scholarly journals Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects

2014 ◽  
Vol 13 (3) ◽  
pp. 5143-5153 ◽  
Author(s):  
D.M. Miao ◽  
L.P. Zhang ◽  
H.P. Yu ◽  
J.Y. Zhang ◽  
W.K. Xiao ◽  
...  
Keyword(s):  
Ventricular Remodeling ◽  
Troponin T ◽  
Left Ventricular Remodeling ◽  
High Sensitivity ◽  
Serum Levels ◽  
Left Ventricular ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T ◽  
And Performance

Serum Levels of High-Sensitivity Troponin T: A Novel Marker for Cardiac Remodeling in Hypertrophic Cardiomyopathy

2010 ◽  
Vol 16 (12) ◽  
pp. 950-956 ◽  
Author(s):  
Victoria Moreno ◽  
Diana Hernández-Romero ◽  
Juan Antonio Vilchez ◽  
Antonio García-Honrubia ◽  
Francisco Cambronero ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Remodeling ◽  
Troponin T ◽  
High Sensitivity ◽  
Serum Levels ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T

scholarly journals Elevated high-sensitivity troponin T levels at 1-year follow-up are associated with increased long-term mortality after TAVR

2020 ◽  
Author(s):  
Hatim Seoudy ◽  
Moritz Lambers ◽  
Vincent Winkler ◽  
Linnea Dudlik ◽  
Sandra Freitag-Wolf ◽  
...  
Keyword(s):  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Adverse Outcomes ◽  
Chronic Obstructive ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T ◽  
Long Term Mortality

Abstract Background Elevated pre-procedural high-sensitivity troponin T (hs-TnT) levels predict adverse outcomes in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). It is unknown whether elevated troponin levels still provide prognostic information during follow-up after successful TAVR. We evaluated the long-term implications of elevated hs-TnT levels found at 1-year post-TAVR. Methods and results The study included 349 patients who underwent TAVR for severe AS from 2010–2019 and for whom 1-year hs-TnT levels were available. Any required percutaneous coronary interventions were performed > 1 week before TAVR. The primary endpoint was survival time starting at 1-year post-TAVR. Optimal hs-TnT cutoff for stratifying risk, identified by ROC analysis, was 39.4 pg/mL. 292 patients had hs-TnT < 39.4 pg/mL (median 18.3 pg/mL) and 57 had hs-TnT ≥ 39.4 pg/mL (median 51.2 pg/mL). The high hs-TnT group had a higher median N-terminal pro-B-type natriuretic peptide (NT-proBNP) level, greater left ventricular (LV) mass, higher prevalence of severe diastolic dysfunction, LV ejection fraction < 35%, severe renal dysfunction, and more men compared with the low hs-TnT group. All-cause mortality during follow-up after TAVR was significantly higher among patients who had hs-TnT ≥ 39.4 pg/mL compared with those who did not (mortality rate at 2 years post-TAVR: 12.3% vs. 4.1%, p = 0.010). Multivariate analysis identified 1-year hs-TnT ≥ 39.4 pg/mL (hazard ratio 2.93, 95% CI 1.91–4.49, p < 0.001), NT-proBNP level > 300 pg/mL, male sex, an eGFR < 60 mL/min/1.73 m2 and chronic obstructive pulmonary disease as independent risk factors for long-term mortality after TAVR. Conclusions Elevated hs-TnT concentrations at 1-year after TAVR were associated with a higher long-term mortality. Graphic abstract

Association of High-Sensitivity Troponin T With Left Ventricular Dysfunction in Ankylosing Spondylitis

2020 ◽  
Vol 26 (3) ◽  
pp. 87-93 ◽  
Author(s):  
Serdar Turkmen ◽  
Lutfu Askin ◽  
Kader Eliz Uzel ◽  
Huseyin Nacar ◽  
Veysi Kavalci ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T

Association between high-sensitivity troponin T, left ventricular hypertrophy, and myocardial performance index

Herz ◽  
2015 ◽  
Vol 40 (7) ◽  
pp. 1004-1010 ◽  
Author(s):  
Onur Kaypakli ◽  
Mustafa Gür ◽  
Mehmet Yavuz Gözükara ◽  
Hakan Uçar ◽  
Ali Kivrak ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Performance Index ◽  
Ventricular Hypertrophy ◽  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T

scholarly journals High Sensitivity Troponin T as Complementary Modality for Determining Doxorubicin Regimen Cardiotoxicity in Non-Hodgkin Lymphoma Patients

2020 ◽  
Author(s):  
Ami Ashariati Prayogo ◽  
Satriyo Dwi Suryantoro ◽  
Merlyna Savitri ◽  
Winona May Hendrata ◽  
Andi Yasmin Wijaya ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Cellular Damage ◽  
Left Ventricular Ejection ◽  
Non Hodgkin Lymphoma ◽  
High Sensitivity Troponin ◽  
Significant Difference ◽  
High Sensitivity Troponin T

Purpose: This study aims to evaluate the role of high-sensitivity troponin T (hsTnT) as a complementary tool for determining cardiotoxicity in non-Hodgkin lymphoma (NHL) patients receiving cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) regimen chemotherapy. Methods: We included 35 patients diagnosed with NHL who received CHOP chemotherapy. Left ventricular ejection fraction (LVEF) and hsTnT were measured at two time points: before the first cycle (pre-test) and after the fourth cycle (post-test). The LVEF and hsTnT were analysed using IBM SPSS version 24 through the paired-sample T-test, Wilcoxon signed-rank test, Pearson’s correlation and Spearman’s correlation. Results: There was a significant difference in both LVEF and hsTnT between pre-chemotherapy and post-4th chemotherapy cycles (p = 0.001). However, more contrast difference from the baseline value of hsTnT compared to LVEF could be observed. LVEF did not detect any deterioration in myocardial function. However, 10 out of 35 subjects exhibit hsTnT higher than the 99th percentile of the population (>14 pg/ml), suggesting that myocardial injury (MI) could be detected. There was no correlation between LVEF and hsTnT (p > 0.05). Conclusion: HsTnT, together with LVEF, could complement each other and offer better coverage for detecting cardiotoxicity during the administration of CHOP in NHL patients. An insignificant correlation between hsTnT and LVEF showed that cardiotoxicity existed in a broad spectrum including cellular damage and functional impairment, as hsTnT represents cellular damage, and LVEF reflects heart functional capacity.

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