scholarly journals Prevalence of Vitamin D Deficiency, Metabolic Syndrome and Association Between the Two in a South Asian Population

2018 ◽  
Vol 08 (02) ◽  
Author(s):  
Ramesh Reddy Allam ◽  
Rashmi Pant ◽  
Chengappa K Uthappa ◽  
Manjunath Dinaker ◽  
Ganesh Oruganti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
South Asian ◽  
Asian Population ◽  
South Asian Population

scholarly journals Prevalence of vitamin D deficiency and its association with diabetes in a South-Asian population

2015 ◽  
Author(s):  
Kavinga Gunawardane ◽  
Noel Somasundaram ◽  
Neil Thalagala ◽  
Pubudu Chulasiri ◽  
Sudath Fernando
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
South Asian ◽  
Asian Population ◽  
South Asian Population

scholarly journals High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Mahbubul H. Siddiqee ◽  
Badhan Bhattacharjee ◽  
Umme Ruman Siddiqi ◽  
Mohammad Meshbahur Rahman
Keyword(s):  
Vitamin D ◽  
South Asia ◽  
Vitamin D Deficiency ◽  
South Asian ◽  
Asian Population ◽  
Asian Countries ◽  
The South ◽  
South Asian Population ◽  
Pooled Prevalence ◽  
Meta Analyses

Abstract Background: Vitamin D deficiency is linked to a wide range of chronic and infectious diseases. Body of literature suggested that the prevalence of this deficiency can have geographical variation. Although, vitamin D deficiency is frequently reported in the South Asian population, the scarcity of systematic reviews and meta-analyses means the true extent of the disease and the underlying factors causing it are poorly characterized.Methods: A systematic search was performed using databases (PubMed, Scopus and Google Scholar) for original studies on the South Asian population (published from January 1, 2001 to December 31, 2019). Following the search, a random effect meta-analyses was performed to calculate population level weighted average, pooled prevalence of deficiency, and heterogeneity of vitamin D among different countries and genders; in addition to South Asia as a whole.Results: Our study, based on our selection criteria was narrowed down to a total of 44,717 participants; that spanned over 65 studies from five South Asian countries. Overall, the pooled prevalence of deficiency was 68% [95% CI: 64% to 72%] with significant heterogeneity (I2 = 98%; p = 0.00). Average level of vitamin D ranged from 4.7 to 32 ng/mL, with a weighted mean of 19.15 ng/mL (weighted standard deviation 11.59 ng/mL). The highest prevalence of vitamin D deficiency was found in Pakistan (73%; 95% CI: 63% to 83%) followed by Bangladesh (67%; 95% CI: 50% to 83%), India (67%; 95% CI: 61% to 73%), Nepal (57%; 95% CI: 53% to 60%) and Sri Lanka (48%; 95% CI: 41% to 55%), respectively. This finding indicated a high degree of heterogeneity among the population. (I2 = 98.76%), Furthermore, a gender wise analysis suggested that in South Asia, the prevalence of vitamin D deficiency was higher in females than males. Conclusion: Our findings reveal highly prevalent and variable vitamin D deficiency among the adults of different South Asian countries. Findings from this review would be helpful to generate hypotheses and explore the factors affecting the inter-country variability, alongside strengthening evidence for governments to prioritize mitigation strategies in this region.

scholarly journals High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mahbubul H. Siddiqee ◽  
Badhan Bhattacharjee ◽  
Umme Ruman Siddiqi ◽  
Mohammad MeshbahurRahman
Keyword(s):  
Vitamin D ◽  
South Asia ◽  
Vitamin D Deficiency ◽  
South Asian ◽  
Meta Analysis ◽  
Asian Population ◽  
Asian Countries ◽  
The South ◽  
South Asian Population ◽  
Pooled Prevalence

