Identifying and addressing barriers for insulin use in patients with type-2 diabetes mellitus

2018 ◽  
Vol 09 ◽  
Author(s):  
Ibrahim El Bayoumy
2021 ◽  
Vol 18 ◽  
Author(s):  
Elvan Wiyarta ◽  
Wismandari Wisnu

Background: Insulin has recently received special attention concerning its use in COVID-19 patients. Although controversial, insulin can be able to worsen the prognosis of COVID-19 patients with Type 2 Diabetes Mellitus (T2DM) through an inflammatory pathway. This uncertain aspect brings a new perspective related to insulin use in this pandemic era. Objective: We tried to collect and analyze various studies related to this issue to provide a complete picture of the prognosis of insulin use in COVID-19 patients with T2DM. Methods: We comprehensively searched PubMed, Cochrane CENTRAL, Embase, EBSCO CINAHL, MEDLINE, and grey literature databases for studies investigating the effect of insulin on COVID-19 outcomes, including mortality, hospitalization, disease progression, other prognostic surrogates. Records were screened against the eligibility criteria. Result: 2556 articles were retrieved and were screened. A total of 8 studies were included in the final analysis. There are no studies with solid evidence supporting the effect of insulin treatment on the worsening of the prognosis of COVID-19 patients with T2DM. Although several studies have shown that insulin is associated with a poor prognosis, most studies have not considered confounders. This certainly makes it challenging to analyze the effects of insulin independently. Conclusion: We propose that COVID-19 patients with T2DM continue to receive insulin, but with careful observation of the risk of disease progression.


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2004 ◽  
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pp. 81-85 ◽  
Author(s):  
Samy I McFarlane ◽  
Fadi El-Atat ◽  
Jonathan Castro ◽  
John Shin ◽  
Linda Joseph ◽  
...  

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pp. 2103-2110 ◽  
Author(s):  
Naushira Pandya ◽  
Wenhui Wei ◽  
Juliana L. Meyers ◽  
Brett S. Kilpatrick ◽  
Keith L. Davis

2013 ◽  
Vol 41 (5) ◽  
pp. 584-590 ◽  
Author(s):  
E. J. Barker ◽  
T. M. Valentijn ◽  
K. M. Van De Luijtgaarden ◽  
S. E. Hoeks ◽  
M. T. Voute ◽  
...  

2012 ◽  
Vol 132 (9) ◽  
pp. 2186-2191 ◽  
Author(s):  
Christina C. Newton ◽  
Susan M. Gapstur ◽  
Peter T. Campbell ◽  
Eric J. Jacobs

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