scholarly journals Cerclage outcomes in singleton pregnancies at risk for preterm birth following assisted reproductive treatments

2021 ◽  
Vol 3 (3) ◽  
pp. 78-82
Author(s):  
Gülnaz Şahin ◽  
Ferruh Acet ◽  
Ege Nazan Tavmergen Goker ◽  
Erol Tavmergen
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Gestational Age ◽  
Cervical Insufficiency ◽  
Special Group ◽  
Cervical Cerclage ◽  
Unicornuate Uterus ◽  
Gestational Age At Delivery ◽  
History Of ◽  
Singleton Pregnancies

Objective: We aimed to evaluate the obstetric and neonatal outcomes of singleton pregnancies at risk for preterm birth (PTB) following assisted reproductive treatments and underwent cervical cerclage placement. Material and methods: A total of 42 women with singleton pregnancies following ART who underwent cerclage between 2009-2021 were included in this retrospective study.  Indications of the cerclage procedure, gestational age at cerclage placement and delivery, neonatal birthweight, and requirement for admission to the neonatal unit of newborns were evaluated. Results: Of those cerclage placement performed in women with a history of second-trimester loss (19%), women with suspected cervical insufficiency according to pre-pregnancy evaluation (52.4%), women with the unicornuate uterus (4.8%), women with cervical shortening/or suspicious changes on ultrasonography (11.9%), and women with detection of cervical dilatation/shortening beyond 20 weeks of gestation (11.9%). Of the total group, 7.1% resulted in late miscarriages, while the remaining 92.9% ended with a live birth with mean gestational age at delivery of 37.0±2.5 weeks. Of those live births, 92.3% (36/39) delivered at >34 weeks and %74.4 (29/39) delivered at term. Except one neonatal death due to extremely PTB at 26th weeks, all infants were discharged from the hospital with well condition. Conclusion: ART pregnancies are evaluated as a special group as having a higher PTB risk at baseline. Cerclage may be considered in broader indications for suspected cervical insufficiency in these pregnancies. There is need for further studies on the effectiveness of cerclage in these ART pregnancies with suspected cervical insufficiency based on different criterions used.

scholarly journals Cervical Cerclage: Does the Location of the Suture Placement Make a Difference?

2017 ◽  
Vol 34 (1) ◽  
pp. 16-19
Author(s):  
Boris Petrikovsky ◽  
Michael Terrani ◽  
Steven Swancoat ◽  
Alison Dillon
Keyword(s):  
Preterm Birth ◽  
Pregnancy Outcome ◽  
Gestational Age ◽  
Cervical Insufficiency ◽  
Middle Portion ◽  
Cervical Cerclage ◽  
The Third ◽  
Gestational Age At Delivery ◽  
Suture Placement

Introduction: The aim of cervical cerclage is to prevent or treat cervical insufficiency. The goal of the study was to investigate the correlation between the location of the cerclage suture within the cervix and its efficacy in preventing preterm birth. Materials and methods: Sixty-seven images of the cervix performed within two weeks of cerclage placement were extracted from the sonographic database and collected. The location of cerclage was divided into three categories: within the vicinity of the internal os, in the middle portion of the cervix, and in the vicinity of the external os. Gestational age at delivery was analyzed in the groups. Results: In 26 patients, the suture was identified in the vicinity of the internal os. Most of these patients delivered between 34 and 41 weeks of pregnancy. In 29 patients, the suture was located in the middle portion of the cervix. Most of these patients delivered between 33 and 40 weeks of pregnancy. The third group consisted of 12 patients, in whom cervical cerclages were detected in the lower third of the cervix in the vicinity of external os. Five of the 12 patients delivered prior to 30 weeks of pregnancy; the rest delivered between 30 and 34 weeks. Conclusion: Our experience links the sonographically detected cerclage location with pregnancy outcome.

scholarly journals C-STICH: Cerclage Suture Type for an Insufficient Cervix and its Effect on Health Outcomes. A Multicentre Randomised Controlled Trial.

