Virtual Analysis of Compliant Parts

Drug design and development is an interactive process includes process like molecular docking which involves virtual analysis of the derivatives against the protein targets. COXS are the groups of enzymes which plays vital role in the human process. COX II is important enzyme involved in the inflammation and can act as potential target for development of the potent anti-inflammatory agents. Pyrimidine is one of the most utilized heterocyclic scaffolds for the development of therapeutic agents due to its role in the nucleic acid and proteins in the human body. The present communication deals with docking analysis of virtually designed 58 condensed pyrimidine derivatives as potential anti-inflammatory agents. The derivatives were designed and virtually screened via molecular docking against the COX-II crystal structure to identically the potential leads.

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Virtual analysis of stresses in human teeth restored with esthetic posts

Materials Research ◽

10.1590/s1516-14392008000400014 ◽

2008 ◽

Vol 11 (4) ◽

pp. 459-463 ◽

Cited By ~ 5

Author(s):

Martha Vasconcellos Amarante ◽

Marcos Venicius Soares Pereira ◽

Fathi Aref Ibrahim Darwish ◽

Arnaldo Freitas Camarão

Keyword(s):

Human Teeth ◽

Virtual Analysis

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Fixturing of Compliant Parts Using a Matrix of Reconfigurable Pins

Journal of Manufacturing Science and Engineering ◽

10.1115/1.1314599 ◽

1999 ◽

Vol 122 (4) ◽

pp. 766-772 ◽

Cited By ~ 16

Author(s):

Daniel F. Walczyk ◽

Randy S. Longtin

Keyword(s):

Low Cost ◽

Metal Composite ◽

Lateral Loads ◽

Load Carrying ◽

Mechanical Models ◽

Computer Controlled ◽

Compliant Parts ◽

Plastic Parts ◽

Machining Operations ◽

Rigid Platen

Commercially-available reconfigurable fixtures, used for holding compliant sheet metal, composite and plastic parts during secondary machining operations, are extremely expensive and overly-complicated devices. A computer-controlled, reconfigurable fixturing device (RFD) concept for compliant parts, based on a matrix of individually-stoppable pins lowered by a single rigid platen, has been developed as a simple and low-cost design alternative to commercially-available devices. Two different approaches to stopping and clamping individual pins have been investigated: a combination electromagnet assist and gas springs compressed with a toggle mechanism, and a pneumatic clamp. Simple mechanical models have been developed for predicting the stopping and clamping performance of both designs including pin positioning accuracy, vertical load-carrying capacity of a pin, and deflection of a pin subjected to lateral loads. An RFD prototype, consisting of a single pin actuated by a servoed platen, has been designed, built and tested. It has demonstrated the feasibility of this new RFD design. [S1087-1357(00)02204-8]

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Fault Failure Diagnosis for Compliant Assembly Structures Using Statistical Modal Analysis

Manufacturing Science and Engineering, Parts A and B ◽

10.1115/msec2006-21086 ◽

2006 ◽

Author(s):

Prakash ◽

D. Ceglarek ◽

M. K. Tiwari

Keyword(s):

Modal Analysis ◽

Failure Diagnosis ◽

Industrial Case Study ◽

Mapping Procedure ◽

Compliant Part ◽

Compliant Assembly ◽

Dimensional Variation ◽

Compliant Parts ◽

Deformation Modes

This paper develops a new diagnostics methodology for N-2-1 fixtures used in assembly processes with compliant parts. The developed methodology includes: (i) the predetermined CAD-based dimensional variation fault patterns model; (ii) data-based dimensional variation fault model; and (iii) the fault mapping procedure isolating the unknown fault. The CAD-based variation fault pattern model is based on the piece-wise linear bi-partitioning of compliant part into deformed (faulty) and un-deformed regions. Data-based dimensional variation fault models are based on the statistical modal analysis (SMA) which allow to model part deformation with varying number of deformation modes. It is proved in the paper that these independent deformation modes are equivalent to the CAD-based faults models obtained in (i). The fault mapping procedure allows to diagnose the unknown fault by comparing the unknown fault variation pattern obtained from the SMA model with one of the predetermined CAD-based fault patterns. One industrial case study from an automotive roof framing assembly illustrates the proposed method.

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Assembly Variation Analysis of Aircraft Panels under Part-to-part Locating Scheme

International Journal of Aerospace Engineering ◽

10.1155/2019/9563596 ◽

2019 ◽

Vol 2019 ◽

pp. 1-15 ◽

Cited By ~ 3

Author(s):

Xia Liu ◽

Luling An ◽

Zhiguo Wang ◽

Changbai Tan ◽

Xiaoping Wang ◽

...

Keyword(s):

Elastic Deformation ◽

Assembly Process ◽

Variation Analysis ◽

Kinematic Theory ◽

Statistical Variation ◽

Variation Propagation ◽

Fixed Part ◽

Compliant Parts ◽

Aircraft Panels

A typical aircraft panel is the assembly consisting of a multitude of thin and lightweight compliant parts. In panel assembly process, part-to-part locating scheme has been widely adopted in order to reduce fixtures. By this locating scheme, a part is located onto the pre-fixed part/subassembly by determinant assembly (DA) holes, and temporary fasteners (e.g., spring pin) are used for joining these DA hole-hole pairs. The temporary fasteners can fasten DA hole-hole pairs in the axial and radial directions of DA holes. The fastening in the radial directions is realized by the expansion of temporary fasteners. Although the usage of temporary fasteners helps reduce the positional differences between hole-hole pairs, their clamping forces thereby may lead to elastic deformation of compliant parts/subassemblies. Limited research has been conducted on such elastic deformation produced by temporary fastener and its influence on assembly dimensional quality. This paper proposes a novel rigid-compliant variation analysis method for aircraft panel assembly, incorporating the deformation in part-to-part locating process. Based on the kinematic theory and linear elasticity deformation assumption, the variation propagation through the locating process, as well as the entire assembly process of an aircraft panel, is formulated. Then, the statistical variation analysis is performed with Monte Carlo (MC) simulation. Finally, the proposed method is validated by a case study. The result shows the deformation in the part-to-part locating process significantly impacts the assembly variations, and our method can provide a more accurate and reliable prediction.

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Convex optimization techniques in compliant assembly simulation

Optimization and Engineering ◽

10.1007/s11081-020-09493-z ◽

2020 ◽

Vol 21 (4) ◽

pp. 1665-1690

Author(s):

Maria Stefanova ◽

Olga Minevich ◽

Stanislav Baklanov ◽

Margarita Petukhova ◽

Sergey Lupuleac ◽

...

Keyword(s):

Large Scale ◽

Hessian Matrix ◽

Linear Complementarity Problems ◽

Contact Problems ◽

Optimization Methods ◽

Optimization Techniques ◽

Active Set ◽

Assembly Simulation ◽

The Matrix ◽

Compliant Parts

Abstract A special class of quadratic programming (QP) problems is considered in this paper. This class emerges in simulation of assembly of large-scale compliant parts, which involves the formulation and solution of contact problems. The considered QP problems can have up to 20,000 unknowns, the Hessian matrix is fully populated and ill-conditioned, while the matrix of constraints is sparse. Variation analysis and optimization of assembly process usually require massive computations of QP problems with slightly different input data. The following optimization methods are adapted to account for the particular features of the assembly problem: an interior point method, an active-set method, a Newton projection method, and a pivotal algorithm for the linear complementarity problems. Equivalent formulations of the QP problem are proposed with the intent of them being more amenable to the considered methods. The methods are tested and results are compared for a number of aircraft assembly simulation problems.

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