scholarly journals Theoretical methods for measuring chemo-physical properties of nucleic acids during the oxidation of DNA and the incidence of cancer

2020 ◽  
Vol 11 (29) ◽  
pp. 428-446
Author(s):  
Mehdi Imanzadeh ◽  
Karim Zare ◽  
Majid Monajjemi ◽  
Ali Shamel
Keyword(s):  
Nucleic Acids ◽  
Physical Properties ◽  
Chain Structure ◽  
Natural State ◽  
Natural Form ◽  
Theoretical Methods ◽  
Dna Base ◽  
Group Oxygen Atom ◽  
Spatial Parameters ◽  
Guanine Base

The purpose of this papers is to investigate theoretical methods to measure the chemo-physical properties of nucleic acids during DNA radicalization and cancer incidence. For this purpose, structures consisting of DNA nucleotides were considered and all structures were optimized using DFT at the CAM-B3LYP / 6-31G level and spatial parameters such as bond length, HOMO and LUMO orbitals, and thermodynamic parameters were obtained, as well as NMR spectroscopy. The results showed that the guanine base had better conditions for oxidation compared to other bases. Also in the NMR calculations using the GIAO method we were able to examine the single and double chain structure in different states when it is natural and abnormal. Therefore, in this work, we try to find a normal relationship between chemical displacement and the rate of natural state DNA aberration, by studying the comparison of isotropic and anisotropic parameters with respect to DNA bases such as adenine, guanine, cytosine, thymine. It was concluded that the skewness (η) is between (0.1) and the skewness is between (1-1), which can be correlated with the abnormalities of the DNA base from the normal to abnormal state. It was also found that the phosphate group oxygen atom in the abnormal form showed most of the changes in these parameters compared to the natural form.

scholarly journals Effect of waste wax and chain structure on the mechanical and physical properties of polyethylene

2015 ◽  
Vol 8 (3) ◽  
pp. 388-399 ◽  
Author(s):  
M.A. AlMaadeed ◽  
Sami Labidi ◽  
Igor Krupa ◽  
Mabrouk Ouederni
Keyword(s):  
Physical Properties ◽  
Chain Structure ◽  
Mechanical And Physical Properties

scholarly journals Guanine base stacking in G-quadruplex nucleic acids

2012 ◽  
Vol 41 (3) ◽  
pp. 2034-2046 ◽  
Author(s):  
Christopher Jacques Lech ◽  
Brahim Heddi ◽  
Anh Tuân Phan
Keyword(s):  
Nucleic Acids ◽  
Base Stacking ◽  
G Quadruplex ◽  
Guanine Base

A Facile Synthesis and Physical Properties of Nano-Sized Dendritic α,ε-Poly(L-lysine)s for the Delivery of Nucleic Acids

2006 ◽  
Vol 6 (11) ◽  
pp. 3532-3538 ◽  
Author(s):  
Khee Dong Eom ◽  
Jin Sook Kim ◽  
Sun Mi Park ◽  
Myong Soo Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Physical Properties ◽  
Facile Synthesis

ChemInform Abstract: Why Pentose- and Not Hexose-Nucleic Acids. Part 3. Oligo(2′,3′-dideoxy- β-D-glucopyranosyl)nucleotides. (“Homo-DNA”): Base-Pairing Properties.

ChemInform ◽  
2010 ◽  
Vol 24 (25) ◽  
pp. no-no
Author(s):  
J. HUNZIKER ◽  
H.-J. ROTH ◽  
M. BOEHRINGER ◽  
A. GIGER ◽  
U. DIEDERICHSEN ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Base Pairing ◽  
Dna Base

Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties

2003 ◽  
Vol 10 (3-4) ◽  
pp. 237-253 ◽  
Author(s):  
Jesper Wengel ◽  
Michael Petersen ◽  
Miriam Frieden ◽  
Troels Koch
Keyword(s):  
Nucleic Acids ◽  
Physical Properties ◽  
Design Synthesis ◽  
Locked Nucleic Acids ◽  
Lna Design

scholarly journals Change of granulometric composition of drained soils of Male Polissia in the context of development of degradation processes

2018 ◽  
pp. 42-52
Author(s):  
Volodymyr Haskevych
Keyword(s):  
Physical Properties ◽  
Granulometric Composition ◽  
Water Regime ◽  
Sandy Loam ◽  
Arable Land ◽  
Clay Content ◽  
Natural State ◽  
Physical Clay ◽  
Groundwater Levels ◽  
Degradation Processes

Sod-podzolic (Albenuvisoils Gleyic), meadow (Gleyic Chernic Phaeozems) and sod (Arenosols) soils are typical for Male Polissia. In the natural state, these soils are waterlogged, characterized by unsatisfactory physical properties, unsuitable for agricultural use. After the drainage reclamation, the soils are intensively used as arable land, pastures, and hayfields. The drainage has led to a significant decrease in groundwater levels, increased the washing water regime, intensified the processes of lessivage, which affected the physical properties of soils, in particular, granulometric composition. In the reclaimed areas, aridification and deflationary processes intensified. In deflated sod-podzolic soils, the relief of granulometric composition has been reducing due to decrease in the content of sludge and fine dust in the arable horizons. Granulometric composition of soils undergoes more significant transformations as a result of the intensification of flushing water regime after drainage. The content of physical clay in the arable horizon of sod-podzolic fixed- sandy soils decreased by 1.63 %, and of the sandy loam soils – by 5.30–6.20 %. In the humus-accumulating arable horizon of meadow soils, the physical clay content decreased by 2.40–1.60 %, that of sod soils – by 1.27–6.39 %. Washing off with drainage waters of small granulometric fractions results in an increase in the content of sand fractions and facilitates the granulometric composition of soils, changes in soil gradation at the level of variety. Decrease in the content of physical clay causes deterioration of physical, physical-and-chemical, agronomic properties of soils, and therefore causes the development of degradation processes: non-structural, deflation, dehumification, degradation of water and air and nutrient regimes, aridification. This gave rise to the idea of referring to the granulometric composition facilitation of drained soils as “granulometric degradation” and classifying it as physical degradation of soils. Key words: Male Polissia, drainage reclamation, soils, granulometric composition, physical clay, granulometric degradation.

scholarly journals Substitution of aggregates by waste foundry sand: effects on physical properties of mortars

2021 ◽  
Vol 71 (343) ◽  
pp. e251
Author(s):  
B.A. Feijoo ◽  
J.I. Tobón ◽  
O.J. Restrepo-Baena
Keyword(s):  
Compressive Strength ◽  
Physical Properties ◽  
Control Sample ◽  
Natural State ◽  
Capillary Absorption ◽  
Foundry Sand ◽  
Physical Behavior ◽  
Thermally Activated ◽  
Heat Treated ◽  
Waste Foundry Sand

The substitution of the normalized aggregate by residual foundry sand (WFS) was studied on the physical properties of mortars by means of resistance to compression and capillary absorption tests. The aggregate was replaced by WFS in its natural state (WFS), washed residual foundry sand (WFSW) and heat treated residual foundry sand (WFST). The WFS had a percentage of bentonite, which was sought to be thermally activated. It was found that the physical behavior of the mortars containing WFS and WFSW was similar to that of the control sample. The clay recovered from the sand washing was evaluated for its pozzolanic potential, it was found that, with the thermal treatment, the montmorillonite acquires pozzolanic behavior. Mortars with WFST presented a drop in compressive strength. The pozzolanic effect achieved in the clay was not reflected in the compressive strength of the mortars with WFST.

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