Numerical Study on the Dynamics and Oxygen Uptake of Healthy and Malaria-Infected Red Blood Cells

2015 ◽  
Vol 7 (5) ◽  
pp. 549-568
Author(s):  
P. G. Jayathilake ◽  
Gang Liu ◽  
Zhijun Tan ◽  
B. C. Khoo
Keyword(s):  
Oxygen Uptake ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Numerical Study ◽  
Numerical Technique ◽  
Separation Distance ◽  
Immersed Interface Method ◽  
Immersed Interface ◽  
Pulmonary Capillaries

AbstractRed blood cells (RBCs) are very important due to their role of oxygen transport from lungs. As the malaria parasite grows in the malaria-infected red blood cells (IRBCs), the properties of the cells change. In the present work, the oxygen uptake by RBCs and IRBCs at the pulmonary capillaries is simulated using a numerical technique based on the two-dimensional immersed interface method. The results for the oxygen uptake by a stationary single RBC have fair agreements with the previously reported results. The numerical results show that the malaria infection could significantly cause deterioration on the oxygen uptake by red blood cells. The results also suggest that the oxygen uptake by individual stationary RBC/IRBC would not be significantly affected by the neighboring cells provided the separation distance is about the dimension of the cell. Furthermore, it appears that the oxygen uptake by both RBCs and IRBCs is dominated by mass diffusion over the convection although the Peclet number is of the order of unity.

Some factors affecting oxygen uptake by red blood cells in the pulmonary capillaries

2001 ◽  
Vol 169 (2) ◽  
pp. 153-172 ◽  
Author(s):  
Jonathan P. Whiteley ◽  
David J. Gavaghan ◽  
Clive E.W. Hahn
Keyword(s):  
Oxygen Uptake ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Factors Affecting ◽  
Pulmonary Capillaries

Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell Disease

Hematology ◽  
2007 ◽  
Vol 2007 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Marilyn J. Telen
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Adhesion Molecules ◽  
Sickle Cell ◽  
Vascular Endothelium ◽  
Blood Cells ◽  
Cell Disease ◽  
Adhesive Interactions ◽  
Lines Of Evidence

AbstractA number of lines of evidence now support the hypothesis that vaso-occlusion and several of the sequelae of sickle cell disease (SCD) arise, at least in part, from adhesive interactions of sickle red blood cells, leukocytes, and the endothelium. Both experimental and genetic evidence provide support for the importance of these interactions. It is likely that future therapies for SCD might target one or more of these interactions.

scholarly journals Role of Calcium in Phosphatidylserine Externalisation in Red Blood Cells from Sickle Cell Patients

Anemia ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Erwin Weiss ◽  
David Charles Rees ◽  
John Stanley Gibson
Keyword(s):  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Phosphatidylserine Exposure ◽  
Channel Inhibition ◽  
Cation Conductance ◽  
Gardos Channel ◽  
Cation Permeability

Phosphatidylserine exposure occurs in red blood cells (RBCs) from sickle cell disease (SCD) patients and is increased by deoxygenation. The mechanisms responsible remain unclear. RBCs from SCD patients also have elevated cation permeability, and, in particular, a deoxygenation-induced cation conductance which mediates entry, providing an obvious link with phosphatidylserine exposure. The role of was investigated using FITC-labelled annexin. Results confirmed high phosphatidylserine exposure in RBCs from SCD patients increasing upon deoxygenation. When deoxygenated, phosphatidylserine exposure was further elevated as extracellular [] was increased. This effect was inhibited by dipyridamole, intracellular chelation, and Gardos channel inhibition. Phosphatidylserine exposure was reduced in high saline. levels required to elicit phosphatidylserine exposure were in the low micromolar range. Findings are consistent with entry through the deoxygenation-induced pathway (), activating the Gardos channel. [] required for phosphatidylserine scrambling are in the range achievablein vivo.

scholarly journals ANALYSIS OF OPTICAL WAVEGUIDES WITH ARBITRARY INDEX PROFILE USING AN IMMERSED INTERFACE METHOD

2011 ◽  
Vol 22 (07) ◽  
pp. 687-710 ◽  
Author(s):  
THEODOROS P. HORIKIS
Keyword(s):  
Optical Waveguides ◽  
Eigenvalue Problems ◽  
Numerical Technique ◽  
Interface Problems ◽  
Index Profile ◽  
Immersed Interface Method ◽  
Immersed Interface ◽  
Light Confinement ◽  
Bragg Fibers ◽  
Matrix Eigenvalue Problems

A numerical technique is described that can efficiently compute solutions of interface problems. These are problems with data, such as the coefficients of differential equations, discontinuous or even singular across one or more interfaces. A prime example of these problems are optical waveguides, and as such the scheme is applied to Maxwell's equations as they are formulated to describe light confinement in Bragg fibers. It is based on standard finite differences appropriately modified to take into account all possible discontinuities across the waveguide's interfaces due to the change of the refractive index. Second- and fourth-order schemes are described with additional adaptations to handle matrix eigenvalue problems, demanding geometries and defects.

The role of red blood cells in the progression and instability of atherosclerotic plaque

2010 ◽  
Vol 142 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Dimitrios N. Tziakas ◽  
Georgios K. Chalikias ◽  
Dimitrios Stakos ◽  
Harisios Boudoulas
Keyword(s):  
Red Blood Cells ◽  
Atherosclerotic Plaque ◽  
Blood Cells

Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin

1978 ◽  
Vol 45 (1) ◽  
pp. 7-10 ◽  
Author(s):  
H. Bard ◽  
J. C. Fouron ◽  
J. E. Robillard ◽  
A. Cornet ◽  
M. A. Soukini
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Oxygen Affinity ◽  
Fetal Life ◽  
Red Cell ◽  
Adult Type ◽  
Fetal Sheep ◽  
Adult Hemoglobin ◽  
Relationship Of

Studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (DPG), the intracellular red cell and extracellular pH, and the switchover to adult hemoglobin synthesis in regulating the position of the fetal red cell oxygen-affinity curve in utero. Adult hemoglobin first appeared near 120 days of gestation. The mean oxygen tension at which hemoglobin is half saturated (P50) prior to 120 days of gestation remained constant at 13.9 +/- 0.3 (SD) Torr and then increased gradually as gestation continued, reaching 19 Torr at term. During the interval of fetal life studied, the level of DPG was 4.43 +/- 1.63 (SD) micromol/g Hb and the deltapH between plasma and red blood cells was 0.227 +/- 0.038 (SD); neither was affected by gestational age. The decrease in the red cell oxygen affinity after 120 days of gestation ocrrelated with the amount of adult hemoglobin present in the fetus (r = 0.78; P less than 0.001). This decrease can be attributed only to the amount of the adult-type hemoglobin present, and not to DPG, or to changes in the deltapH between plasma and red blood cells, because both remained stable during the last trimester.

Blocked Lipid Exchange in Bilayers and its Possible Influence on the Shape of Vesicles

1974 ◽  
Vol 29 (9-10) ◽  
pp. 510-515 ◽  
Author(s):  
W Helfrich
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Spontaneous Curvature ◽  
Lipid Exchange ◽  
Lipid Distribution ◽  
Shape Transformations ◽  
Curvature Elasticity ◽  
Possible Cause

Abstract The role of lipid exchange in the curvature elasticity of bilayers is studied theoretically. Blocking of exchange between the monolayers may give rise to a nonequilibrium lipid distribution going hand in hand with a spontaneous curvature. Some possible consequences for vesicular deformations are discussed. Lipid nonequilibrium is tentatively suggest as one possible cause for certain shape transformations of red blood cells

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