbal and the administration of Uhwangchungsim-won.Case Summary: Three patients with insomnia diagnosed with herniated intervertebral disks were treated with a series of Korean medical therapies, including the herbal medication Uhwangchungsim-won, acupuncture, herbal acupuncture, and physical therapy. We used the Numerical Rating Scale (NRS) to measure subjective sleep states and the European Quality of Life Five Dimensions (EQ-5d) Scale to evaluate the therapeutic effect. Following treatment, subjective sleep states and the overall scores for pain had improved.Conclusion: The results indicate that Korean medical therapies with Uhwangchungsim-won have beneficial effects on insomnia for patients with herniated intervertebral disks.

scholarly journals Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
C. Müller ◽  
H. Reuter ◽  
C. Dohmen
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Case Report ◽  
Psychotic Disorders ◽  
Case Reports ◽  
Gastric Lavage ◽  
High Dose ◽  
Airway Protection ◽  
Residual Symptoms ◽  
First Case

Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia,QTc-prolongation, somnolence, and hyperglycemia. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide. Symptoms associated with intoxication were coma without arterial hypotension, persistent tachycardia, hyperglycemia, and transient hypothyreoidism.QTc-interval was moderately extended. Management consisted of intubation for airway protection, gastric lavage, the use of activated charcoal, i.v. saline, and observation for 17 hours on an intensive care unit. Despite the extremely high dose of quetiapine, the patient recovered completely without residual symptoms.

scholarly journals Calcanectomy, an Alternative Amputation? Two Case Reports

2009 ◽  
Vol 33 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Jan H. B. Geertzen ◽  
Paul Jutte ◽  
Christiaan Rompen ◽  
Merse Salvans
Keyword(s):  
Spina Bifida ◽  
Case Reports ◽  
Traumatic Experience ◽  
Limb Amputation ◽  
Mortality And Morbidity ◽  
First Case ◽  
Spina Bifida Aperta ◽  
Alternative Type ◽  
The Right

A limb amputation is a traumatic experience for the amputee but it is also a challenge for the recipient to get used to a new situation and reach her/his greatest level of independence. Two patients are presented who had undergone a total calcanectomy. In the first case, a woman with spina bifida aperta L4-L5, calcanectomy was performed to excise a non-healing ulcer and osteomyelitis of the right heel. In the second case, a woman of 72 years of age, calcanectomy was the treatment of the isolated central chondrosarcoma. Both patients were somewhat disabled prior to calcanectomy, one because of spina bifida aperta and the other because of her age. After calcanectomy both patients were able to remain independent for several years. Calcanectomy is an uncommon amputation that may provide better quality of life than other more proximal amputations such as Syme or transtibial amputation. Furthermore more proximal levels of amputation are associated with increased mortality and morbidity. When indicated, calcanectomy should be considered as an alternative type of amputation which provides an effective chance to maintain the patient's independency.

scholarly journals Foreign Accent Syndrome Secondary to Medication Withdrawal: A Case Report

2017 ◽  
Vol 8 (3) ◽  
pp. 5
Author(s):  
Michael J. Schuh
Keyword(s):  
Case Report ◽  
Conflicts Of Interest ◽  
Case Reports ◽  
High Amplitude ◽  
Foreign Accent ◽  
Caucasian Woman ◽  
High Dose ◽  
First Case ◽  
Foreign Accent Syndrome ◽  
Psychotic Exacerbation

Objective: The purpose of this case report is to demonstrate a possible alternative etiology related to dopamine may exist for foreign accent syndrome (FAS). Methods: A 79-year-old, 205 pound, Caucasian woman originally presented to the department of Neurology for treatment and subsequently to the pharmacist pharmacotherapy service for evaluation of bilateral upper extremity tremor of high amplitude but was found to also exhibit FAS. Discussion: This case report contributes to the limited literature regarding foreign accent syndrome and adds to the few case reports of psychogenic origin, as opposed to the majority, which are of neurogenic origin. This also represents the first case that seems related to withdrawal of medication rather than psychotic exacerbation and ranks a six on the Naranjo algorithm. Conclusion: FAS is a rare disorder and little is understood about it. This case presentation also suggests that chronic use of high-dose dopamine and/or anticholinergic agents may alter pathways in the brain, which in this case, may have potentially contributed to the development of FAS. There remain many unanswered questions regarding FAS, but hopefully more clarity may be found as more cases are discovered and published. Conflict of Interest I declare no conflicts of interest or financial interests that the authors or members of their immediate families have in any product or service discussed in the manuscript, including grants (pending or received), employment, gifts, stock holdings or options, honoraria, consultancies, expert testimony, patents and royalties.   Type: Case Study

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