2021 ◽  
Author(s):  
Fidan Israfil-Bayli ◽  
Victoria Ann Hodgetts Morton ◽  
Catherine A Hewitt ◽  
Andrew K Ewer ◽  
Jim Grey ◽  
...  
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Informed Consent ◽  
High Risk ◽  
Perinatal Mortality ◽  
Controlled Trial ◽  
Core Outcome Set ◽  
Cervical Cerclage ◽  
History Of ◽  
Randomised Controlled

Abstract Background: Preterm birth is associated with significant mortality and morbidity for mothers and babies. Women are identified as high risk for preterm birth based on either previous medical/pregnancy history or on ultrasound assessment of the cervix. Women identified as high risk can be offered a cervical cerclage (a purse string stitch) around the cervix (neck of the womb) to reduce the risk of preterm birth. In women who have a cervical cerclage the procedure can be performed using either a monofilament (single-stranded) or braided (woven) suture material. Both suture materials are routinely used for cervical cerclage and there is uncertainty as to which is superior. Methods: A multicentre, open, randomised controlled superiority trial of 2050 women presenting at obstetric units, deemed to be at risk of preterm birth and already scheduled to have a cervical cerclage as part of their standard care. Inclusion criteria include singleton pregnancies and an indication for cervical cerclage for either: a history of three or more previous mid trimester losses or premature births (≤ 28 weeks), insertion of cervical sutures in previous pregnancies, a history of mid trimester loss or premature birth with a (current) shortened (≤ 25 mm) cervix, or women whom clinicians deem to be at risk of preterm birth either by history or the results of an ultrasound scan. Exclusion criteria include women; who have taken part in C-STICH previously, aged less than 18 years old at the time of presentation, requiring a rescue cerclage, who are unwilling or unable to give informed consent and in whom a cerclage will be placed by any route other than vaginally (e.g. via an abdominal route). Following informed consent, women are randomised on a 1:1 basis to either monofilament or braided suture, by minimisation. The primary outcome is pregnancy loss (miscarriage and perinatal mortality, including any stillbirth or neonatal death in the first week of life) and secondary outcomes include the core outcome set for preterm birth trials.Discussion: Optimising established interventions to prevent preterm birth is important in reducing perinatal mortality rates.Trial registration: ISRCTN 15373349 registered before recruitment 03/12/2014 prior to first recruit.

Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes

2016 ◽  
Vol 44 (5) ◽  
Author(s):  
Joohee Choi ◽  
Jeong Woo Park ◽  
Byoung Jae Kim ◽  
Ye-Jin Choi ◽  
Jong Hee Hwang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Preterm Labor ◽  
Cervical Insufficiency ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Histologic Chorioamnionitis ◽  
Gestational Age At Delivery ◽  
The Difference

AbstractTo compare the frequency of histologic chorioamnionitis and funisitis among women experiencing preterm labor, preterm premature rupture of membranes (PROM) and cervical insufficiency.This retrospective cohort study included singleton pregnant women who delivered at ≤36 weeks of gestation. The patients with preterm birth were subdivided into preterm labor (n=117), preterm PROM (n=153), and cervical insufficiency (n=20). All placentas were examined for pathology, according to the criteria of1) Histologic chorioamnionitis was diagnosed in 48.7% (57/117) of cases with preterm labor, 47.4% (73/153) with preterm PROM, and 75.0% (15/20) with cervical insufficiency. Funisitis was detected in 11.1% (13/117) of cases with preterm labor, 15.7% (24/153) with preterm PROM, and 40.0% (8/20) with cervical insufficiency. 2) Frequency of histologic chorioamnionitis was higher in cases with cervical insufficiency compared to preterm PROM. Frequency of funisitis was higher in cases with cervical insufficiency compared to both preterm labor and preterm PROM (P<0.05). The difference in frequency of funisitis remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis. 3) Frequency of grade 2 funisitis was higher in cases with cervical insufficiency (35.0%, 7/20) compared to both preterm labor (6.8%, 8/117) and preterm PROM (9.8%, 15/153) (P=0.001). And the difference remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis.: The highest frequency of funisitis was observed in cervical insufficiency among cases with spontaneous preterm birth.

