Abstract
Introduction: Coronavirus disease (COVID-19) is a global infectious disease with a large burden of illness and high healthcare costs.Objectives: This study aimed to compare clinical features among adult COVID-19 patients in different age groups.Methods: Laboratory-confirmed adult COVID-19 infection cases between Dec 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups: age༜30, 30–40, 40–50, 50–65, ≥ 65 y (elderly). Age, sex, history of chronic disease and epidemiology, symptoms, laboratory tests, and outcomes were compared among different age groups. Binary logistic regression analysis was conducted to evaluate associated factors for severe or critical type.Results: We studied 299 cases. Median (IQR) age was 44 (34,54) and 158 (53%) were male. Percent of bilateral involvement on chest radiographs was increased significantly with older age (p = 0.005). 53.3% of 30–40 years, 50% of 40–50 years, 36.6% of ༜30 years and 36.2% of 50–60 years were imported case, none of the elderly were imported case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups (p < 0.001). Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35% in patients with age༜30, 30–40, 40–50, 50–65, ≥ 65 (p < 0.001), respectively. At this point, ICU admission rate, ARDS and shock rate and on medical treatment rate was increased especially in patients ≥ 65 years. 285 patients (95.3%) were cured and discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.67%) deaths; these occurred among persons ≥ 65 y (p < 0.001). Old age, high HR on admission, high respiratory rate on admission, and history of chronic heart disease were independently associated with severe or critical .Conclusions: Proportion of severe or critical type increased with old age groups. Adults with old age and high HR, R rate in admission and history of chronic heart disease were associated with severe or critical type in COVID-19.