Cellular Angiofibroma: A Rare Vulvar Tumor Case Report

Cellular angiofibroma (CA)is a rare benign mesenchymal tumor. In women, it occurs mainly in the vulvovaginal region, with vulvar location in 70% of the cases. Its clinical presentation is nonspecific and similar to several other vulvar tumors of different cellular origins. Thus, its histological and immunohistochemical features allow distinction from other tumors. Cellular angiofibromas have good prognosis, despite some risk of relapse. The authors present the case of a 49-year-old woman with a bulky right vulvar lesion, for which the preoperative diagnosis was a Bartholin cyst, but the histological and immunohistochemical evaluation yielded a CA.

Transcatheter Arterial Chemoembolization Treatment for Vulvar Cancer: A Case Report

Vulvar cancer is a rare malignant tumor occurring in elderly postmenopausal women. At present, surgery is the main treatment for vulvar cancer. Chemotherapy alone has no obvious therapeutic effect as a treatment for vulvar cancer, so it is often combined with radiotherapy or surgery. Selective arterial infusion chemotherapy and embolization is rarely used for the treatment of vulvar cancer. A 63-year-old Tibetan woman underwent superselective arteriography and embolization. On the 7th day after the operation, the vulvar tumor was necrotic and fell off, and a skin defect at the left labia majora appeared. This patient had no other serious complications. Arterial embolization can block the blood supply to a vulvar tumor, has an obvious effect in reducing the tumor, and can even induce tumor necrosis and make the tumor fall off. However, the skin defect after necrosis and abscission does not heal easily, and even carries the risk of local bleeding, which should be paid attention to by the interventionalist and oncologist. The clinical effects of transcatheter arterial embolization for vulvar cancer still need to be studied by interventionalists and oncologists.

Association of a large vulvar tumor in a in a young premenopausal woman with recurrent pseudoangiomatous stromal hyperplasia of the breasts

Pseudoangiomatous stromal hyperplasia is a benign proliferative lesion of the breast tissue that typically affects women in the reproductive age. Pseudoangiomatous stromal hyperplasia usually presents as a localized, painless, firm mass or as a diffuse thickened area of the breast. Rarely, it can arise along the embryonic milk line, up to the anogenital region, where it simulates angiosarcomas. Awareness of this uncommon condition is important in order to avoid unnecessary aggressive excisional surgical procedures. For this purpose, we present a case of nodular pseudoangiomatous stromal hyperplasia arising in the vulva in a patient with recurrent pseudoangiomatous stromal hyperplasia of the breast.

VULVAR TUMOR - CASE REPORT AND LITERATURE REVIEW

The vulvar region is a complex area because it comprises many elements, besides the skin itself. Therefore, it can present a variety of relatively rare tumors that can be classified based on source tissue (epithelial or mesenchymal). Benign epithelial tumors in the connective tissue are not often diagnosed in the vulvar area, which is mostly affected by fibroepithelial polyps.

Leiomyosarcoma: A Rare Tumor of the Vulva

Objective Primary sarcomas of the vulva are very rare malignancies, accounting for 1% to 3% of all gynecologic sarcomas. Leiomyosarcoma is the most common histologic type. They present with nonspecific symptoms, aggressive behavior, and high metastatic potential. Methods A 63-year-old female patient presented with a 6-month history of a slow-growing, painless vulvar mass at the right posterior fourchette. CT scan revealed an asymmetric, heterogeneous vulvar mass extending to the distal vagina, without lymphadenopathy or evidence of distant metastasis. Focal prominence of the uterus suggestive of leiomyoma was also noted, but primary uterine neoplasm with vulvar metastasis could not be excluded. The patient underwent wide local excision of the vulvar mass with hysterectomy and bilateral salpingo-oophorectomy. Results Gross examination of the vulvar specimen showed an ulcerated 2.1-cm solid white mass with irregular borders. Microscopically, the vulvar tumor consisted of a focally infiltrative spindle and pleomorphic neoplastic proliferation with interlacing fascicular pattern and increased mitotic activity up to 25/10 HPF, without necrosis or lymphovascular invasion. The tumor focally extended to resection margins. Immunohistochemically, the neoplastic cells were positive for SMA, ER, and desmin and negative for S-100 and cytokeratin AE1/AE3. These findings, in conjunction with the clinical presentation, were consistent with high-grade primary vulvar leiomyosarcoma. Radiation therapy was subsequently started. Conclusion Primary vulvar leiomyosarcomas are rare and secondary involvement by uterine primary should always be ruled out. In addition, these tumors can be mistaken clinically as benign processes such as Bartholin gland cysts, infectious granuloma, fibroma, or myoma. Hence, it is vital to consider vulvar sarcomas in the differential diagnosis of nonspecific vulvar lesions in order to avoid delay in diagnosis and treatment. The rarity of this diagnosis makes this case worth reporting.

SCALED CELL CARCINOMA TYPE VERRUCOUS INFILTRATED – CASE STUDY

Disorders in patients who develop squamous cell carcinoma can lead to severe conditions. The present case study evidences the advance of this pathology in a patient who goes to the medical services when the problem has advanced. Objective- To describe the case of a patient who underwent surgery to remove a tumor from the vulvar region to prevent it from triggering in severe states. Method - Surgery of a vulvar tumor, performed on a female patient of 62 years. Result- Squamous cell carcinoma, infiltrative verrucous type, with dimensions of 7x6 cm, with an invasion depth of 2.7 mm in the central region Conclusion- This type of pathology should not be allowed to worsen when it occurs, as it deteriorates the quality of life of patients over the years. If it is detected and treated early, complications can be avoided. In the present case, the histopathological diagnosis was epidermoid carcinoma. It is expected that the information collected will be useful to professionals and that it contributes as an alert to detect early health problems in patients.

SCALED CELL CARCINOMA TYPE VERRUCOUS INFILTRATED – CASE STUDY

Disorders in patients who develop squamous cell carcinoma can lead to severe conditions. The present case study evidences the advance of this pathology in a patient who goes to the medical services when the problem has advanced. Objective- To describe the case of a patient who underwent surgery to remove a tumor from the vulvar region to prevent it from triggering in severe states. Method - Surgery of a vulvar tumor, performed on a female patient of 62 years. Result- Squamous cell carcinoma, infiltrative verrucous type, with dimensions of 7x6 cm, with an invasion depth of 2.7 mm in the central region Conclusion- This type of pathology should not be allowed to worsen when it occurs, as it deteriorates the quality of life of patients over the years. If it is detected and treated early, complications can be avoided. In the present case, the histopathological diagnosis was epidermoid carcinoma. It is expected that the information collected will be useful to professionals and that it contributes as an alert to detect early health problems in patients.