scholarly journals Diagnosing and treating rare lesions in a low resource setting: lessons from a hybrid epithelioid trophoblastic tumor and choriocarcinoma

2018 ◽  
Vol 51 (4) ◽  
pp. 196-199
Author(s):  
Patrick K Akakpo ◽  
Kofi Ulzen-Appiah ◽  
Evans Agbeno ◽  
Leonard Derkyi-Kwarteng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Diagnosis ◽  
Low Resource ◽  
Trophoblastic Tumor ◽  
Resource Setting ◽  
Low Resource Setting ◽  
Epithelioid Trophoblastic Tumor ◽  
Β Hcg

Objective: To raise awareness of the existence of a rare type of malignant trophoblastic tumor and discuss the diagnostic challenges and management of this lesion in a low resource setting.Case report and intervention: A 35 -year -old G6P3 woman was referred to our facility on account of persistent vaginal bleeding due to a suspected incomplete miscarriage with a cervical mass. Her serum β-HCG was elevated (36,900 mIU/ml) and examination showed a bleeding cervical mass. An initial histopathological diagnosis of moderately differentiated squamous cell carcinoma was reviewed to epithelioid trophoblastic tumor resulting in an extra-fascial hysterectomy. A final histopathological diagnosis of hybrid Epithelioid Trophoblastic Tumor and Choriocarcinoma (ETT/CC) was made after external review and immunohistochemistry. She received subsequent chemotherapy.Conclusion: Epithelioid trophoblastic tumor and its hybrids are difficult to diagnose. They may be diagnosed as moderately differentiated squamous cell carcinoma especially in low resource settings where cervical squamous cell carcinoma is relatively more common. A high index of suspicion, a serum β HCG test and close collaborationbetween clinicians and pathologists can help make the diagnosis.Funding: NoneKeywords: Epithelioid trophoblastic tumour, choriocarcinoma, diagnostic challenges, low resource setting

Epithelioid Trophoblastic Tumor: An Outcome-Based Literature Review of 78 Reported Cases

2013 ◽  
Vol 23 (7) ◽  
pp. 1334-1338 ◽  
Author(s):  
Xiaofei Zhang ◽  
Weiguo Lü ◽  
Bingjian Lü
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Figo Stage ◽  
Lower Uterine Segment ◽  
Reproductive Age ◽  
Small Data ◽  
Data Set ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor

ObjectivesEpithelioid trophoblastic tumor (ETT) is very rare; and therefore, a substantially increased data set is unlikely to be obtained in the near future. This analysis aimed to assess the effects of current management on clinical outcomes and to identify potential prognostic indicators in ETT.MethodsWe applied a literature search using PubMed to analyze the clinical data of 78 published cases of ETT.ResultsWomen with ETT present at reproductive age (mean ± SD, 37.1 ± 8.7 years) and have a slightly to moderately elevated serum β-human chorionic gonadotropin (median, 665 IU/L). Epithelioid trophoblastic tumor is frequently present in the lower uterine segment/cervix (26/58 cases) and can be misdiagnosed as squamous cell carcinoma (6/26). Lung is the most common extrauterine site of ETT (5/11 with uterine ETT and 10/20 without uterine ETT). Kaplan-Meier analysis indicates that chemotherapy (surgery with postoperative chemotherapy vs surgery alone) is associated with increased ETT relapse (P= 0.005), even after stratification by International Federation of Gynecology and Obstetrics (FIGO) stage (P= 0.008); but FIGO stage remains the only significant prognostic indicator for ETT (P= 0.015).ConclusionsThis analysis confirms the hypothetical chemotherapy resistance and prognostic value of FIGO staging in ETT. These findings remain tentative given the small data set available for analysis and the reporting bias from these published cases; however, they may confer a risk-adapted therapy. Finally, both gynecologists and pathologists should be alert to the potential misdiagnosis of squamous cell carcinoma when ETT is present in the lower uterine segment/cervix.

scholarly journals Differentiating Squamous Cell Carcinoma of the Cervix and Epithelioid Trophoblastic Tumor

2011 ◽  
Vol 21 (5) ◽  
pp. 918-922 ◽  
Author(s):  
Sara Jordan ◽  
Leslie M. Randall ◽  
Yevgeniy Karamurzin ◽  
Pamela Ward ◽  
Fritz Lin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Trophoblastic Tumor ◽  
Epithelioid Trophoblastic Tumor

scholarly journals Epithelial trophoblastic tumor associated with in situ squamous cell carcinoma of the cervix

2010 ◽  
Vol 46 (2) ◽  
Author(s):  
Eduardo Cambruzzi ◽  
Karla Lais Pêgas ◽  
Dennis Baroni Cruz ◽  
Pedro Guilherme Schaefer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Trophoblastic Tumor

scholarly journals Squamous cell carcinoma mimicking a wart

2021 ◽  
Vol 12 (4) ◽  
pp. 471-472
Author(s):  
Aida Oulehri ◽  
Sara Elloudi ◽  
Hanane Baybay
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Soft Tissues ◽  
Verrucous Carcinoma ◽  
Previous History ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Complete Surgical Excision ◽  
Safety Margins

