Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Monolithic matrix tablets of metformin hydrochloride were formulated as extended release tablets by employing ethyl cellulose polymer and the extended release characterization of the formulated tablets was investigated. Extended release matrix tablets containing 500 mg metformin hydrochloride were developed by changing concentration of drug : polymer (EC) in the ratio of 5:1, 5:2, 5:3 and 5:4 by direct compression. Formulations were optimized based on the acceptable tablet properties invitro and invivo drug release. The resulting formulations produced robust tablets with optimum hardness, weight variation, drug content and low friability. The result of invitro and invivo drug release studies indicated that formulation (drug:polymer =5:3), is the most successful of the study and exhibited constant and extended release of metformin hydrochloride 99-100.5% release at the end of 10 h compared with reference standard. Further, the formulation F3 was subjected to exposure at room and accelerated condition to stability studies. A decrease in release of the drug was observed on increasing polymer ratio at certain level. Before tablet compression, the resulting formulation blends were evaluated for angle of repose, bulk density, % porosity, % compressibility index and drug polymer compatibility study of drug and excipients. The t25, t50 and t90 drug release values was calculated from selected formulation F3 on every month of stability studies and comparision of both room and accelerated condition by statistical t-test, there is no difference between storage temperature. The formulation F3 was showed similar invitro and invivo drug release when compared to marketed sustained release tablet (F5M).

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Preparation of Metformin Hydrochloride Extended Release Matrix Tablets by Direct Compression Method and Its In vitro Evaluation

British Journal of Pharmaceutical Research ◽

10.9734/bjpr/2014/14013 ◽

2014 ◽

Vol 4 (24) ◽

pp. 2679-2693 ◽

Cited By ~ 3

Author(s):

Mohammad Hasan ◽

Md. Hossen ◽

Aumit Roy ◽

Tufikul Islam ◽

Md. Pathan

Keyword(s):

Extended Release ◽

Matrix Tablets ◽

Metformin Hydrochloride ◽

Direct Compression ◽

Compression Method ◽

In Vitro Evaluation

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Metformin Hydrochloride Extended-Release Tablets

10.31003/uspnf_m871_13_01 ◽

2022 ◽

Keyword(s):

Extended Release ◽

Metformin Hydrochloride

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Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets

Pharmaceutics ◽

10.3390/pharmaceutics12020174 ◽

2020 ◽

Vol 12 (2) ◽

pp. 174

Author(s):

Rebeca Simancas-Herbada ◽

Ana Fernández-Carballido ◽

Juan Aparicio-Blanco ◽

Karla Slowing ◽

Jorge Rubio-Retama ◽

...

Keyword(s):

Matrix Tablets ◽

Fickian Diffusion ◽

Metformin Hydrochloride ◽

Oral Toxicity ◽

Crosslinking Degree ◽

Polymer Swelling ◽

Hydrophilic Drugs ◽

Swelling Capacity ◽

The Matrix ◽

Model Drug

The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two different crosslinking degrees that were characterized by FTIR and DSC. Their acute oral toxicity was determined in a mouse model, showing no toxicity at doses up to 10 g/kg. Matrix tablets were prepared using metformin hydrochloride as a model drug and the mechanisms involved in drug release (swelling and/or erosion) were investigated using biorrelevant media. This new hydrogel effectively controlled the release of small and highly hydrophilic molecules as metformin, when formulated in matrix tablets for oral administration. The rate of metformin release from PAMgA matrices was mainly controlled by its diffusion through the gel layer (Fickian diffusion). The swelling capacity and the erosion of the matrix tablets influenced the metformin release rate, that was slower at pH 6.8, where polymer swelling is more intensive, than in gastric medium, where matrix erosion is slightly more rapid. The crosslinking degree of the polymer significantly influenced its swelling capacity in acid pH, where swelling is moderate, but not in intestinal fluid, where swelling is more intense.

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Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

ISRN Pharmaceutics ◽

10.5402/2012/364261 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Amitava Roy ◽

Kalpana Roy ◽

Sarbani Roy ◽

Jyotirmoy Deb ◽

Amitava Ghosh ◽

...

Keyword(s):

Drug Release ◽

Sustained Release ◽

Hydroxypropyl Methylcellulose ◽

Dissolution Kinetics ◽

Matrix Tablets ◽

Metformin Hydrochloride ◽

Wet Granulation ◽

Matrix Tablet ◽

Response Surface Optimization

The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique. In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were X60, X120, T50, T90, n, and b values obtained from dissolution kinetics data. The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism. The drug release was found to reveal zero order kinetics. The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels. There were no significant drug-polymer interactions as revealed by infrared spectra. It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.

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