scholarly journals Endometrial Preparation for Frozen Embryo Transfer by Supplemented Natural Cycle versus Hormone Replacement Cycle in Regularly Cycling Women

2019 ◽  
Vol 09 (06) ◽  
pp. 827-837
Author(s):  
Suzan Samir Elsharkawy ◽  
Tamer Hanafy Mahmoud ◽  
Mervat Sheikh-Elarab Elsedeek ◽  
Eman Monier Abd Elkader Amer
Keyword(s):  
Embryo Transfer ◽  
Hormone Replacement ◽  
Frozen Embryo Transfer ◽  
Natural Cycle ◽  
Endometrial Preparation ◽  
Hormone Replacement Cycle ◽  
Replacement Cycle

scholarly journals Association between clinical and IVF laboratory parameters and miscarriage after single euploid embryo transfers

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
María del Carmen Nogales ◽  
María Cruz ◽  
Silvia de Frutos ◽  
Eva María Martínez ◽  
María Gaytán ◽  
...  
Keyword(s):  
Endometrial Thickness ◽  
Hormone Replacement ◽  
Natural Cycle ◽  
Obese Women ◽  
Male Factor ◽  
Endometrial Preparation ◽  
Hormone Replacement Cycle ◽  
Euploid Embryo ◽  
Replacement Cycle

Abstract Background The goal of this study was to investigate which factors, excluding embryo aneuploidies, are associated with miscarriage in patients who have undergone a single euploid blastocyst transfer. Methods Retrospective, observational and multicenter study with 2832 patients undergoing preimplantational genetic testing for aneuploidies (PGT-A) due to repeated implantation failure, recurrent pregnancy loss, advanced maternal age or severe male factor were transferred one single euploid embryo. Results One of the main findings was a significant relationship between body mass index (BMI) and miscarriage rates (13.4% in underweight women, 12.1% in normal weight, 14.5% in overweight, and 19.2% in obese women, odds ratio [OD] 1.04; 95% confidence interval [CI], 1.01–1.07 p = 0.006). Endometrial thickness (OD 0.65; 95%, 0.52–0.77 p = 0.04) and type of endometrial preparation (natural cycle or hormone replacement cycle) (OD 0.77; 95%, 0.52–0.77, p = 0.04) were also associated with miscarriage rates. Conclusions BMI was strongly associated to miscarriage rates. We also observed a weaker association with endometrial thickness and with the type of endometrial preparation (natural cycle or hormone replacement cycle). None of the other studied variables (biopsy day, maternal and male age, duration of infertility, cycle length, previous miscarriages, previous live births, previous In Vitro Fertilization (IVF) cycles, endometrial pattern and/or diagnosis) were associated with miscarriage rates.

scholarly journals Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seung Chik Jwa ◽  
Masashi Takamura ◽  
Akira Kuwahara ◽  
Takeshi Kajihara ◽  
Osamu Ishihara
Keyword(s):  
Ectopic Pregnancy ◽  
Embryo Transfer ◽  
Hormone Replacement ◽  
Total Sample ◽  
Frozen Embryo Transfer ◽  
Early Cleavage ◽  
Endometrial Preparation ◽  
Increased Risk ◽  
Similar Risk ◽  
Natural Cycles

AbstractStudies have consistently reported a significantly reduced incidence of ectopic pregnancy (EP) for frozen-thawed embryo transfer (ET) cycles compared with fresh cycles. However, only a few studies reported an association between endometrial preparation protocols on EP and results were conflicting. A registry-based retrospective cohort study of 153,354 clinical pregnancies following frozen single ETs between 2014 and 2017 were conducted, of which 792 cases of EP (0.52%) were reported. Blastocyst embryo transfers accounted for 87% of the total sample and were significantly associated with a decreased risk for EP compared with early cleavage ET (0.90% vs. 0.46%, adjusted OR = 0.50, 95% CI, 0.41 to 0.60). Compared with natural cycles, hormone replacement cycles (HRC) demonstrated a similar risk for EP (0.53% vs. 0.47%, adjusted OR = 1.12, 95% CI, 0.89 to 1.42). Subgroup analysis with or without tubal factor infertility and early cleavage/blastocyst ETs demonstrated similar non-significant associations. Endometrial preparation protocols using clomiphene (CC) were associated with a significantly increased risk for EP (1.12%, adjusted OR = 2.34; 95% CI, 1.38 to 3.98). These findings suggest that HRC and natural cycles had a similar risk for EP. Endometrial preparation using CC was associated with an increased risk of EP in frozen embryo transfer cycles.

scholarly journals Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Sezcan Mumusoglu ◽  
Mehtap Polat ◽  
Irem Yarali Ozbek ◽  
Gurkan Bozdag ◽  
Evangelos G. Papanikolaou ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Hormone Replacement ◽  
Treatment Protocol ◽  
Frozen Embryo Transfer ◽  
Blastocyst Transfer ◽  
Natural Cycle ◽  
Serum Progesterone ◽  
Replacement Treatment ◽  
Near Future ◽  
Natural Cycles

Despite the worldwide increase in frozen embryo transfer, the search for the best protocol to prime endometrium continues. Well-designed trials comparing various frozen embryo transfer protocols in terms of live birth rates, maternal, obstetric and neonatal outcome are urgently required. Currently, low-quality evidence indicates that, natural cycle, either true natural cycle or modified natural cycle, is superior to hormone replacement treatment protocol. Regarding warmed blastocyst transfer and frozen embryo transfer timing, the evidence suggests the 6th day of progesterone start, LH surge+6 day and hCG+7 day in hormone replacement treatment, true natural cycle and modified natural cycle protocols, respectively. Time corrections, due to inter-personal differences in the window of implantation or day of vitrification (day 5 or 6), should be explored further. Recently available evidence clearly indicates that, in hormone replacement treatment and natural cycles, there might be marked inter-personal variation in serum progesterone levels with an impact on reproductive outcomes, despite the use of the same dose and route of progesterone administration. The place of progesterone rescue protocols in patients with low serum progesterone levels one day prior to warmed blastocyst transfer in hormone replacement treatment and natural cycles is likely to be intensively explored in near future.

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