scholarly journals C-STICH: Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes—a multicentre randomised controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Fidan Israfil-Bayli ◽  
Victoria Hodgetts Morton ◽  
Catherine A. Hewitt ◽  
Andrew K. Ewer ◽  
Jim Gray ◽  
...  
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Informed Consent ◽  
High Risk ◽  
Perinatal Mortality ◽  
Controlled Trial ◽  
Core Outcome Set ◽  
Cervical Cerclage ◽  
History Of ◽  
Randomised Controlled

Abstract Background Preterm birth is associated with significant mortality and morbidity for mothers and babies. Women are identified as high risk for preterm birth based on either previous medical/pregnancy history or on ultrasound assessment of the cervix. Women identified as high risk can be offered a cervical cerclage (a purse string stitch) around the cervix (neck of the womb) to reduce the risk of preterm birth. In women who have a cervical cerclage, the procedure can be performed using either a monofilament (single-stranded) or braided (woven) suture material. Both suture materials are routinely used for cervical cerclage and there is uncertainty as to which is superior. Methods A multicentre, open, randomised controlled superiority trial of 2050 women presenting at obstetric units, deemed to be at risk of preterm birth and already scheduled to have a cervical cerclage as part of their standard care. Inclusion criteria include singleton pregnancies and an indication for cervical cerclage for either a history of three or more previous mid-trimester losses or premature births (≤ 28 weeks), insertion of cervical sutures in previous pregnancies, a history of mid trimester loss or premature birth with a (current) shortened (≤ 25 mm) cervix, or women whom clinicians deem to be at risk of preterm birth either by history or the results of an ultrasound scan. Exclusion criteria include women who have taken part in C-STICH previously, are aged less than 18 years old at the time of presentation, require a rescue cerclage, and are unwilling or unable to give informed consent and in whom a cerclage will be placed by any route other than vaginally (e.g. via an abdominal route). Following informed consent, women are randomised on a 1:1 basis to either monofilament or braided suture, by minimisation. The primary outcome is pregnancy loss (miscarriage and perinatal mortality, including any stillbirth or neonatal death in the first week of life), and secondary outcomes include the core outcome set for preterm birth trials. Discussion Optimising established interventions to prevent preterm birth is important in reducing perinatal mortality rates. Trial registration ISRCTN 15373349. Registered before recruitment on 03 December 2014 prior to first recruit.

755: Does mid-trimester Nugent score or vaginal pH predict gestational age at delivery in women at risk for preterm birth?

2008 ◽  
Vol 199 (6) ◽  
pp. S215 ◽  
Author(s):  
Dana Figueroa ◽  
Melissa Mancuso ◽  
Merri Maddox Paden ◽  
Jeff Szychowski ◽  
John Owen
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Gestational Age ◽  
Nugent Score ◽  
Vaginal Ph ◽  
Gestational Age At Delivery

scholarly journals Measurement of the uterocervical angle for the prediction of preterm birth in symptomatic women

2021 ◽  
Author(s):  
Philipp Wagner ◽  
Jana Schlechtendahl ◽  
Markus Hoopmann ◽  
Natalia Prodan ◽  
Harald Abele ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Cervical Length ◽  
University Hospital ◽  
Second Line ◽  
Uterine Contractions ◽  
Gestational Age At Delivery ◽  
The University ◽  
Time Of Presentation ◽  
Singleton Pregnancies

