Mean platelet volume measurements affecting evaluation of parameters in dialysis patients (The affective of mean platelet volume)

Abstract Background and Aims Higher Mean Platelet Volume (MPV), as an indicator of larger and hyper-reactive platelets and low serum Mg levels (sMg) have emerged as cardiovascular risk markers, in the general and dialysis population. Magnesium deficiency is linked to platelet hyper-reactivity. Since HypoMagnesemia is common and associated to increased mortality among Peritoneal Dialysis (PD) patients, we aimed to investigate the association of sMg with MVP in PD patients. Method We studied 95 stable PD patients, 51 men 44 women, with a mean age of 63 ±14 years. Data analyzed included patients demographics, clinical and biochemical data. Univariate and multivariate regression analysis were used to test the associations of variables related to MPV. Results: . The mean platelet (PLT) volume was 9.4 ±1.5 (median: 9.2) fl. The mean platelet (PLT) count was 235 ± 69 (median: 233) [x103μ/L]. The mean sMg was 2.25 ± 0.47 (median: 2.2) mg/dl. MPV was associated positively (p=0.303; p<0.01) with C-reactive protein (CRP) and negatively with sMg (r= -0.246; p<0.05), use of Renin Angiotensin System (RAS) Inhibitors (r=-0.273; p<0.05), PLT count (r=-0.360; p<0.001) and white blood cell (WBC) count (r=-0.254; p<0.05). The results of our multiple regression model (Table) showed that all the above mentioned factors that were included in the model, except WBC, were independent determinants of MPV. Conclusion Our results show a significant inverse correlation of serum Magnesium with Mean Platelet Volume in Peritoneal Dialysis patients. Given the emerging role of Mg in platelet reactivity, sustaining higher sMg levels, along with minimizing inflammation and using RAS inhibitors may improve cardiovascular outcomes in PD patients via modulation of MPV.

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Comorbidities must Be Considered in Mean Platelet Volume Measurements in Patients with Adnexial Torsion

Balkan Medical Journal ◽

10.5152/balkanmedj.2016.16107 ◽

2016 ◽

Vol 33 (4) ◽

pp. 482-482

Author(s):

Ercan Varol

Keyword(s):

Mean Platelet Volume ◽

Platelet Volume ◽

Volume Measurements

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Mean platelet volume measurements should not be used as an indicator of platelet function

Acta Cardiologica ◽

10.1080/00015385.2017.1346451 ◽

2017 ◽

Vol 73 (1) ◽

pp. 107-107

Author(s):

Cengiz Beyan ◽

Esin Beyan

Keyword(s):

Platelet Function ◽

Mean Platelet Volume ◽

Platelet Volume ◽

Volume Measurements

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Klinische und labordiagnostische Parameter bei 21 Hunden mit primärer immunvermittelter Thrombozytopenie

Tierärztliche Praxis Ausgabe K Kleintiere / Heimtiere ◽

10.1055/s-0037-1622569 ◽

2011 ◽

Vol 39 (01) ◽

pp. 17-24 ◽

Cited By ~ 1

Author(s):

H. J. Schuberth ◽

R. Mischke ◽

B. Dircks

Keyword(s):

Mean Platelet Volume ◽

Platelet Volume ◽

Klinische Relevanz

Zusammenfassung Gegenstand und Ziel: Charakterisierung von klinischen und labordiagnostischen Parametern sowie Therapie und Krankheitsverlauf bei Hunden mit einer angenommenen primären immunvermittelten Thrombozytopenie (pIMT) und Identifizierung möglicher Besonderheiten im Vergleich zu Hunden mit einer sekundären immunvermittelten Thrombozytopenie (sIMT). Material und Methoden: Retrospektive Auswertung von Patientendaten thrombozytopenischer Hunde, bei denen plättchengebundene Antikörper mittels Durchflusszytometrie nachgewiesen wurden. Ergebnisse: Dreizehn der 21 Hunde (62%) mit einer pIMT waren männlich. Das mittlere Alter bei Erstvorstellung betrug 6,6 Jahre (1,6–13,5 Jahre [Median; Minimum–Maximum]). Blutungen, hauptsächlich in Form von Haut- und Schleimhautblutungen, lagen bei 18 Hunden (86%) vor. Neunzehn Hunde (91%) wiesen eine Thrombozytenzahl unter 20000/μl auf. Bei allen Hunden mit einer pIMT ergab sich ein mittleres Thrombozytenvolumen (mean platelet volume, MPV) im oder unter dem Referenzbereich. In nahezu allen Fällen bestand eine gesteigerte Megakaryopoeseaktivität. Der Vergleich zweier Therapieregime (Prednisolon versus Prednisolon und Azathioprin) zeigte keinen signifikanten Unterschied bezüglich der Zeit bis zum Erreichen einer Thrombozytenzahl im Referenzbereich. Zwischen Patienten mit pIMT oder sIMT ließ sich im Hinblick auf Alter und Geschlecht kein signifikanter Unterschied feststellen. Bei Hunden mit einer pIMT waren Thrombozytenzahl und MPV signifikant niedriger und die Megakaryopoeseaktivität signifikant häufiger erhöht. Schlussfolgerung und klinische Relevanz: Bei Hunden, die plättchengebundene Antikörper und zusätzlich eine schwere Thrombozytopenie, ein niedriges MPV und eine gesteigerte Megakaryopoeseaktivität aufweisen, ist eine pIMT naheliegend.

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Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651061 ◽

1987 ◽

Vol 57 (01) ◽

pp. 55-58 ◽

Cited By ~ 37

Author(s):

J F Martin ◽

T D Daniel ◽

E A Trowbridge

Keyword(s):

Platelet Count ◽

Mean Platelet Volume ◽

Artery Bypass ◽

Bypass Graft ◽

Control Group ◽

Artery Bypass Graft ◽

Platelet Volume ◽

Young Males ◽

The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

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