Intraoperative Use of Epsilon Amino Caproic Acid and Tranexamic Acid in Surgeries Performed Under Cardiopulmonary Bypass: a Comparative Study To Assess Their Impact On Reopening Due To Postoperative Bleeding

The aim of this paper is to assess the efficiency and safety of the tranexamic acid in reducing blood loss and the need for transfusion in patients diagnosed with staghorn calculi treated by percutaneous nephrolithotomy. Percutaneous nephrolithotomy (PCNL) is a minimally invasive technique used for large kidney stones. Hemorrhagic complications and urinary sepsis are serious complications associated with this type of surgery. Tranexamic acid is an antifibrinolytic drug that has the property of reducing intra or postoperative bleeding. The experience with tranexamic acid in preventing blood loss during percutaneous nephrolithotomy for is limited. The use tranexamic acid in percutaneous nephrolithotomy for staghorn type stones is safe and is associated with reduced blood loss and a lower transfusion rate.

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The Control of Bloodloss During Percutanerous Nephrolithotomy Using Tranexamic Acid

Revista de Chimie ◽

10.37358/rc.18.10.6612 ◽

2018 ◽

Vol 69 (10) ◽

pp. 2728-2730

Author(s):

Raluca Costina Barbilian ◽

Victor Cauni ◽

Bogdan Mihai ◽

Ioana Buraga ◽

Mihai Dragutescu ◽

...

Keyword(s):

Tranexamic Acid ◽

Percutaneous Nephrolithotomy ◽

Kidney Stones ◽

Postoperative Bleeding ◽

Invasive Technique ◽

Transfusion Rate ◽

Renal Lithiasis ◽

Percutaneous Approach ◽

Transfusion Requirements ◽

Urinary Sepsis

The aim of this study is to assess the efficiency and safety of the tranexamic acid in reducing hemmorrhagic complications and transfusion requirements in patients with renal lithiasis treated by percutaneous approach. Percutaneous nephrolithotomy (PCNL) is a minimally invasive technique used for large kidney stones (]20mm). Urinary sepsis and intra or postoperative bleeding are the very serious complications associated with this type of procedure. Tranexamic acid is used in the treatment of many haemorrhagic conditions. The experience with tranexamic acid in preventing bloodloss during percutaneous nephrolithotomy is very limited. The use tranexamic acid in percutaneous nephrolithotomy is safe and is associated with reduced blood loss and a lower transfusion rate.

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Assessment the role of tranexamic acid in prevention of postpartum hemorrhage

Ain-Shams Journal of Anesthesiology ◽

10.1186/s42077-021-00154-6 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Nevein Gerges Fahmy ◽

Fahmy Saad Latif Eskandar ◽

Walid Albasuony Mohammed Ahmed Khalil ◽

Mohammed Ibrahim Ibrahim Sobhy ◽

Amin Mohammed Al Ansary Amin

Keyword(s):

Blood Loss ◽

Cesarean Section ◽

Tranexamic Acid ◽

Postpartum Hemorrhage ◽

Postoperative Bleeding ◽

Control Group ◽

Study Group ◽

Mortality And Morbidity ◽

Lower Segment Cesarean Section ◽

Prophylactic Use

Abstract Background Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. It is believed that hemostatic imbalance secondary to release of tissue plasminogen activator (tPA) and subsequent hyperfibrinolysis plays a major role in PPH pathogenesis. Antifibrinolytic drugs such as tranexamic acid (TXA) are widely used in hemorrhagic conditions associated with hyperfibrinolysis. TXA reduced maternal death due to PPH and its use as a part of PPH treatment is recommended, and in recent years, a number of trials have investigated the efficacy of prophylactic use of TXA in reducing the incidence and the severity of PPH. The study is aiming to assess the efficacy of tranexamic acid in reducing blood loss throughout and after the lower segment cesarean section and reducing the risk of postpartum hemorrhage. Results The amount of blood loss was significantly lower in the study group than the control group (416.12±89.95 and 688.68±134.77 respectively). Also the 24-h postoperative hemoglobin was significantly higher in the study group (11.66±0.79 mg/dl) compared to the control group (10.53±1.07mg/dl), and the 24-h postoperative hematocrit value was significantly higher in the study group (34.99±2.40) compared to control (31.62±3.22). Conclusion Prophylactic administration of tranexamic acid reduces intraoperative and postoperative bleeding in cesarean section and the incidence of postpartum hemorrhage.

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