scholarly journals Laryngotracheal and pulmonary aspergillosis in an adolescent with acute lymphoblastic leukemia: case report

2021 ◽  
Vol 50 ◽  
pp. e20215025
Author(s):  
Gabriela De Martin Silva ◽  
Fábio da Cunha Peixoto Ladeira ◽  
João Batista de Oliveira Andrade ◽  
Scheilla Torres de Oliveira ◽  
Joaquim Caetano de Aguirre
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Pulmonary Aspergillosis

scholarly journals Case Report: Sudden Fatal Hemorrhage in Ulcerative Fungal Laryngotracheitis—A Pediatric Case Report

2022 ◽  
Vol 9 ◽  
Author(s):  
Andrea Porzionato ◽  
Elena Stocco ◽  
Aron Emmi ◽  
Veronica Macchi ◽  
Raffaele De Caro
Keyword(s):  
Risk Factor ◽  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Immunocompromised Patients ◽  
Full Thickness ◽  
Autopsy Case ◽  
Pulmonary Aspergillosis ◽  
Pediatric Case ◽  
Fatal Hemorrhage

In this report, we describe an autopsy case of a child affected by acute lymphoblastic leukemia and opportunistic pulmonary aspergillosis. The patient died because of a full-thickness tracheal wall ulceration with right inferior thyroid artery lesion and sudden hemorrhage, likely ascribable to undiagnosed invasive Aspergillus laryngotracheitis. Aspergillus infection, particularly in immunocompromised patients, should be considered an urgent risk factor to manage as it may lead to sudden fatal events in absence of evident critical symptoms.

Isavuconazole Treatment of Cerebral and Pulmonary Aspergillosis in a Pediatric Patient With Acute Lymphoblastic Leukemia: Case Report and Review of Literature

2019 ◽  
Vol 42 (6) ◽  
pp. e469-e471 ◽  
Author(s):  
Francesco De Leonardis ◽  
Chiara Novielli ◽  
Benedetta Giannico ◽  
Maria Addolorata Mariggiò ◽  
Elio Castagnola ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Pediatric Patient ◽  
Lymphoblastic Leukemia ◽  
Review Of Literature ◽  
Pulmonary Aspergillosis

Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease

2018 ◽  
Vol 25 (8) ◽  
pp. 2027-2030 ◽  
Author(s):  
Jason Chen ◽  
Dat Ngo ◽  
Joseph Rosenthal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Central Nervous System Involvement ◽  
Altered Mental Status ◽  
Intrathecal Chemotherapy ◽  
Speech Impairment ◽  
Central Nervous System Toxicity

A 26-year-old male with a history of pre-B cell acute lymphoblastic leukemia and seizures presented with second relapse of acute lymphoblastic leukemia and central nervous system involvement, 19 years after the initial diagnosis. Over the next two months, the patient received six doses of triple intrathecal chemotherapy (cytarabine, methotrexate, and hydrocortisone), three concurrently with continuous blinatumomab in the second month. Approximately 12 days after blinatumomab initiation, he developed central nervous system toxicity manifesting as speech impairment, altered mental status, incontinence, and diffuse weakness. Blinatumomab was discontinued, and he was started on dexamethasone. Within the next couple of months, his neurologic status recovered, and he was able to perform all of his baseline activities without limitation. Unfortunately, the patient eventually expired after further relapse approximately one year later. To our knowledge, this is the first published case report of severe neurotoxicity in a patient who was given blinatumomab concurrently with intrathecal chemotherapy.

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