Sir, Cutaneous squamous cell carcinoma, a malignant proliferation of the cutaneous epithelium, represents the second most common non-melanoma skin cancer after basal cell carcinoma [1]. Verrucous carcinoma (VC) is a rare, low-grade, well-differentiated squamous cell carcinoma most commonly seen in the mucosa, infrequently reported to occur in the skin, where it is a slow-growing and locally aggressive tumor. It is not uncommon for cutaneous verrucous carcinomas to be mistaken for the more frequent wart (verruca vulgaris) and treated accordingly [2]. The etiopathogenesis of VC is not completely known. One theory mentions the human papillomavirus (HPV) infection; with plantar lesions, the types involved are reported to be 16 and 11 [3]. Histopathological diagnosis is difficult and needs one or more broad and in-depth biopsies. Morbidity results from the local destruction of the skin and soft tissues and, occasionally, from a perineural, muscular, and even bony invasion. Metastasis to regional lymphatic ganglia is rare, found in 5% of cases [4]. VC bears a high risk of local relapse. No matter the treatment employed, the rate of recurrence varies from 30% to 50% and usually is not the result of incomplete surgical interventions. The treatment of choice is complete surgical excision with safety margins [5]. A forty-year-old female patient with no previous history presented herself with a hyperkeratotic lesion on the right foot persistent for two years, which she had been manipulating routinely, which had progressively been increasing in size for the previous year, and which, for the previous three months, had become painful and bleeding. An examination revealed a hyperkeratotic plaque with a hyperpigmented border, hard on palpation, adherent to the deep plane, and with an eroded surface (Fig. 1). Dermoscopy was able to find a papillomatous appearance surrounded by dotted vessels (Fig. 2). This dermoscopic aspect typical of vulgar warts was confusing. Indeed, dermoscopy of the foot wart shows red or black dots in the center of papillomatous structures, which are thrombosed vessels supplying the wart; hence the importance, in our opinion, of the clinical and pathological correlation. For this reason, we performed a skin biopsy; an anatomopathological study found a squamous cell carcinoma of the verrucous type.

scholarly journals SCALED CELL CARCINOMA TYPE VERRUCOUS INFILTRATED – CASE STUDY

2019 ◽  
Vol 7 (4) ◽  
pp. 11-16
Author(s):  
Dr. Xavier Antonio Chan Gómez ◽  
Dr. Jorge Daher Nader ◽  
Bella Vallejo López
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Diagnosis ◽  
Early Complications ◽  
Early Health ◽  
Vulvar Tumor ◽  
Present Case Study

Disorders in patients who develop squamous cell carcinoma can lead to severe conditions. The present case study evidences the advance of this pathology in a patient who goes to the medical services when the problem has advanced. Objective- To describe the case of a patient who underwent surgery to remove a tumor from the vulvar region to prevent it from triggering in severe states. Method - Surgery of a vulvar tumor, performed on a female patient of 62 years. Result- Squamous cell carcinoma, infiltrative verrucous type, with dimensions of 7x6 cm, with an invasion depth of 2.7 mm in the central region    Conclusion- This type of pathology should not be allowed to worsen when it occurs, as it deteriorates the quality of life of patients over the years. If it is detected and treated early, complications can be avoided. In the present case, the histopathological diagnosis was epidermoid carcinoma. It is expected that the information collected will be useful to professionals and that it contributes as an alert to detect early health problems in patients.

Procedures and pitfalls in incisional biopsies of oral squamous cell carcinoma with respect to histopathological diagnosis

2020 ◽  
Vol 66 (12) ◽  
pp. 101035
Author(s):  
Roopa S. Rao ◽  
Kasimsetty Ramakantha Chatura ◽  
Sowmya SV ◽  
Kavitha Prasad ◽  
Surendra Lakshminarayana ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Diagnosis

scholarly journals Primary squamous cell carcinoma of the breast: a rare entity, representation of two cases

2017 ◽  
Vol 4 (8) ◽  
pp. 2848
Author(s):  
Yoshitha Siripurapu ◽  
Bhawna Dev ◽  
Ramya Ramakrishnan ◽  
Sandhya Sundaram
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hormone Receptors ◽  
Final Diagnosis ◽  
Histopathological Diagnosis ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast ◽  
History Of ◽  
Invasive Breast Carcinomas

The aim of this study was to diagnose primary squamous cell carcinoma of the breast with clinical, radiological, pathological correlation. We report two cases of primary squamous cell carcinoma of the breast. Both the patients presented with a palpable lump, with no family history of breast carcinoma. Post-operative histopathological diagnosis was squamous cell carcinoma with immunohistochemistry positive for p63 and negative for hormone receptors. Primary squamous cell carcinoma (SqCC) of the breast is a very rare tumor accounting for less than 0.1% of all invasive breast carcinomas. It is known to be a very aggressive which is a hormone receptor negative and is treatment refractory tumor with poor prognosis. In both our cases, a final diagnosis of SqCC was made after an extensive work up for primary or metastatic disease.

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