Abstract Purpose To examine if the uterocervical angle (UCA) can be used to predict preterm delivery in women with painful and regular uterine contractions and a cervical length of 25 mm or less. Methods Retrospective study at the perinatal unit of the University Hospital of Tuebingen, Germany. Women with singleton gestation and preterm contractions between 24 + 0 and 33 + 6 weeks’ gestation were included. For the UCA measurement, a line is placed from the internal os to the external os irrespective of whether the cervix is straight or curved. A second line is drawn to delineate the lower uterine segment. The angle between the two lines is the UCA measurement. The measurements were taken on stored images from our database. Results The study consisted of 213 singleton pregnancies. At the time of UCA measurement, median maternal and gestational age was 31.4 years and 29.7 weeks’ gestation. Median gestational age at delivery was 35.3 weeks and the corresponding birth weight 2480 g, respectively. The UCA measurement in women who delivered within 2 days, between 3–7 days and after 7 days was not helpful to distinguish between these three groups [median UCA measurements: 108.5°, 108.0° and 107.3° (Kruskal–Wallis test p = 0.576)]. Uni- and multivariate logistic multiple regression analysis demonstrated that the delivery within 2 days was only dependent on the gestational age and the cervical length at the time of presentation. Conclusion The measurement of UCA is not useful in predicting preterm birth in the subsequent 7 days after an episode of preterm contractions.

Does midtrimester Nugent score or high vaginal pH predict gestational age at delivery in women at risk for recurrent preterm birth?

2011 ◽  
Vol 204 (1) ◽  
pp. 46.e1-46.e4 ◽  
Author(s):  
Dana Figueroa ◽  
Melissa S. Mancuso ◽  
Jeff M. Szychowski ◽  
Merri Maddox Paden ◽  
John Owen
Keyword(s):  
At Risk ◽  
Preterm Birth ◽  
Gestational Age ◽  
Nugent Score ◽  
Vaginal Ph ◽  
Gestational Age At Delivery

scholarly journals Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emma V. Preston ◽  
Victoria Fruh ◽  
Marlee R. Quinn ◽  
Michele R. Hacker ◽  
Blair J. Wylie ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Black Women ◽  
Pilot Study ◽  
Gestational Age ◽  
Endocrine Disrupting Chemical ◽  
Product Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
Gestational Age At Delivery

Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

scholarly journals Pregnancy Outcome after Cerclage for Cervical Incompetence at a Private Hospital of Dhaka

2017 ◽  
Vol 12 (2) ◽  
pp. 78-81
Author(s):  
Shafeya Khanam ◽  
Maliha Rashid ◽  
Ayesha Siddika Purobi ◽  
Zebunnessa Parvin ◽  
Sanjoy Kumar Das ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Fetal Loss ◽  
Cervical Dilatation ◽  
Cervical Insufficiency ◽  
Miscarriage Rate ◽  
Cervical Cerclage ◽  
Cervical Incompetence ◽  
Obstetric Population

Miscarriage, particularly recurrent mid-trimester miscarriage is a distressful condition. This form of miscarriage and preterm birth appear to have some etiologies. An important etiology is cervical incompetence that describes a disorder in which painless cervical dilatation leads to recurrent second trimester pregnancy losses. Every year more than 10 million preterm birth occurs and more than 1 million baby die from this common complication of pregnancy. The incidence of true cervical insufficiency is estimated at less than 1% of the obstetric population. In the index pregnancy, findings indicative of possible cervical insufficiency include cervical funneling, cervical shortening, and overt cervical dilatation. The main objective of the study was to explore the benefit from cervical cerclage in pregnant women with cervical incompetence. This is a retrospective observational study conducted over a period of twelve months. All cases delivered in Central Hospital were assisted by consultant obstetricians, in which 16(61.5%) out of 26 cases were delivered by caesarean section. Miscarriage rate was 11.53%. Out of the caesarean deliveries 2(12.5%) were at term and 14(87.5%) were at preterm. In this study 3(21.42%) babies born at 32nd and 33rd weeks, 6(42.85%) at 34th week and 2(14.28%) were at 35th week. There was no fetal loss. Extreme low birth weight was only one, 7(43.75%) of the babies had normal body weight for the area of study, 8 babies (50%) had low birth weight. The cervical cerclage procedure therefore should be available more widely to benefit those patients with proven or strongly suspected cervical incompetence.Faridpur Med. Coll. J. Jul 2017;12(2): 78-81

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