scholarly journals Effect of Chronic Administration of Cadmium on Anxiety-Like, Depression-Like and Memory Deficits in Male and Female Rats: Possible Involvement of Oxidative Stress Mechanism

2018 ◽  
Vol 08 (05) ◽  
pp. 240-268 ◽  
Author(s):  
Mouloud Lamtai ◽  
Jihane Chaibat ◽  
Sihame Ouakki ◽  
Inssaf Berkiks ◽  
El-Housseine Rifi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Administration ◽  
Memory Deficits ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway

2018 ◽  
Vol 8 (8) ◽  
pp. 141 ◽  
Author(s):  
Mouloud Lamtai ◽  
Jihane Chaibat ◽  
Sihame Ouakki ◽  
Oussama Zghari ◽  
Abdelhalem Mesfioui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Chronic Administration ◽  
Female Rats ◽  
Spatial Learning And Memory ◽  
Cognitive Behavior ◽  
Male And Female ◽  
Male And Female Rats

Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken to examine whether Ni chronic administration can induce alterations of affective and cognitive behavior and oxidative stress in male and female rats. Twenty-four rats, for each gender, divided into control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or NiCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Morris Water Maze was used to evaluate the spatial learning and memory. The hippocampus of each animal was taken for biochemical examination. The results showed that Ni administration dose dependently increased anxiety-like behavior in both tests. A significant increase in depression-like symptoms was also exhibited by Ni treated rats. In the Morris Water Maze test, the spatial learning and memory were significantly impaired just in males treated with 1 mg/kg of Ni. With regard to biochemical analysis, activity of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased, while the levels of nitric oxide (NO) and lipid peroxidation (LPO) in the hippocampus were significantly increased in the Ni-treated groups. Consequently, chronic Ni administration induced behavioral and biochemical dysfunctions.

Cholestasis-associated reproductive toxicity in male and female rats: The fundamental role of mitochondrial impairment and oxidative stress

2019 ◽  
Vol 316 ◽  
pp. 60-72 ◽  
Author(s):  
Mohammad Mehdi Ommati ◽  
Omid Farshad ◽  
Hossein Niknahad ◽  
Mohammad Reza Arabnezhad ◽  
Negar Azarpira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive Toxicity ◽  
Female Rats ◽  
Male And Female ◽  
Mitochondrial Impairment ◽  
Male And Female Rats ◽  
And Oxidative Stress

scholarly journals Gender differences in biochemical markers and oxidative stress of rats after 28 days oral exposure to a mixture used for weight loss containing p-synephrine, ephedrine, salicin, and caffeine

2016 ◽  
Vol 52 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Gabriela Cristina Schmitt ◽  
Marcelo Dutra Arbo ◽  
Andréia Louise Lorensi ◽  
Ana Laura Bemvenuti Jacques ◽  
Sabrina Nunes do Nascimento ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Weight Loss ◽  
Clinical Signs ◽  
Female Rats ◽  
Male Rats ◽  
Oral Exposure ◽  
Toxicity Profile ◽  
Male And Female ◽  
Male And Female Rats ◽  
And Oxidative Stress

ABSTRACT The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ephedrine, salicin, and caffeine mixture (10:4:6:80 w/w respectively) in male and female Wistar rats. Body weight and signs of toxicity, morbidity, and mortality were observed daily. After 28 days, animals were euthanized and blood collected for hematological, biochemical, and oxidative stress evaluation. No clinical signs of toxicity, significant weight loss or deaths occurred, nor were there any significant alterations in hematological parameters. Biochemical and oxidative stress biomarkers showed lipid peroxidation, and hepatic and renal damage (p < 0.05; ANOVA/Bonferroni) in male rats (100 and 150 mg/kg) and a reduction (p < 0.05; ANOVA/Bonferroni) in glutathione (GSH) levels in all male groups. Female groups displayed no indications of oxidative stress or biochemical alterations. The different toxicity profile displayed by male and female rats suggests a hormonal influence on mixture effects. Results demonstrated that the tested mixture can alter oxidative status and promote renal and hepatic damages.

scholarly journals Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats

2020 ◽  
Vol 36 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Mouloud Lamtai ◽  
Oussama Zghari ◽  
Sihame Ouakki ◽  
Ilias Marmouzi ◽  
Abdelhalem Mesfioui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Female Rats ◽  
Copper Exposure ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Physiological characteristics associated with increased resistance to decompression sickness in male and female rats

2020 ◽  
Vol 129 (3) ◽  
pp. 612-625
Author(s):  
Jacky Lautridou ◽  
Emmanuel Dugrenot ◽  
Aline Amérand ◽  
Anthony Guernec ◽  
Karine Pichavant-Rafini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Selective Breeding ◽  
Decompression Sickness ◽  
Female Rats ◽  
Physiological Changes ◽  
Male And Female ◽  
Male And Female Rats ◽  
Leukocyte Counts ◽  
Components Analysis

By selective breeding of individuals resistant to decompression sickness (DCS) we previously obtained a rat model of inherited resistance to this pathology. Comparison of these individuals with nonresistant animals revealed differences in leukocyte counts, coagulation, and mitochondrial and vascular functions, but not resistance to oxidative stress. This study also reveals sex-related differences in the physiological changes associated with DCS resistance. A principal components analysis of our data allowed us to discriminate DCS-resistant males from standard ones, but not females. These differences represent possible mechanisms driving resistance to DCS. Although still far from the diver, this opens a pathway to future adaptation of personalized decompression procedures for “DCS-prone” individuals.

Hemodynamic and oxidative stress effects of gamma-radiation in both male and female rats

2016 ◽  
Vol 18 (3) ◽  
pp. 9-18
Author(s):  
Ismail M. Maulood ◽  
◽  
Ali H. Ahmed ◽  
Hawzeen K. Othman ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Female Rats ◽  
Male And Female ◽  
Stress Effects ◽  
Male And Female Rats ◽  
And Oxidative Stress
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