scholarly journals Integrated in silico-in vitro characterization, identification and disruption of the intermolecular interaction between SH3 domain-containing protein kinases and human pituitary tumor-transforming gene 1

2017 ◽  
Vol 36 (01) ◽  
pp. 91-98 ◽  
Author(s):  
Yanan Li ◽  
Mengmeng Li ◽  
Weijie Min ◽  
Guosheng Han ◽  
Laixing Wang ◽  
...  
Keyword(s):  
Intermolecular Interaction ◽  
Protein Kinases ◽  
In Silico ◽  
Pituitary Tumor ◽  
Sh3 Domain ◽  
Human Pituitary ◽  
In Vitro Characterization ◽  
Transforming Gene ◽  
Human Pituitary Tumor

Structure, Expression, and Function of Human Pituitary Tumor-Transforming Gene (PTTG)

1999 ◽  
Vol 13 (1) ◽  
pp. 156-166 ◽  
Author(s):  
Xun Zhang ◽  
Gregory A. Horwitz ◽  
Toni R. Prezant ◽  
Alberto Valentini ◽  
Masahiro Nakashima ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pituitary Tumor ◽  
Fibroblast Growth ◽  
3T3 Cells ◽  
Human Pituitary ◽  
Nih 3T3 ◽  
Transforming Gene ◽  
Human Pituitary Tumor

Abstract Despite advances in characterizing the pathophysiology and genetics of pituitary tumors, molecular mechanisms of their pathogenesis are poorly understood. Recently, we isolated a transforming gene [pituitary tumor-transforming gene (PTTG)] from rat pituitary tumor cells. Here we describe the cloning of human PTTG, which is located on chromosome 5q33 and shares striking sequence homology with its rat counterpart. Northern analysis revealed PTTG expression in normal adult testis, thymus, colon, small intestine, brain, lung, and fetal liver, but most abundant levels of PTTG mRNA were observed in several carcinoma cell lines. Stable transfection of NIH 3T3 cells with human PTTG cDNA caused anchorage-independent transformation in vitro and induced in vivo tumor formation when transfectants were injected into athymic mice. Overexpression of PTTG in transfected NIH 3T3 cells also stimulated expression and secretion of basic fibroblast growth factor, a human pituitary tumor growth-regulating factor. A proline-rich region, which contains two PXXP motifs for the SH3 domain-binding site, was detected in the PTTG protein sequence. When these proline residues were changed by site-directed mutagenesis, PTTG in vitro transforming and in vivo tumor-inducing activity, as well as stimulation of basic fibroblast growth factor, was abrogated. These results indicate that human PTTG, a novel oncogene, may function through SH3-mediated signal transduction pathways and activation of growth factor(s).

Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization

Gene ◽  
2000 ◽  
Vol 248 (1-2) ◽  
pp. 41-50 ◽  
Author(s):  
Leilei Chen ◽  
Rashmi Puri ◽  
Elliot J. Lefkowitz ◽  
Sham S. Kakar
Keyword(s):  
Molecular Structure ◽  
Pituitary Tumor ◽  
Chromosomal Localization ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor

scholarly journals Human Pituitary Tumor Transforming Gene (hPTTG) Inhibits Human Lung Cancer A549 Cell Growth through Activation of p21WAF1/CIP1

2003 ◽  
Vol 50 (6) ◽  
pp. 771-781 ◽  
Author(s):  
Yi-Ming MU ◽  
Koichi OBA ◽  
Toshihiko YANASE ◽  
Takeshi ITO ◽  
Kenji ASHIDA ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
A549 Cell ◽  
Pituitary Tumor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Human Pituitary ◽  
Transforming Gene ◽  
Lung Cancer A549 Cell ◽  
Human Pituitary Tumor

Histone acetyltransferase p300 regulates the expression of human pituitary tumor transforming gene (hPTTG)

2009 ◽  
Vol 36 (6) ◽  
pp. 335-342 ◽  
Author(s):  
Tian Li ◽  
Hui Huang ◽  
Binlu Huang ◽  
Baiqu Huang ◽  
Jun Lu
Keyword(s):  
Pituitary Tumor ◽  
Histone Acetyltransferase ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor ◽  
Acetyltransferase P300

scholarly journals Human Pituitary Tumor-Transforming Gene (PTTG1) Motif Suppresses Prolactin Expression

2003 ◽  
Vol 17 (4) ◽  
pp. 600-609 ◽  
Author(s):  
Gregory A. Horwitz ◽  
Irina Miklovsky ◽  
Anthony P. Heaney ◽  
Song-Guang Ren ◽  
Shlomo Melmed
Keyword(s):  
Pituitary Tumor ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor

scholarly journals Human Pituitary Tumor-Transforming Gene Induces Angiogenesis1

2001 ◽  
Vol 86 (2) ◽  
pp. 867-874 ◽  
Author(s):  
Hiroki Ishikawa ◽  
Anthony P. Heaney ◽  
Run Yu ◽  
Gregory A. Horwitz ◽  
Shlomo Melmed
Keyword(s):  
Pituitary Tumor ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor

scholarly journals Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells

2012 ◽  
Vol 14 (4) ◽  
Author(s):  
Jhen-Wei Ruan ◽  
Yi-Chu Liao ◽  
Ingrid Lua ◽  
Ming-Hsun Li ◽  
Chih-Yi Hsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Pituitary Tumor ◽  
Breast Cancer Cells ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor
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