Syntheses of Coordination Compounds of 2-Amino-3-Methylbutanoic Acid Their Mixed Ligand Complexes and Antibacterial Activities

Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.

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Syntheses, Characterization and Biological Activity of Coordination Compounds of Propanedioic Acid and its Mixed Ligand Complexes with N,N'-Dihydroxy-2,3-butanediimine

Asian Journal of Chemistry ◽

10.14233/ajchem.2021.23309 ◽

2021 ◽

Vol 33 (8) ◽

pp. 1911-1918

Author(s):

T.O. Aiyelabola ◽

E.O. Akinkunmi ◽

O Osungunna

Keyword(s):

Antimicrobial Activity ◽

Metal Ions ◽

Coordination Compounds ◽

Mixed Ligand Complex ◽

Octahedral Geometry ◽

Mixed Ligand ◽

Mixed Ligand Complexes ◽

Planar Geometry ◽

Acid Complex ◽

Square Planar

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

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Synthesis, Characterization and Antibacterial Activities of Mixed Ligand Complexes of Schiff Base Derived from Benzidine and 2-Benzoyl benzoic acid

Diyala Journal for Pure Science ◽

10.24237/djps.1303.189c ◽

2017 ◽

Vol 13 (3) ◽

pp. 21-37

Author(s):

Rehab K. Al- shemary ◽

◽

Basima Abdul HussinZaidan ◽

Nibras A. Al-marsomy

Keyword(s):

Schiff Base ◽

Benzoic Acid ◽

Antibacterial Activities ◽

Mixed Ligand ◽

Mixed Ligand Complexes

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CONFIGURATION AND COMPETITIVE REACTIVITY OF LIGANDS IN MIXED LIGAND COMPLEXES OF DIALKYLDITIOPHOSPHATES AND AMINOBENBENZIMIDAZOLE (Part I: Au, Pt, Ag) AMINOBENBENZIMIDAZOLE (Part 2. Zn, Fe, Ni)

CHEMISTRY AND CHEMICAL ENGINEERING ◽

10.51348/vfck9268 ◽

2020 ◽

pp. 7-16

Keyword(s):

Coordination Compounds ◽

Mixed Ligand ◽

Mixed Ligand Complexes ◽

Chelating Ligands ◽

Frontier Orbitals ◽

Chemical Methods ◽

Geometrical Structures ◽

Software Packages ◽

Quantum Chemical Methods

With the aim of determination of electronic and geometrical structures of mixed-ligand complexes, theoretical modeling of the structures of coordination compounds of transition metals with dialkyldithiophosphate chelating ligands with aminobenzimidazoles carried out using quantum chemical methods. Using BIOVIA Materials Accelrys Studio 2017 software packages, the geometry, electron density distribution, and frontier orbitals calculated for the mixed ligand complexes of Au(III), Pt(II), Ag(I), Cu(II), Ni(II), Fe(III), which are necessary for understanding the electronic structure of coordination compounds with chelating ligands.

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Mono-and Binuclear Cobalt(II) Mixed Ligand Complexes of 2,2’-Bipyridine and Ethylenediamine: Synthesis, Characterization and Biological Application

Biointerface Research in Applied Chemistry ◽

10.33263/briac122.19621973 ◽

2021 ◽

Vol 12 (2) ◽

pp. 1962-1973

Keyword(s):

Antibacterial Activities ◽

Spectroscopic Technique ◽

Mixed Ligand ◽

Mixed Ligand Complexes ◽

Diffusion Method ◽

E Coli ◽

Precursor Complex ◽

Chloride Determination ◽

Ft Ir ◽

Physicochemical Methods

Antibiotic resistance of pathogens to the current commercially available drugs is a serious problem. To curve this problem, the discovery of active compounds with a new mode of action is insistent. In line with this, we report two new complexes; mononuclear [Co(L1)2(L2)(H2O)]Cl2 and binuclear [Co2(L1)4(L2)(H2O)2]Cl4 using precursor complex, [Co(L1)2(H2O)2]Cl2, synthesized before; where L1: 2,2’-bipyridine and L2: ethylenediamine. The precursor complex was prepared from CoCl2.6H2O and L1 in ethanol, treated with a different mole of L2 under optimized reaction conditions to give the corresponding mono-and binuclear cobalt(II) mixed ligand complexes. These complexes were characterized using the spectroscopic technique (ICP-OES, UV-Vis, FT-IR) and physicochemical methods (chloride determination, thermal analysis, and conductance measurement). Their antibacterial activities were also tested against two Gram-negative (Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae)) and two Gram-positive (Staphylococcus aureus (S. aureus), Streptococcus pyogenes (S. pyogenes)) bacteria using the disc diffusion method. The new complexes showed better activities against K. pneumoniae than the reference Gentamycin. Furthermore, [Co(L1)2(L2)(H2O)]Cl2 demonstrated better activity than Gentamycin against S. aureus and E. coli.

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CONFIGURATION AND COMPETITIVE REACTIVITY OF LIGANDS IN MIXED LIGAND COMPLEXES OF DIALKYLDITIOPHOSPHATES AND AMINOBENBENZIMIDAZOLE (Part 2. Zn, Fe, Ni)

CHEMISTRY AND CHEMICAL ENGINEERING ◽

10.51348/ftdp6140 ◽

2020 ◽

Vol 2020 (3) ◽

pp. 12-19

Keyword(s):

Coordination Compounds ◽

Mixed Ligand ◽

Mixed Ligand Complexes ◽

Chelating Ligands ◽

Frontier Orbitals ◽

Chemical Methods ◽

Geometrical Structures ◽

Software Packages ◽

Quantum Chemical Methods

With the aim of determination of electronic and geometrical structures of mixed-ligand complexes, theoretical modeling of the structures of coordination compounds of transition metals with dialkyldithiophosphate chelating ligands with aminobenzimidazoles carried out using quantum chemical methods. Using BIOVIA Materials Accelrys Studio 2017 software packages, the geometry, electron density distribution, and frontier orbitals calculated for the mixed ligand complexes Zn(II), Cu(II), Ni(II), Fe(III), which is necessary for understanding the electronic structure of coordination compounds with chelating ligands.

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