This chapter examines the constraints coming from the symmetry properties of the fundamental interactions on the possible values of the masses of elementary particles. We first establish a relation between the
range of an interaction and the mass of the particle which mediates it. This relation implies, in particular, that long-range interactions are mediated by massless particles. Then we argue that gauge invariant interactions are long ranged and, therefore, the associated gauge particles must have zero mass. Second, we look at the properties of the constituents of matter, the quarks and the leptons. We introduce the notion of chirality and we show that the known properties of weak interactions, combined with the requirement of gauge invariance, force these particles also to be massless. The conclusion is that gauge symmetries appear to be incompatible with massive elementary particles, in obvious contradiction with experiment. This is the problem of mass.