Nodular Melanoma Signs Not as Simple as ABCs

Abstract Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue with clinicopathologic characteristics and survival in Indonesian primary nodular melanoma patients. Results Thirty-one tissue samples were obtained; two were excluded from survival analysis due to Breslow depth of less than 4 mm. The median survival of upregulated and normoregulated PD-L1-patients were 15.800 ± 2.345 and 28.945 ± 4.126 months, respectively. However, this difference was not significant statistically (p = 0.086). Upregulated and normoregulated NKG2A patients differed very little in median survival time (25.943 ± 7.415 vs 26.470 ± 3.854 months; p = 0.981). Expression of PD-L1 and NKG2A were strongly correlated (rs: 0.787, p < 0.001). No clinicopathologic associations with PD-L1 and NKG2A mRNA levels were observed. These results suggest that PD-L1 may have potential as a prognostic factor. Although an unlikely prognostic factor, NKG2A may become an adjunct target for therapy. The strong correlation between PD-L1 and NKG2A suggests that anti-PD-1 and anti-NKG2A agents could be effective in patients with PD-L1 upregulation. The mRNA levels of these two genes may help direct choice of immunotherapy and predict patient outcomes.

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Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2016.01.022 ◽

2016 ◽

Vol 20 ◽

pp. 84-86

Author(s):

Domagoj Eljuga ◽

Ivan Milas ◽

Iva Kirac ◽

Mladen Stanec ◽

Danko Velimir Vrdoljak

Keyword(s):

Case Report ◽

Primary Closure ◽

Melanocytic Nevus ◽

Congenital Melanocytic Nevus ◽

Nodular Melanoma

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Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma

The Journal of Dermatology ◽

10.1111/j.1346-8138.2010.01140.x ◽

2010 ◽

Vol 38 (1) ◽

pp. 10-15 ◽

Cited By ~ 24

Author(s):

Fergal J. MOLONEY ◽

Scott W. MENZIES

Keyword(s):

Nodular Melanoma ◽

Key Points

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RSK1 Activation Promotes Invasion in Nodular Melanoma

American Journal Of Pathology ◽

10.1016/j.ajpath.2014.11.021 ◽

2015 ◽

Vol 185 (3) ◽

pp. 704-716 ◽

Cited By ~ 11

Author(s):

Amel Salhi ◽

Joshua A. Farhadian ◽

Keith M. Giles ◽

Eleazar Vega-Saenz de Miera ◽

Ines P. Silva ◽

...

Keyword(s):

Nodular Melanoma

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BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival

British Journal of Cancer ◽

10.1038/bjc.2016.44 ◽

2016 ◽

Vol 114 (7) ◽

pp. 801-808 ◽

Cited By ~ 27

Author(s):

Emilia Hugdahl ◽

May Britt Kalvenes ◽

Hanne E Puntervoll ◽

Rita G Ladstein ◽

Lars A Akslen

Keyword(s):

Braf V600e ◽

Nodular Melanoma

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Nodular melanoma presenting as an exophytic subungual mass

Scottish Medical Journal ◽

10.1177/0036933018755938 ◽

2018 ◽

Vol 63 (1) ◽

pp. 32-34 ◽

Cited By ~ 2

Author(s):

B Finlay ◽

T Ramachandren ◽

K Hussey ◽

S Parkyn ◽

K Meyer ◽

...

Keyword(s):

Delayed Diagnosis ◽

Interesting Case ◽

High Index ◽

Nodular Melanoma ◽

Diagnostic Pitfall ◽

One Year ◽

High Index Of Suspicion ◽

Subungual Melanoma

Despite being recognised and reported in the literature for decades, subungual melanoma of the foot remains a diagnostic pitfall, with it commonly being mistaken for benign conditions. We present an interesting case of delayed diagnosis of subungual melanoma of the hallux that was misdiagnosed in the community for over one year. With melanoma being the fourth most commonly diagnosed cancer in Australia in 2013, this case serves as a reminder to all clinicians about the importance of maintaining a high index of suspicion for melanoma of the foot.

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Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma

10.21203/rs.3.rs-322309/v1 ◽

2021 ◽

Author(s):

Ridwan Dwi Saputro ◽

Hanggoro Tri Rinonce ◽

Yayuk Iramawasita ◽

Muhammad Rasyid Ridho ◽

Maria Fransiska Pudjohartono ◽

...

Keyword(s):

Target Genes ◽

Therapy Response ◽

Mrna Levels ◽

Independent Predictive Factor ◽

Clinicopathologic Characteristics ◽

Tissue Samples ◽

Nodular Melanoma ◽

Expression Levels ◽

Melanoma Tissue

Abstract Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue and clinicopathologic characteristics and survival in Indonesian patients with primary nodular melanoma. Results Thirty-two tissue samples were analyzed. Upregulated PD-L1 was associated with shorter overall survival (hazard ratio: 2.930; 95% confidence interval: 1.011–8.489, p = 0.048) compared with patients with normoregulated PD-L1. A significant positive correlation was found between the expression levels of PD-L1 and NKG2A (rs: 0.768, p < 0.001). However, no clinicopathologic associations with PD-L1 and NKG2A mRNA levels were statistically proven. Comparison with other studies suggested that the choice of adjuvant therapy and the presence of TILs affect the prognostic role of PD-L1 expression. NKG2A was not proven to be an independent predictive factor but may become an adjunct target for therapy. The strong correlation between PD-L1 and NKG2A suggests that anti-PD-1 and anti-NKG2A agents could be effective in patients with PD-L1 upregulation. The combination of the mRNA levels of these two target genes may provide a novel prognostic and therapeutic direction for immunotherapy.

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