Is Classification of Gastric Cancer According to Distinct Therapeutic Targets Applicable in Clinical Practice?

Aim:The authors present the Cotard's syndrome, a rare psychiatric condition, pointing out the latest results in terms of psychoneurology and classification of the phenomenon. The central feature of the syndrome is a nihilistic delusion, in which the patient denies his or her own existence and that of the external world.Method:We searched electronic scientific databases using the appropriate search terms; relevant articles were carefully reviewed. We also present three cases from our clinical practice.Results:After the overview of the latest biological and neuropsychological findings, the terminology, the nosology, the classification and the differential diagnostics are discussed. To sum up with useful information for the clinical practice, the possible treatment strategies, the course and the prognosis of the disease are also presented.Conclusions:The reported cases together with the reviewed literature suggest that a dimensional system of classifying Cotard's syndrome is preferable. At the one end of the spectrum is the presence of the pure nihilistic delusions, appearing as a symptom of an underlying psychiatric or neurological condition. The full-blown, classical syndrome as a diagnostic category forms the other end of the spectrum. The presented theoretical and practical aspects give a lead on deeper understanding, easier recognition and more adequate therapy of the Cotard's syndrome.

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Intestinal bacteria are potential biomarkers and therapeutic targets for gastric cancer

Microbial Pathogenesis ◽

10.1016/j.micpath.2021.104747 ◽

2021 ◽

Vol 151 ◽

pp. 104747

Author(s):

Shili Liu ◽

Jianjian Dai ◽

Xiang Lan ◽

Bingbing Fan ◽

Tianyi Dong ◽

...

Keyword(s):

Gastric Cancer ◽

Therapeutic Targets ◽

Intestinal Bacteria ◽

Potential Biomarkers

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Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review

Biomedicines ◽

10.3390/biomedicines9030310 ◽

2021 ◽

Vol 9 (3) ◽

pp. 310

Author(s):

Yuta Tezuka ◽

Yuto Yamazaki ◽

Yasuhiro Nakamura ◽

Hironobu Sasano ◽

Fumitoshi Satoh

Keyword(s):

Clinical Practice ◽

Primary Aldosteronism ◽

Diagnostic Procedures ◽

Secondary Hypertension ◽

Refractory Hypertension ◽

Diagnostic Biomarkers ◽

Histopathological Classification ◽

Subtype Differentiation ◽

Work Up

For the last seven decades, primary aldosteronism (PA) has been gradually recognized as a leading cause of secondary hypertension harboring increased risks of cardiovascular incidents compared to essential hypertension. Clinically, PA consists of two major subtypes, surgically curable and uncurable phenotypes, determined as unilateral or bilateral PA by adrenal venous sampling. In order to further optimize the treatment, surgery or medications, diagnostic procedures from screening to subtype differentiation is indispensable, while in the general clinical practice, the work-up rate is extremely low even in the patients with refractory hypertension because of the time-consuming and labor-intensive nature of the procedures. Therefore, a novel tool to simplify the diagnostic flow has been recently in enormous demand. In this review, we focus on recent progress in the following clinically important topics of PA: prevalence of PA and its subtypes, newly revealed histopathological classification of aldosterone-producing lesions, novel diagnostic biomarkers and prediction scores. More effective strategy to diagnose PA based on better understanding of its epidemiology and pathology should lead to early detection of PA and could decrease the cardiovascular and renal complications of the patients.

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Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic gastric cancer: a JSMO–ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS

Annals of Oncology ◽

10.1093/annonc/mdy502 ◽

2019 ◽

Vol 30 (1) ◽

pp. 19-33 ◽

Cited By ~ 47

Author(s):

K. Muro ◽

E. Van Cutsem ◽

Y. Narita ◽

G. Pentheroudakis ◽

E. Baba ◽

...

Keyword(s):

Gastric Cancer ◽

Clinical Practice ◽

Clinical Practice Guidelines ◽

Practice Guidelines ◽

Metastatic Gastric Cancer

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Mechanisms of Atrial Fibrillation – Reentry, Rotors and Reality

Arrhythmia & Electrophysiology Review ◽

10.15420/aer.2014.3.2.90 ◽

2014 ◽

Vol 3 (2) ◽

pp. 90 ◽

Cited By ~ 26

Author(s):

Jonathan W Waks ◽

Mark E Josephson ◽

◽

Keyword(s):

Atrial Fibrillation ◽

Clinical Practice ◽

Catheter Ablation ◽

20Th Century ◽

Experimental Studies ◽

Therapeutic Targets ◽

Spiral Waves ◽

Historical Understanding ◽

New Strategies ◽

Complex Fractionated Atrial Electrograms

Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, yet our understanding of the mechanisms that initiate and sustain this arrhythmia remains quite poor. Over the last 50 years, various mechanisms of AF have been proposed, yet none has been consistently observed in both experimental studies and in humans. Recently, there has been increasing interest in understanding how spiral waves or rotors – which are specific, organised forms of functional reentry – sustain human AF and how they might be therapeutic targets for catheter-based ablation. The following review describes the historical understanding of reentry and AF mechanisms from earlier in the 20th century, advances in our understanding of mechanisms that are able to sustain AF with a focus on rotors and complex fractionated atrial electrograms (CFAEs), and how the study of AF mechanisms has resulted in new strategies for treating AF with novel forms of catheter ablation.

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You’ve heard about outcome measures, so how do you use them? Integrating clinically relevant outcome measures in orthotic management of stroke

Prosthetics and Orthotics International ◽

10.1177/0309364612446650 ◽

2012 ◽

Vol 37 (1) ◽

pp. 30-42 ◽

Cited By ~ 4

Author(s):

Christopher Robinson ◽

Stefania Fatone

Keyword(s):

Clinical Practice ◽

Outcome Measures ◽

Careful Consideration ◽

International Classification Of Functioning ◽

Common Goal ◽

Disability And Health ◽

Healthcare Environment ◽

Relevant Outcome ◽

Selection Of

In today’s healthcare environment it is increasingly important to be able to quantify the amount of change associated with a given intervention; this can be accomplished using one or more appropriate outcome measures. However, the selection and integration of outcome measures within clinical practice requires careful consideration. This includes identification of the measure construct which can be assisted by the International Classification of Functioning, Disability, and Health; selection of outcome measures based on need, appropriateness and feasibility; and careful use in regular clinical practice including data collection, analysis and re-assessment of the process. We describe this process, focusing on orthotic management of stroke, in particular the improvement of mobility as a common goal. Clinical relevance The growing emphasis on improved documentation of patient care and outcomes requires that clinicians integrate clinically relevant outcome measures into their practice. We suggest a process to assist clinicians integrate outcome measures into clinical practice with a particular emphasis on the orthotic management of stroke.

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