Multiple Thick Nodular Melanoma: Differentiating Multiple Primaries from the Metastasis of a Previous Single Lesion

1989 ◽

Vol 47 ◽

pp. 1100-1101

Author(s):

D.C. Dominguez ◽

J.T. Ellzey

Keyword(s):

Caloric Intake ◽

Volume Density ◽

Controlled Study ◽

Control Group ◽

Numerical Density ◽

Cacodylate Buffer ◽

Paired Control ◽

Experimental Group ◽

Liver Peroxisomes ◽

Single Lesion

Peroxisomes which participate in 1ipid metabolism have been shown to be altered in several metabolic disorders and toxic conditions. In alcoholic liver disease, the single lesion most frequently found is lipid accumu1ation in hepatocytes. However, the mechanisms for this 1ipid accumu1ation are not clear. The occurrence of modifications of liver peroxisomes due to excess alcohol consumption has not been subjected to a controlled study. We utilized a combination of cytochemica1 and morphometrictechniques to study the size and number of liver peroxisomes in rats fed an alcohol-supplemented diet compared to those of matched-paired control animals.Male Sprague-Daw1ey rats (400-500 g) received a liquid diet. The experimental group (N = 5/group) was fed a diet containing 30% ethanol-derived calories (EDC) and the control group was fed an isocaloric diet to 30% EDC. A pair feeding procedure was employed to control for caloric intake. Small pieces of liver randomly selected, were fixed in 2.3% -glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 7.2, incubated in a DAB medium and postfixed with. 2% aqueous osmium tetroxide. EM photographs were taken from sections of 3 tissue blocks from each sample (7,200X) with a Zeiss EM10-A (60 kV). With the use of a point counting method and a digital planimeter the volume density (Vv) and numerical density (Nv) were determined.

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Combined dermatofibroma: co-existence of two or more variant patterns in a single lesion

Histopathology ◽

10.1046/j.1365-2559.2000.00901.x ◽

2000 ◽

Vol 36 (6) ◽

pp. 529-539 ◽

Cited By ~ 44

Author(s):

B G Zelger ◽

A Sidoroff ◽

B Zelger

Keyword(s):

Single Lesion

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Nodular Melanoma Signs Not as Simple as ABCs

Internal Medicine News ◽

10.1016/s1097-8690(05)72045-x ◽

2005 ◽

Vol 38 (19) ◽

pp. 48

Author(s):

NANCY WALSH

Keyword(s):

Nodular Melanoma

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Actinic keratoses: when and how to treat a single lesion

Giornale Italiano di Dermatologia e Venereologia ◽

10.23736/s0392-0488.18.06082-0 ◽

2020 ◽

Vol 155 (4) ◽

Author(s):

Anna Carbone ◽

Vitaliano Silipo ◽

Laura Eibenschutz ◽

Paolo Piemonte ◽

Angela Ferrari ◽

...

Keyword(s):

Actinic Keratoses ◽

Single Lesion

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Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma

BMC Research Notes ◽

10.1186/s13104-021-05623-7 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Ridwan Dwi Saputro ◽

Hanggoro Tri Rinonce ◽

Yayuk Iramawasita ◽

Muhammad Rasyid Ridho ◽

Maria Fransiska Pudjohartono ◽

...

Keyword(s):

Prognostic Factor ◽

Median Survival ◽

Therapy Response ◽

Mrna Levels ◽

Strongly Correlated ◽

Clinicopathologic Characteristics ◽

Tissue Samples ◽

Nodular Melanoma ◽

Melanoma Patients ◽

Melanoma Tissue

Abstract Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue with clinicopathologic characteristics and survival in Indonesian primary nodular melanoma patients. Results Thirty-one tissue samples were obtained; two were excluded from survival analysis due to Breslow depth of less than 4 mm. The median survival of upregulated and normoregulated PD-L1-patients were 15.800 ± 2.345 and 28.945 ± 4.126 months, respectively. However, this difference was not significant statistically (p = 0.086). Upregulated and normoregulated NKG2A patients differed very little in median survival time (25.943 ± 7.415 vs 26.470 ± 3.854 months; p = 0.981). Expression of PD-L1 and NKG2A were strongly correlated (rs: 0.787, p < 0.001). No clinicopathologic associations with PD-L1 and NKG2A mRNA levels were observed. These results suggest that PD-L1 may have potential as a prognostic factor. Although an unlikely prognostic factor, NKG2A may become an adjunct target for therapy. The strong correlation between PD-L1 and NKG2A suggests that anti-PD-1 and anti-NKG2A agents could be effective in patients with PD-L1 upregulation. The mRNA levels of these two genes may help direct choice of immunotherapy and predict patient outcomes.

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Osteosarcoma: a review of current and future therapeutic approaches

BioMedical Engineering OnLine ◽

10.1186/s12938-021-00860-0 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Xin Zhao ◽

Qirui Wu ◽

Xiuqing Gong ◽

Jinfeng Liu ◽

Yujie Ma

Keyword(s):

Bimodal Distribution ◽

Therapeutic Approaches ◽

Rapid Disease Progression ◽

New Ideas ◽

Degree Of Malignancy ◽

Primary Bone ◽

Children And Young Adults ◽

High Degree ◽

Single Lesion ◽

Tubular Bones

AbstractOsteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.

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