scholarly journals Assessment of Foot Posture and Related Factors in Patients With Knee Osteoarthritis

Author(s):  
Mazlum Serdar AKALTUN ◽  
Burhan Fatih KOÇYİĞİT
2014 ◽  
Vol 8 (1) ◽  
pp. 96-99 ◽  
Author(s):  
Abourazzak F.E ◽  
Kadi N ◽  
Azzouzi H ◽  
Lazrak F ◽  
Najdi A ◽  
...  

Objectives : To compare foot posture in people with and without medial compartment knee osteoarthritis (OA), and to assess association between its abnormalities and medial compartment knee OA. Methods : We compared the foot posture of patients with clinically and radiographically-confirmed medial compartment knee OA and asymptomatic healthy controls using the foot posture index (FPI), navicular height, and the medial arch. Results : We included 100 patients and 80 asymptomatic controls. The mean age of patients was 59 ± 7 (44-76) years and 48 ± 9 (28-60) years in the control (p=0.06). Patients group have more pronated foot for FPI (1.50 ± 2.68 vs 0.72 ± 2.63; p=0.05), more flat foot (42% vs 22%; p=0.03), and less pes cavus than the control group (58% vs 77%; p=0.004). However, there was no significant difference between the groups in the navicular height (3.90 ± 0.85 cm vs 4.00 ± 0.76 cm; p=0.41). In multivariate statistical analysis, after adjusting for age and body mass index, pronated foot in FPI (OR=1.22, 95%IC= [1.06-1.40], p=0.005), and pes cavus (OR=0.32, 95%IC= [0.11-0.93], p=0.03) had a significant correlation with the knee osteoarthritis. Conclusion : Pronated foot posture and flat foot are significantly associated with medial compartment knee osteoarthritis.


2017 ◽  
Vol 25 ◽  
pp. S131-S132 ◽  
Author(s):  
E. Anzai ◽  
K. Yamashita ◽  
Y. Matsunaga ◽  
M. Sato ◽  
H.B. Menz ◽  
...  

2020 ◽  
Author(s):  
Yong Sun ◽  
Changde Wang ◽  
Chunzhu Gong

Abstract Purpose: To evaluate the repairing effects of glucosamine sulfate combined with etoricoxib on articular cartilages of patients with knee osteoarthritis (KOA). Methods: A total of 106 KOA patients were randomly divided into control (n=40) and experimental groups (n=66), and treated with etoricoxib alone and glucosamine sulfate plus etoricoxib respectively. Changes in WOMAC score and clinical efficacy were observed. The synovial fluid was extracted. Bone metabolism indices, growth factors, inflammatory factors, matrix metalloproteinases (MMPs) and NO-induced apoptosis-related factors were measured by ELISA. JNK and Wnt5a mRNA levels were determined using RT-PCR. Results: After treatment, the total WOMAC scores of both groups significantly declined (P<0.05), being lower in experimental group. The total effective rate of experimental group was higher (P<0.05). BGP and OPG levels rose, especially in experimental group (P<0.05). CTX-II, COMP and RANKL levels decreased, particularly in experimental group (P<0.05). TGF-β, IGF-1 and FGF-2 levels increased, especially in experimental group (P<0.05). Both groups, particularly experimental group, had decreased levels of IL-1β, IL-17, IL-18, TNF-α, MMP-3, MMP-9 and MMP-13 (P<0.05). JNK and Wnt5a mRNA levels of both groups dropped, which were lower in experimental group (P<0.05). NO and LPO levels reduced, being lower in experimental group. SOD level rose, especially in experimental group (P<0.05). Conclusion: Glucosamine sulfate plus etoricoxib can repair the articular cartilages of KOA patients. Probably, JNK and Wnt5a are down-regulated to inhibit the secretion of MMPs through lowering the levels of inflammatory factors, thereby delaying cartilage matrix degradation. NO-induced chondrocyte apoptosis may be suppressed via the SOD pathway.


2020 ◽  
Author(s):  
Yong Sun ◽  
Changde Wang ◽  
Chunzhu Gong

Abstract Purpose: To evaluate the repairing effects of glucosamine sulfate combined with etoricoxib on articular cartilages of patients with knee osteoarthritis (KOA). Methods: A total of 106 KOA patients were randomly divided into control (n=40) and experimental groups (n=66), and treated with etoricoxib alone and glucosamine sulfate plus etoricoxib respectively. Changes in WOMAC score and clinical efficacy were observed. The synovial fluid was extracted. Bone metabolism indices, growth factors, inflammatory factors, matrix metalloproteinases (MMPs) and NO-induced apoptosis-related factors were measured by ELISA. JNK and Wnt5a mRNA levels were determined using RT-PCR. Results: After treatment, the total WOMAC scores of both groups significantly declined (P<0.05), being lower in experimental group. The total effective rate of experimental group was higher (P<0.05). BGP and OPG levels rose, especially in experimental group (P<0.05). CTX-II, COMP and RANKL levels decreased, particularly in experimental group (P<0.05). TGF-β, IGF-1 and FGF-2 levels increased, especially in experimental group (P<0.05). Both groups, particularly experimental group, had decreased levels of IL-1β, IL-17, IL-18, TNF-α, MMP-3, MMP-9 and MMP-13 (P<0.05). JNK and Wnt5a mRNA levels of both groups dropped, which were lower in experimental group (P<0.05). NO and LPO levels reduced, being lower in experimental group. SOD level rose, especially in experimental group (P<0.05). Conclusion: Glucosamine sulfate plus etoricoxib can repair the articular cartilages of KOA patients. Probably, JNK and Wnt5a are down-regulated to inhibit the secretion of MMPs through lowering the levels of inflammatory factors, thereby delaying cartilage matrix degradation. NO-induced chondrocyte apoptosis may be suppressed via the SOD pathway.


2018 ◽  
Vol 86 (6) ◽  
pp. 1111-1117
Author(s):  
AALAA M. SWEELAM, M.Sc.; SALWA F. ABD EL-MAGEED, Ph.D. ◽  
EBTESSAM F. GOMAA, Ph.D.; AHMAD H. AZZAM, M.D.

Author(s):  
Leni Kopen ◽  
Angela BM. Tulaar ◽  
Nyoman Murdana

Introduction: Alteration of foot posture may influence the knee loading, particularly in medial compartment. The purpose of this study was to find the relation of foot postures with clinical finding in medial knee osteoarthritis (KOA).Methods: Subjects with medial KOA who met inclusion criteria were recruited consecutively, in Nursing home on August to October 2018. The foot posture has determined by Foot Posture Index (FPI). The severity of KOA has measured by Kelgreen-Lawrence (KL) grading system, and pain level using numeric rating score (NRS).Results: There were 37 subjects consisted of male and female with normal foot subsequently 17(8.5%) and 3(15%), male and female with abnormal food subsequently 3(15%) and 1(16%). There were 12 (32.43%) of pronated foot, 5 (13.51%) of supinated foot, and 20 (54.06%) of normal foot subjects. The subjects with abnormal foot posture have severe medial KOA (p<0.001), while the pain sensation similar between groups (p=0.321, p=0.688).Conclusion: There was a correlation between foot posture and the severity of medial KOA.Keywords: Foot posture, Knee osteoarthritis, Foot posture index, Numeric rating score


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