scholarly journals Adipose tissue-derived progenitor cells and cancer

2010 ◽  
Vol 2 (5) ◽  
pp. 103 ◽  
Author(s):  
Yan Zhang
Keyword(s):  
Adipose Tissue ◽  
Progenitor Cells

Efficacy and Safety of Treatment of Complex Idiopathic Fistula-in-Ano Using Autologous Centrifuged Adipose Tissue Containing Progenitor Cells

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Simona Ascanelli ◽  
Paolo Zamboni ◽  
Diana Campioni ◽  
Maria Grazia Sibilla ◽  
Laura Chimisso ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Progenitor Cells ◽  
Efficacy And Safety ◽  
Fistula In Ano

scholarly journals Cytometric analysis of adipose tissue reveals increments of adipocyte progenitor cells after weight loss induced by bariatric surgery

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jesús García-Rubio ◽  
Josefa León ◽  
Anaïs Redruello-Romero ◽  
Esther Pavón ◽  
Antonio Cozar ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Progenitor Cells

scholarly journals The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

2018 ◽  
Vol 237 (1) ◽  
pp. 15-27 ◽  
Author(s):  
Patricia K Russell ◽  
Salvatore Mangiafico ◽  
Barbara C Fam ◽  
Michele V Clarke ◽  
Evelyn S Marin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Androgen Receptor ◽  
Progenitor Cells ◽  
Fat Mass ◽  
Elevated Serum ◽  
Gene Replacement ◽  
Whole Body ◽  
Clinical Aspects ◽  
Mesenchymal Progenitor Cells

It is well established that testosterone negatively regulates fat mass in humans and mice; however, the mechanism by which testosterone exerts these effects is poorly understood. We and others have shown that deletion of the androgen receptor (AR) in male mice results in a phenotype that mimics the three key clinical aspects of hypogonadism in human males; increased fat mass and decreased bone and muscle mass. We now show that replacement of the Ar gene specifically in mesenchymal progenitor cells (PCs) residing in the bone marrow of Global-ARKO mice, in the absence of the AR in all other tissues (PC-AR Gene Replacements), completely attenuates their increased fat accumulation. Inguinal subcutaneous white adipose tissue and intra-abdominal retroperitoneal visceral adipose tissue depots in PC-AR Gene Replacement mice were 50–80% lower than wild-type (WT) and 75–90% lower than Global-ARKO controls at 12 weeks of age. The marked decrease in subcutaneous and visceral fat mass in PC-AR Gene Replacements was associated with an increase in the number of small adipocytes and a healthier metabolic profile compared to WT controls, characterised by normal serum leptin and elevated serum adiponectin levels. Euglycaemic/hyperinsulinaemic clamp studies reveal that the PC-AR Gene Replacement mice have improved whole-body insulin sensitivity with higher glucose infusion rates compared to WT mice and increased glucose uptake into subcutaneous and intra-abdominal fat. In conclusion, these data provide the first evidence for an action of androgens via the AR in mesenchymal bone marrow PCs to negatively regulate fat mass and improve metabolic function.

Abstract 50: A Phase I Clinical Trial Evaluating the Safety of With Allogeneic Adipose Tissue-derived Multilineage Progenitor Cells-transplantation Therapy in Homozygous Familial Hypercholesterolemia Patients

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Masahiro Koseki ◽  
Shizuya Yamashita
Keyword(s):  
Clinical Trial ◽  
Liver Transplantation ◽  
Adipose Tissue ◽  
Progenitor Cells ◽  
Familial Hypercholesterolemia ◽  
Ldl Cholesterol ◽  
Ldl Receptor ◽  
Ldl Apheresis ◽  
Definitive Therapy ◽  
Transplantation Therapy

Familial hypercholesterolemia (FH) is an inherited disorder, mainly caused by defects in low-density lipoprotein (LDL) receptor gene. The patients are characterized by high LDL cholesterol levels in the blood and premature cardiovascular disease. Although most of heterozygous FH patients are usually treated with statin, ezetimibe and bile acid sequestrants, homozygous FH patients are resistant to drug therapy. Therefore, in Japan, many of homozygous FH patients are treated by LDL-apheresis. LDL-apheresis is a great procedure to remove LDL cholesterol from the blood and contribute to improve prognosis of homozygous FH patients. However, the effect of removing LDL cholesterol is temporary and still not enough. As a definitive therapy, liver transplantation therapy could be one of options to recover LDL receptor, but donor is limited in Japan. Therefore, based on the increase of the evidence about the safety of mesenchymal stem cells and percutaneous transhepatic portal approach in islet transplantation, we have developed a cell transplantation therapy with allogeneic adipose tissue-derived multilineage progenitor cells (ADMPCs), as an alternative treatment instead of liver transplantation. Our group has already proved that xenogenic transplantation of human ADMPCs into Watanabe heritable hyperlipidemic rabbits resulted in significant reductions in total cholesterol, and the reductions were observed within 4 weeks and maintained for 12 weeks. These results suggested that hADMPC transplantation could correct the metabolic defects and be a novel therapy for inherited liver diseases. Here, we report a protocol for the first-in-human clinical trial, which has been approved by the institutional review board and Ministry of Health, Labour and Welfare, Japan.

Adipose Tissue and Progenitor Cells for Cartilage Formation

2014 ◽  
pp. 1-12
Author(s):  
Fabio Valerio Sciarretta ◽  
Claudio Ascani
Keyword(s):  
Adipose Tissue ◽  
Progenitor Cells ◽  
Cartilage Formation

scholarly journals Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Science ◽  
2019 ◽  
Vol 364 (6438) ◽  
pp. eaav2501 ◽  
Author(s):  
David Merrick ◽  
Alexander Sakers ◽  
Zhazira Irgebay ◽  
Chihiro Okada ◽  
Catherine Calvert ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Progenitor Cells ◽  
Transforming Growth Factor ◽  
De Novo ◽  
Mesenchymal Cell ◽  
Transforming Growth Factor Β ◽  
Cell Types ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Dipeptidyl Peptidase 4

Metabolic health depends on the capacity of adipose tissue progenitor cells to undergo de novo adipogenesis. The cellular hierarchy and mechanisms governing adipocyte progenitor differentiation are incompletely understood. Through single-cell RNA sequence analyses, we show that the lineage hierarchy of adipocyte progenitors consists of distinct mesenchymal cell types that are present in both mouse and human adipose tissues. Cells marked by dipeptidyl peptidase–4 (DPP4)/CD26 expression are highly proliferative, multipotent progenitors. During the development of subcutaneous adipose tissue in mice, these progenitor cells give rise to intercellular adhesion molecule–1 (ICAM1)/CD54–expressing (CD54+) committed preadipocytes and a related adipogenic cell population marked by Clec11a and F3/CD142 expression. Transforming growth factor–β maintains DPP4+ cell identity and inhibits adipogenic commitment of DPP4+ and CD142+ cells. Notably, DPP4+ progenitors reside in the reticular interstitium, a recently appreciated fluid-filled space within and between tissues, including adipose depots.

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