Abstract Background Vitamin-D deficiency is linked to a wide range of chronic and infectious diseases. Body of literature suggested that the prevalence of this deficiency can have geographical variation. Although vitamin D deficiency is frequently reported in the South Asian population, the scarcity of systematic reviews and meta-analysis means the true extent of the disease and the underlying factors causing it are poorly characterized. Methods A systematic search was performed using two databases (PubMed and Scopus) and one search engine (Google Scholar) for original studies on the South Asian population (published from January 1, 2001, to December 31, 2019). Following the search, a random effect meta-analysis was performed to calculate population-level weighted average, the pooled prevalence of deficiency, and heterogeneity of vitamin D among different countries and genders; in addition to South Asia as a whole. Results Our study, based on our selection criteria was narrowed down to a total of 44,717 participants; which spanned over 65 studies from five South Asian countries. Overall, the pooled prevalence of deficiency was 68% [95% CI: 64 to 72%] with significant heterogeneity (I2 = 98%; p = 0.00). The average level of vitamin D ranged from 4.7 to 32 ng/mL, with a weighted mean of 19.15 ng/mL (weighted standard deviation 11.59 ng/mL). The highest prevalence of vitamin D deficiency was found in Pakistan (73%;95% CI: 63 to 83%) followed by Bangladesh (67%; 95% CI: 50 to 83%), India (67%; 95% CI: 61 to 73%), Nepal (57%; 95% CI: 53 to 60%) and Sri Lanka (48%; 95% CI: 41 to 55%), respectively. This finding indicated a high degree of heterogeneity among the population. (I2 = 98.76%), Furthermore, a gender-wise analysis suggested that in South Asia, the prevalence of vitamin D deficiency was higher in females than males. Conclusion Our findings reveal highly prevalent and variable vitamin D deficiency among the adults of different South Asian countries. Findings from this review would be helpful to generate hypotheses and explore the factors affecting the inter-country variability, alongside strengthening evidence for governments to prioritize mitigation strategies in this region.

scholarly journals Early Life Determinants of Metabolic Syndrome and Diabetes Mellitus in South Asian Population Living in Europe: A Systematic Review

2013 ◽  
Vol 16 (7) ◽  
pp. A434-A435
Author(s):  
D. Callejo ◽  
H. Díaz-Cuervo ◽  
J. Cuervo ◽  
P. Rebollo ◽  
A. Hussain ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Metabolic Syndrome ◽  
South Asian ◽  
Early Life ◽  
Asian Population ◽  
South Asian Population

Vitamin D deficiency and risk of metabolic syndrome

2018 ◽  
Author(s):  
Alena Andreeva ◽  
Olga Belyaeva ◽  
Anna Bystrova ◽  
Elena Bajenova ◽  
Tatiana Karonova
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency

Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3

2020 ◽  
Vol 20 (8) ◽  
pp. 1282-1294
Author(s):  
Meroua Bouchemal ◽  
Djennat Hakem ◽  
Malha Azzouz ◽  
Chafia Touil-Boukoffa ◽  
Dalila Mezioug
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Active Metabolite ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
No Production ◽  
Immunomodulatory Effects ◽  
Immune Balance ◽  
Vitamin D Levels

Background: Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It is associated with the presence of various inflammatory molecules. Vitamin D plays an important role in the regulation of metabolism homeostasis. Objective: The main goal of this work is to investigate vitamin D levels among Algerian MetS patients and its possible outcomes on key molecules of the immune response, as well, the immunomodulatory effects of its active metabolite. Methods: We evaluated vitamin D status by the electrochemiluminescence method, Nitric Oxide (NO) levels by the Griess method and Matrix Metalloproteinases (MMPs) activities such as MMP-2 and MMP-9 by zymography in plasma of patients and healthy controls (HC). The immunomodulatory effects of the active metabolite of vitamin D (α-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF- β and s-CTLA-4 were assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. MMPs activities were also determined ex-vivo, while iNOS expression was assessed by immunofluorescence staining. Results: Severe vitamin D deficiency was registered in Algerian MetS patients. The deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity. Interestingly, α-25 (OH)2D3 declined the NO/iNOS system and IL-6 production, as well as MMPs activities. However, the ex-vivo production of IL-10, TGF-β increased in response to the treatment. We observed in the same way, the implication of s-CTLA-4 in MetS, which was markedly up-regulated with α-25 (OH)2D3. Conclusion: Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance.

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

Sign in / Sign up

Export Citation Format

Share Document