Genetic Sequence Semantic and Syntactic Patterns

Personality Genetics

10.31234/osf.io/3rz8y ◽

2018 ◽

Author(s):

Jaime Derringer

Keyword(s):

Cultural Context ◽

Behavior Genetics ◽

Genetic Research ◽

Reliability And Validity ◽

Experimental Manipulation ◽

Sequence Information ◽

Natural Experiments ◽

Genetic Sequence ◽

Form And Function ◽

Causal Pathway

Although correlations between personality and health are consistently observed, often the causal pathway, or even the direction of effect, is unknown. Genes provide an additional node of information which may be included to help clarify the relationship between personality and health. Genetically informative studies, whether focused on family-identified relationships or specific genotypes, provide clear benefits to disentangling causal processes. Genetic measures approach near universal reliability and validity: processes of inheritance are consistent across cultures, geography, and time, such that similar models and instruments may be applied to incredibly diverse populations. Although frequency and intercorrelations differ by ancestry background (Novembre et al., 2008) and cultural context (Tucker-Drob & Bates, 2016) may exert powerful moderating effects, fundamental form and function is consistent across all members of our species, and even many other species. Genetic sequence information is also of course highly temporally stable, and possesses temporal precedence. That is, the literal genetic sequence is lifetime-stable and comes before all other experiences. Human behavior genetic research, like most personality research, faces limitations in terms of causal inferences that may be made in the absence of experimental manipulation. But behavior genetics takes advantage of natural experiments: populations that differ in terms of genetic similarity (either inferred – such as twins – or measured – such as genotyping methods) to begin to unravel the complex influences on individual differences in personality and health outcomes.

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An error-correcting code framework for genetic sequence analysis

Journal of the Franklin Institute ◽

10.1016/j.jfranklin.2003.12.009 ◽

2004 ◽

Vol 341 (1-2) ◽

pp. 89-109 ◽

Cited By ~ 24

Author(s):

Elebeoba E. May ◽

Mladen A. Vouk ◽

Donald L. Bitzer ◽

David I. Rosnick

Keyword(s):

Sequence Analysis ◽

Error Correcting Code ◽

Genetic Sequence ◽

Genetic Sequence Analysis

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perfectphyloR: An R package for reconstructing perfect phylogenies

BMC Bioinformatics ◽

10.1186/s12859-019-3313-4 ◽

2019 ◽

Vol 20 (1) ◽

Author(s):

Charith B. Karunarathna ◽

Jinko Graham

Keyword(s):

Binary Tree ◽

Sequence Data ◽

R Package ◽

Binary Sequences ◽

Ancestral Haplotype ◽

Perfect Phylogeny ◽

Nested Partitions ◽

Genetic Sequence ◽

Insight Into ◽

Rooted Binary Tree

Abstract Background A perfect phylogeny is a rooted binary tree that recursively partitions sequences. The nested partitions of a perfect phylogeny provide insight into the pattern of ancestry of genetic sequence data. For example, sequences may cluster together in a partition indicating that they arise from a common ancestral haplotype. Results We present an R package to reconstruct the local perfect phylogenies underlying a sample of binary sequences. The package enables users to associate the reconstructed partitions with a user-defined partition. We describe and demonstrate the major functionality of the package. Conclusion The package should be of use to researchers seeking insight into the ancestral structure of their sequence data. The reconstructed partitions have many applications, including the mapping of trait-influencing variants.

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Effects of intra-gene fitness interactions on the benefit of sexual recombination

Biochemical Society Transactions ◽

10.1042/bst0340560 ◽

2006 ◽

Vol 34 (4) ◽

pp. 560-561 ◽

Cited By ~ 6

Author(s):

R.A. Watson ◽

D.M. Weinreich ◽

J. Wakeley

Keyword(s):

Nucleotide Sequence ◽

Point Mutation ◽

Sequence Space ◽

Fitness Effect ◽

Epistatic Interactions ◽

Genetic Sequence ◽

High Fitness ◽

Sexual Recombination ◽

Evolutionary Trajectories ◽

Asexual Populations

Whereas spontaneous point mutation operates on nucleotides individually, sexual recombination manipulates the set of nucleotides within an allele as an essentially particulate unit. In principle, these two different scales of variation enable selection to follow fitness gradients in two different spaces: in nucleotide sequence space and allele sequence space respectively. Epistasis for fitness at these two scales, between nucleotides and between genes, may be qualitatively different and may significantly influence the advantage of mutation-based and recombination-based evolutionary trajectories respectively. We examine scenarios where the genetic sequence within a gene strongly influences the fitness effect of a mutation in that gene, whereas epistatic interactions between sites in different genes are weak or absent. We find that, in cases where beneficial alleles of a gene differ from one another at several nucleotide sites, sexual populations can exhibit enormous benefit compared with asexual populations: not only discovering fit genotypes faster than asexual populations, but also discovering high-fitness genotypes that are effectively not evolvable in asexual populations.

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Efficacy and Safety of AZD1222, BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2

Albanian Journal of Trauma and Emergency Surgery ◽

10.32391/ajtes.v5i1.178 ◽

2021 ◽

Vol 5 (1) ◽

pp. 791-796

Author(s):

Ilir Alimehmeti

Keyword(s):

Clinical Trials ◽

Diagnostic Tests ◽

Web Of Science ◽

Rapid Development ◽

Phase Iii ◽

Efficacy And Safety ◽

Vaccine Candidates ◽

Genetic Sequence ◽

Phase Iii Clinical Trials ◽

Clinical Trial Results

SARS-CoV-2, the beta coronavirus causing COVID-19, was isolated and categorizes as a novel one on January 7th, 2020 in China.[1] To date, official reports depict that SARS-CoV-2 has already infected 88.828.387 persons and caused 1.926.625 deaths worldwide.[2] On January 12th, 2020, China officials made public its genetic sequence, thus paving the way towards the research and development of diagnostic tests and vaccines. With regard to vaccination, e large number of clinical trials were designed and are currently undergoing, of which 189 are listed in ClinicalTrials.gov. [3] However, up to date, only three vaccines have published their respective phase III clinical trial results in peer-reviewed medical journals. [4-6] Vaccines are needed to reduce the morbidity and mortality associated with Covid-19, and multiple vaccine platforms as AZD1222 (AstraZeneca) [4], BNT162b2 (Pfizer/BioNTech) [5] and mRNA-1273 (Moderna) have been involved in the rapid development of vaccine candidates. Methodology: In this review, PubMed, Embase, Web of Science, Scopus, medRxiv, and bioRxiv were systematically scrutinized for peer-reviewed and preprint articles on phase III clinical trials of vaccines against SARS-CoV-2. In total, only three peer-reviewed papers fulfilling the search criteria were identified. Conclusions; All vaccine candidates should publish in peer-reviewed journals their efficacy and safety well before requesting approval to the national or international authorities…

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