scholarly journals Clinical Application of Technetium-99m-Labeled Red Blood Cells Subcutaneous Radionuclide Venography and Abdominal/Pelvic Hybrid SPECT/CT Imaging in Patients with Suspicion of Proximal Deep Vein Thrombosis

2016 ◽  
Vol 7 (5) ◽  
Author(s):  
Liu CT ◽  
Chu HL ◽  
Tsai IH ◽  
Chang YL
Keyword(s):  
Deep Vein Thrombosis ◽  
Red Blood Cells ◽  
Clinical Application ◽  
Blood Cells ◽  
Ct Imaging ◽  
Proximal Deep Vein Thrombosis ◽  
Technetium 99M ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Radionuclide Venography

scholarly journals Influence of Prescribed Blood Products on the Incidence of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients

2017 ◽  
Vol 23 (8) ◽  
pp. 938-942
Author(s):  
Alenka Premuš Marušič ◽  
Igor Locatelli ◽  
Aleš Mrhar ◽  
Martin Caprnda ◽  
Ludovit Gaspar ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Surgical Patients ◽  
Blood Products ◽  
Control Groups ◽  
Packed Red Blood Cells ◽  
Vein Thrombosis ◽  
And Control ◽  
Deep Vein

Deep vein thrombosis (DVT) and pulmonary embolisms (PEs) are common complications after surgical procedures. The influence of prescribed blood products on the occurrence of DVT and PE was evaluated in postsurgical patients in this retrospective case–control study. The records of 286 surgical patients were analyzed: DVT (n = 52), PE (n = 92), and a control group (n = 142). The amounts of prescribed blood, blood products, and vitamin K were reviewed, together with appropriate prescribing of low-molecular-weight heparins. The influence of prescribed blood products on the occurrence of DVT or PE was analyzed using multinomial logistic regression. We demonstrated a significant difference between the test and control groups ( P < .05) in relation to receiving packed red blood cells. Treatment with red blood cells was associated with an increased risk of PE but not DVT. Patients who developed PE after surgery were hospitalized for longer (median 10 days) than patients with DVT (median 6 days). There was no difference between the test and control groups concerning treatment with fresh frozen plasma. Inadequate thromboprophylaxis significantly increased the likelihood of DVT. There is a connection between receiving packed red blood cells and occurrence of postoperative PE in surgical patients. Thus, patients receiving red blood cells should be monitored more closely after surgery, as they are more likely to develop PE postoperatively.

scholarly journals (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0261567
Author(s):  
Samuel A. Hendley ◽  
Aarushi Bhargava ◽  
Christy K. Holland ◽  
Geoffrey D. Wool ◽  
Osman Ahmed ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Thrombolytic Therapy ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Vein Thrombosis ◽  
Clinical Dose ◽  
Infusion Catheter ◽  
Catheter Directed Thrombolysis ◽  
The Common ◽  
Deep Vein

Deep vein thrombosis is a major source of morbidity and mortality worldwide. For acute proximal deep vein thrombosis, catheter-directed thrombolytic therapy is an accepted method for vessel recanalization. Thrombolytic therapy is not without risk, including the potential for hemorrhagic bleeding that increases with lytic dose. Histotripsy is a focused ultrasound therapy that generates bubble clouds spontaneously in tissue at depth. The mechanical activity of histotripsy increases the efficacy of thrombolytic therapy at doses consistent with current pharmacomechanical treatments for venous thrombosis. The objective of this study was to determine the influence of lytic dose on histotripsy-enhanced fibrinolysis. Human whole blood clots formed in vitro were exposed to histotripsy and a thrombolytic agent (recombinant tissue plasminogen activator, rt-PA) in a venous flow model perfused with plasma. Lytic was administered into the clot via an infusion catheter at concentrations ranging from 0 (control) to 4.54 μg/mL (a common clinical dose for catheter-directed thrombolysis). Following treatment, perfusate samples were assayed for markers of fibrinolysis, hemolysis, and intact red blood cells and platelets. Fibrinolysis was equivalent between the common clinical dose of rt-PA (4.54 μg/mL) and rt-PA at a reduction to one-twentieth of the common clinical dose (0.23 μg/mL) when combined with histotripsy. Minimal changes were observed in hemolysis for treatment arms with or without histotripsy, potentially due to clot damage from insertion of the infusion catheter. Likewise, histotripsy did not increase the concentration of red blood cells or platelets in the perfusate following treatment compared to rt-PA alone. At the highest lytic dose, a refined histotripsy exposure scheme was implemented to cover larger areas of the clot. The updated exposure scheme improved clot mass loss and fibrinolysis relative to administration of lytic alone. Overall, the data collected in this study indicate the rt-PA dose can be reduced by more than a factor of ten and still promote fibrinolysis when combined with histotripsy.

Role of radionuclide venography in the detection of proximal deep vein thrombosis

1993 ◽  
Vol 14 (11) ◽  
pp. 1014-1022???1022 ◽  
Author(s):  
M. Kh. MOHAMADIYEH ◽  
A. A. SHABAN ◽  
M. EL-DESOUKI ◽  
T. MALABAREY ◽  
P. J. ELL
Keyword(s):  
Deep Vein Thrombosis ◽  
Proximal Deep Vein Thrombosis ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Radionuclide Venography

99mTc labeled red blood cells versus ?-phlebography in diagnosis of deep vein thrombosis

1982 ◽  
Vol 7 (2) ◽  
Author(s):  
G. Jacolot ◽  
P. Legendre ◽  
L. Millour ◽  
J.F. Morin ◽  
P.P. Morin
Keyword(s):  
Deep Vein Thrombosis ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Marit Engeseth ◽  
Tone Enden ◽  
Per Morten Sandset ◽  
Hilde Skuterud Wik
Keyword(s):  
Deep Vein Thrombosis ◽  
Proximal Deep Vein Thrombosis ◽  
Cross Sectional ◽  
Clinical Criteria ◽  
Vein Thrombosis ◽  
Post Thrombotic Syndrome ◽  
Younger Age ◽  
Deep Vein

Abstract Background Post-thrombotic syndrome (PTS) is a frequent chronic complication of proximal deep vein thrombosis (DVT) of the lower limb, but predictors of PTS are not well established. We aimed to examine predictors of PTS in patients with long-term PTS following proximal DVT. Methods During 2006–09, 209 patients with a first time acute upper femoral or iliofemoral DVT were randomized to receive either additional catheter-directed thrombolysis or conventional therapy alone. In 2017, the 170 still-living participants were invited to participate in a cross-sectional follow-up study. In the absence of a gold standard diagnostic test, PTS was defined in line with clinical practice by four mandatory, predefined clinical criteria: 1. An objectively verified DVT; 2. Chronic complaints (> 1 month) in the DVT leg; 3. Complaints appeared after the DVT; and 4. An alternative diagnosis was unlikely. Possible predictors of PTS were identified with multivariate logistic regression. Results Eighty-eight patients (52%) were included 8–10 years following the index DVT, and 44 patients (50%) were diagnosed with PTS by the predefined clinical criteria. Younger age and higher baseline Villalta score were found to be independent predictors of PTS, i.e., OR 0.96 (95% CI, 0.93–0.99), and 1.23 (95% CI, 1.02–1.49), respectively. Lack of iliofemoral patency at six months follow-up was significant in the bivariate analysis, but did not prove to be significant after the multivariate adjustments. Conclusions In long-term follow up after high proximal DVT, younger age and higher Villalta score at DVT diagnosis were independent predictors of PTS.

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