scholarly journals Anomeric DNA quadruplexes

2014 ◽  
Vol 5 (2) ◽  
pp. e28422 ◽  
Author(s):  
Natalia A Kolganova ◽  
Anna M Varizhuk ◽  
Roman A Novikov ◽  
Vladimir L Florentiev ◽  
Galina E Pozmogova ◽  
...  
Keyword(s):  
Dna Quadruplexes

scholarly journals Binding and Partial Denaturing of G-quartet DNA by Cdc13p ofSaccharomyces cerevisiae

2001 ◽  
Vol 276 (50) ◽  
pp. 47671-47674 ◽  
Author(s):  
Yi-Chien Lin ◽  
Jing-Wen Shih ◽  
Chia-Ling Hsu ◽  
Jing-Jer Lin
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Intermolecular Association ◽  
Telomere Association ◽  
Dna Quadruplex ◽  
Telomere Replication ◽  
Dna Quadruplexes

The protein Cdc13p binds telomeresin vivoand is essential for the maintenance of the telomeres ofSaccharomyces cerevisiae. In addition, Cdc13p is known to bind single-stranded TG1–3DNAin vitro. Here we have shown that Cdc13p also binds DNA quadruplex, G-quartet, formed by TG1–3DNA. Moreover, the binding of Cdc13p causes a partial denaturing of the G-quartet DNA. Formation of DNA quadruplexes may involve the intermolecular association of TG1–3DNA and inhibit the extension of telomeres by telomerase. Thus, our finding suggests that Cdc13p may disrupt telomere association and facilitate telomere replication.

scholarly journals Voltammetry and molecular assembly of G-quadruplex DNAzyme on single-crystal Au(111)-electrode surfaces – hemin as an electrochemical intercalator

2016 ◽  
Vol 193 ◽  
pp. 99-112 ◽  
Author(s):  
Ling Zhang ◽  
Jens Ulstrup ◽  
Jingdong Zhang
Keyword(s):  
Single Crystal ◽  
Single Molecule ◽  
Electrode Surface ◽  
Molecular Assembly ◽  
Electrode Surfaces ◽  
Potential Control ◽  
G Quadruplex ◽  
Tunnelling Microscopy ◽  
Dna Quadruplexes

DNA quadruplexes (qs) are a class of “non-canonical” oligonucleotides (OGNs) composed of stacked guanine (G) quartets stabilized by specific cations. Metal porphyrins selectively bind to G-qs complexes to form what is known as DNAzyme, which can exhibit peroxidase and other catalytic activity similar to heme group metalloenzymes. In the present study we investigate the electrochemical properties and the structure of DNAzyme monolayers on single-crystal Au(111)-electrode surfaces using cyclic voltammetry and scanning tunnelling microscopy under electrochemical potential control (in situ STM). The target DNAzyme is formed from a single-strand OGN with 12 guanines and iron(iii) porphyrin IX (hemin), and assembles on Au(111) through a mercapto alkyl linker. The DNAzyme monolayers exhibit a strong pair of redox peaks at 0.0 V (NHE) at pH 7 in acetate buffer, shifted positively by about 50 mV compared to free hemin weakly physisorbed on the Au(111)-electrode surface. The voltammetric hemin signal of DNAzyme is enhanced 15 times compared with that of hemin adsorbed directly on the Au(111)-electrode surface. This is indicative of both the formation of a close to dense DNAzyme monolayer and that hemin is strongly bound to the immobilized 12G-qs in well-defined orientation favorable for interfacial ET with a rate constant of 6.0 ± 0.4 s−1. This is supported by in situ STM which discloses single-molecule G-quartet structures with a size of 1.6 ± 0.2 nm.

scholarly journals Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives

2020 ◽  
Vol 19 (4) ◽  
pp. 436-444 ◽  
Author(s):  
Lara Martínez-Fernández ◽  
Luciana Esposito ◽  
Roberto Improta
Keyword(s):  
Electronic States ◽  
Quantum Mechanical ◽  
Excited Electronic States ◽  
Mechanical Methods ◽  
Dna Quadruplexes

Calculations are providing more and more useful insights into the interaction between light and DNA quadruplexes.

scholarly journals Kinetic Stability of Intermolecular DNA Quadruplexes

2005 ◽  
Vol 89 (1) ◽  
pp. 365-373 ◽  
Author(s):  
Elena E. Merkina ◽  
Keith R. Fox
Keyword(s):  
Kinetic Stability ◽  
Dna Quadruplexes

Cytosine-cytosine+ base pairing stabilizes DNA quadruplexes and cytosine methylation greatly enhances the effect

Biochemistry ◽  
1993 ◽  
Vol 32 (22) ◽  
pp. 5870-5880 ◽  
Author(s):  
Charles C. Hardin ◽  
Matthew Corregan ◽  
Bernard A. Brown ◽  
Lori N. Frederick
Keyword(s):  
Cytosine Methylation ◽  
Base Pairing ◽  
Dna Quadruplexes

scholarly journals Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates

2009 ◽  
Vol 7 (1) ◽  
pp. 76-84 ◽  
Author(s):  
James E. Redman ◽  
J. M. Granadino-Roldán ◽  
James A. Schouten ◽  
Sylvain Ladame ◽  
Anthony P. Reszka ◽  
...  
Keyword(s):  
Peptide Conjugates ◽  
Dna Quadruplexes

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

2009 ◽  
pp. 7482 ◽  
Author(s):  
Gavin Collie ◽  
Anthony P. Reszka ◽  
Shozeb M. Haider ◽  
Valérie Gabelica ◽  
Gary N. Parkinson ◽  
...  
Keyword(s):  
Small Molecule ◽  
Dna Quadruplexes ◽  
Rna And Dna ◽  
Telomeric Rna

Digital Analysis of Protein Properties by an Ensemble of DNA Quadruplexes

2009 ◽  
Vol 131 (26) ◽  
pp. 9142-9143 ◽  
Author(s):  
David Margulies ◽  
Andrew D. Hamilton
Keyword(s):  
Digital Analysis ◽  
Protein Properties ◽  
Dna Quadruplexes

scholarly journals Structure and stability of DNA quadruplexes under molecular crowding conditions

2005 ◽  
Vol 49 (1) ◽  
pp. 239-240 ◽  
Author(s):  
Hisae Karimata ◽  
Daisuke Miyoshi ◽  
Naoki Sugimoto
Keyword(s):  
Molecular Crowding ◽  
Structure And Stability ◽  
Dna Quadruplexes
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