Top-down analytical platforms for the characterization of the human salivary proteome

Bioanalysis ◽  
2014 ◽  
Vol 6 (4) ◽  
pp. 563-581 ◽  
Author(s):  
Tiziana Cabras ◽  
Federica Iavarone ◽  
Barbara Manconi ◽  
Alessandra Olianas ◽  
Maria Teresa Sanna ◽  
...  
Author(s):  
Dirk Doyle ◽  
Lawrence Benedict ◽  
Fritz Christian Awitan

Abstract Novel techniques to expose substrate-level defects are presented in this paper. New techniques such as inter-layer dielectric (ILD) thinning, high keV imaging, and XeF2 poly etch overflow are introduced. We describe these techniques as applied to two different defects types at FEOL. In the first case, by using ILD thinning and high keV imaging, coupled with focused ion beam (FIB) cross section and scanning transmission electron microscopy (STEM,) we were able to judge where to sample for TEM from a top down perspective while simultaneously providing the top down images giving both perspectives on the same sample. In the second case we show retention of the poly Si short after removal of CoSi2 formation on poly. Removal of the CoSi2 exposes the poly Si such that we can utilize XeF2 to remove poly without damaging gate oxide to reveal pinhole defects in the gate oxide. Overall, using these techniques have led to 1) increased chances of successfully finding the defects, 2) better characterization of the defects by having a planar view perspective and 3) reduced time in localizing defects compared to performing cross section alone.


2014 ◽  
Vol 406 ◽  
pp. 1-7 ◽  
Author(s):  
Mildred A. Airo ◽  
Siziwe Gqoba ◽  
Mubiayi P. Kalenga ◽  
Stefan Govindraju ◽  
Makwena J. Moloto ◽  
...  

2018 ◽  
Vol 57 (4) ◽  
pp. 573-587 ◽  
Author(s):  
Daniel Gamper Sachse

Most of the Spanish media have portrayed Catalan independentism as nationalism and populism. This article argues that this political and social mobilization does not fit into the usual definitions of populism as anti-elitist, anti-liberal and anti-pluralistic movement. Catalan independentism is here interpreted by stressing its democratic features, namely as a form of democratic populism: horizontally organized, and critical of procedural safeguards and counter-majoritarian powers. The popular organization of the referendum on 1 October 2017 and the vigorous democratic experience by almost half of the population of Catalonia allow for a characterization of this populism as a hybrid phenomenon that includes bottom-up and top-down dynamics, thereby contrasting with the usual leader-centred understanding of populism.


2010 ◽  
pp. P3-342-P3-342
Author(s):  
D. Milardi ◽  
G. Grande ◽  
F. Vincenzoni ◽  
A. Giampietro ◽  
A. Bianchi ◽  
...  

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 630
Author(s):  
Daniela Madama ◽  
Rosana Martins ◽  
Ana S. Pires ◽  
Maria F. Botelho ◽  
Marco G. Alves ◽  
...  

Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable challenges posed by this disease are the diagnosis of 61% of patients in advanced stages and the reduced five-year survival rate of around 4%. Noninvasively collected samples are gaining significant interest as new areas of knowledge are being sought and opened up. Metabolomics is one of these growing areas. In recent years, the use of metabolomics as a resource for the study of lung cancer has been growing. We conducted a systematic review of the literature from the past 10 years in order to identify some metabolites associated with lung cancer. More than 150 metabolites have been associated with lung cancer-altered metabolism. These were detected in different biological samples by different metabolomic analytical platforms. Some of the published results have been consistent, showing the presence/alteration of specific metabolites. However, there is a clear variability due to lack of a full clinical characterization of patients or standardized patients selection. In addition, few published studies have focused on the added value of the metabolomic profile as a means of predicting treatment response for lung cancer. This review reinforces the need for consistent and systematized studies, which will help make it possible to identify metabolic biomarkers and metabolic pathways responsible for the mechanisms that promote tumor progression, relapse and eventually resistance to therapy.


2018 ◽  
Vol 17 (9) ◽  
pp. 3292-3307 ◽  
Author(s):  
Alessandra Padiglia ◽  
Roberto Orrù ◽  
Mozhgan Boroumand ◽  
Alessandra Olianas ◽  
Barbara Manconi ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Franziska Wohlgemuth ◽  
Rachel L. Gomes ◽  
Ian Singleton ◽  
Frankie J. Rawson ◽  
Simon V. Avery
Keyword(s):  

2013 ◽  
Vol 36 (17) ◽  
pp. 2848-2861 ◽  
Author(s):  
Tiziana Cabras ◽  
Federica Iavarone ◽  
Davide Pirolli ◽  
Maria Cristina De Rosa ◽  
Alberto Vitali ◽  
...  

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