scholarly journals Role of the Chinese Herbal Medicine Xianhuayin on the Reversal of Premalignant Mucosal Lesions in the Golden Hamster Buccal Pouch

2010 ◽  
Vol 2 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Yan‐zhi Xu ◽  
Yong‐le Qiu ◽  
Zhi‐guang An ◽  
Feng‐ying Yang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Golden Hamster ◽  
Chinese Herbal ◽  
Hamster Buccal Pouch ◽  
Mucosal Lesions

scholarly journals Network Pharmacology: A New Approach for Chinese Herbal Medicine Research

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gui-biao Zhang ◽  
Qing-ya Li ◽  
Qi-long Chen ◽  
Shi-bing Su
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Target Prediction ◽  
Network Pharmacology ◽  
Multiple Targets ◽  
Medicine Research ◽  
Chinese Herbal ◽  
Long Time ◽  
Effective Drugs

The dominant paradigm of “one gene, one target, one disease” has influenced many aspects of drug discovery strategy. However, in recent years, it has been appreciated that many effective drugs act on multiple targets rather than a single one. As an integrated multidisciplinary concept, network pharmacology, which is based on system biology and polypharmacology, affords a novel network mode of “multiple targets, multiple effects, complex diseases” and replaces the “magic bullets” by “magic shotguns.” Chinese herbal medicine (CHM) has been recognized as one of the most important strategies in complementary and alternative medicine. Though CHM has been practiced for a very long time, its effectiveness and beneficial contribution to public health has not been fully recognized. Also, the knowledge on the mechanisms of CHM formulas is scarce. In the present review, the concept and significance of network pharmacology is briefly introduced. The application and potential role of network pharmacology in the CHM fields is also discussed, such as data collection, target prediction, network visualization, multicomponent interaction, and network toxicology. Furthermore, the developing tendency of network pharmacology is also summarized, and its role in CHM research is discussed.

scholarly journals Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenqian Guo ◽  
Han Ma ◽  
Chong-Zhi Wang ◽  
Jin-Yi Wan ◽  
Haiqiang Yao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Bioactive Compound ◽  
Plant Responses ◽  
Therapeutic Effects ◽  
Health Maintenance ◽  
Cellular Processes ◽  
Chinese Herbal

Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance.

Sign in / Sign up

Export Citation Format

Share Document