Defining genetic changes associated with cutaneous malignant melanoma

2010 ◽  
pp. 33-52
Author(s):  
Mezbah U Faruque ◽  
Jeffrey M Trent
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Malignant Melanoma ◽  
Genetic Changes

Genetics of Cutaneous Malignant Melanoma

1995 ◽  
Vol 2 (5) ◽  
pp. 392-397 ◽  
Author(s):  
Yan A. Su ◽  
Jeffrey M. Trent
Keyword(s):  
Malignant Melanoma ◽  
Tumor Suppressor ◽  
Clinical Significance ◽  
Cutaneous Melanoma ◽  
Genetic Disease ◽  
Tumor Suppressor Genes ◽  
Cutaneous Malignant Melanoma ◽  
Suppressor Genes ◽  
Genetic Changes

An increase in the clinical significance of cutaneous malignant melanoma has paralleled a dramatic increase in the rate of death from this disease. The critical genetic changes associated with the genesis and progression of this disease are only beginning to be identified. This review highlights genetic changes in cutaneous melanoma and discusses the genetics of predisposition, cytogenetics, changes in proto-oncogenes and oncogenes, and evidence for the role of tumor suppressor genes in this malignancy. The viewpoint of this article is that malignant melanoma is a genetic disease.

Cutaneous malignant melanoma in an elderly patient with intermediate junctional epidermolysis bullosa

2021 ◽  
Author(s):  
Yuta Yamashita ◽  
Tomoki Taki ◽  
Takuya Takeichi ◽  
Mao Okumura ◽  
Shoichiro Mori ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Malignant Melanoma ◽  
Epidermolysis Bullosa ◽  
Cutaneous Malignant Melanoma ◽  
Junctional Epidermolysis Bullosa

scholarly journals Association between Oral Contraceptives and cutaneous melanoma: a systematic review and metanalysis

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
I Giacchetta ◽  
M Chiavarini ◽  
G Naldini ◽  
R Fabiani
Keyword(s):  
Systematic Review ◽  
Malignant Melanoma ◽  
Publication Bias ◽  
Oral Contraceptives ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Cutaneous Malignant Melanoma ◽  
Hormonal Factors ◽  
Increased Risk

Abstract Background The probability of developing invasive cutaneous malignant melanoma (CMM) is higher in women than in men up until the age of 49. Several studies investigated the association between hormonal factors and CMM. The aim of this systematic review and meta-analysis is to summarize the evidence on the association between Oral Contraceptives (OC) and the risk of CMM. Methods This review and meta-analysis follow the PRISMA guidelines. A systematic literature search was conducted on Medline and Web of Science until December 2019. Studies were eligible if reported a risk estimate for the association between OC and CMM. Heterogeneity testing was performed using Cochran's Q and I2 statistics. Publication bias was assessed by Egger's test and Begg's test. Meta-analysis was performed using random effect model. Results The results of the pooled analysis of all 32 studies showed no significant association between OC and the risk of CMM (OR 1.02; 95% CI 0.94-1.11; I2=39.32%, p = 0.013). The stratified analyses by study design found no significant association between OC and the risk of CMM neither in the 18 case-control studies (OR 1.02; 95% CI 0.87-1.21; I2=56.91%, p = 0.002) nor in the 14 cohort studies (OR 1.04; 95% CI 0.98-1.11; I2=0.00%, p = 0.557). No significant publication bias could be detected by Egger's test or Begg's test. Conclusions This meta-analysis of available literature suggests no significant association between OC and the risk of developing CMM. Further investigations are needed to evaluate the possible relationship of OC use and other hormonal factors potentially contributing to the increased risk of CMM in women during their reproductive years. Key messages Oral contraceptives (OC) do not significantly contribute to the risk of Cutaneous Malignant Melanoma (CMM). Further studies are needed to investigate the potential role of other hormonal factors in the increased probability of developing CMM in women during their reproductive years.

Lymphatic flow is mostly preserved after sentinel lymph node biopsy in primary cutaneous malignant melanoma

2015 ◽  
Vol 78 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Kenji Yokota ◽  
Masaki Sawada ◽  
Takaaki Matsumoto ◽  
Yoshie Hasegawa ◽  
Michihiro Kono ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Malignant Melanoma ◽  
Lymph Node Biopsy ◽  
Cutaneous Malignant Melanoma ◽  
Primary Cutaneous Malignant Melanoma ◽  
Lymphatic Flow ◽  
Node Biopsy

Cutaneous malignant melanoma

1991 ◽  
Vol 7 (1) ◽  
pp. 26-35
Author(s):  
Patricia E. Lawler
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Malignant Melanoma

Birth outcome in Danish women with cutaneous malignant melanoma

2007 ◽  
Vol 17 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Vivian Langagergaard ◽  
Erzsebet H. Puho ◽  
Timothy L. Lash ◽  
Bente N??rg??rd ◽  
Henrik T. S??rensen
Keyword(s):  
Malignant Melanoma ◽  
Birth Outcome ◽  
Cutaneous Malignant Melanoma
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