scholarly journals A Critical Review on Avipathi Choorna- A Unique Formulation for Peptic Ulcer Disease

2021 ◽  
pp. 80-85
Author(s):  
Subha K Nampoothiri ◽  
A Shahul Hameed
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Chemical Constituent ◽  
Duodenal Mucosa ◽  
Pharmacological Properties ◽  
Tissue Layer ◽  
Ulcer Disease ◽  
Stomach Acid ◽  
Inflamed Tissue

Peptic-ulcer-disease is the ulceration of gasrtric or duodenal mucosa due to the digestive action of pepsin and stomach acid. Gastritis, gastric ulcer and duodenal ulcer are included under this. It can be correlated with the condition Parinamasoola mentioned in Ayurveda. Avipathichoornam is a famous Ayurvedic formulation, mentioned in the texts Ashtanga Hridaya and Sahasrayoga. Avipathi choorna exerts its effect in Peptic ulcer disease probably through Deepana, Pachana and Saraka actions by virtue of the pharmacological properties of the ingredients with which the vitiated Pitta can get normalized. It can be deducted that Avipathi choorna probably neutralize the excess acid secretion in the gastrointestinal tract and maintain a healthy pH. The formulation also probably acts by the anti inflammatory property of most of the ingredients which can help pacify the inflamed tissue layer of the gut. The aim of this paper is to demonstrate mode of action of Avipathi choorna in peptic ulcer disease by critically analyzing the pharmacological properties as well as chemical constituent of the ingredients.

Clinical neurological manifestations in patients suffering from peptic ulcer disease in the acute phase and in remission

2021 ◽  
Author(s):  
O. V. Demydas
Keyword(s):  
Duodenal Ulcer ◽  
Nervous System ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Peripheral Nervous System ◽  
Acute Phase ◽  
Neurological Examination ◽  
Acute Stage ◽  
Neurological Manifestations ◽  
Ulcer Disease

Objective — to analyze clinical neurological manifestations in patients suffering from peptic ulcer disease in the acute phase and in remission, based on the findings of a comprehensive clinical neurological, neuropsychological and paraclinical study. Methods and subjects.  84 patients suffering from PUD were comprehensively examined while in the acute phase of the disease and then all 84 were reexamined while in remission. The age range of the patients was from 25 to 60 years. The average age of the patient was 39.90 ± 1.29 years. The examined individuals were destributed into two groups based on whether they presented symptoms of an acute phase or remission of the peptic ulcer disease. The comprehensive examination included: interview and complaint analysis, neurological examination focused on the state of the autonomic nervous system, study of the neuropsychological differences (the trait and state anxiety levels monitoring based on the Spielberg‑Khanin scale, depressive state evaluation using Beck Depression Inventory, self‑perceived health assessment, mood and activity monitoring using the SAN questionnaire, cognitive impairment evaluation using the MMSE scale, assessment of the refocusing speeds and performance distribution using Schulte tables), as well as lab tests and procedures. Results. Most often, subjects complained of headache (74 (88.0 %) in the acute stage and 37 (44.0 %) in remission). The second most common was a complaint of pain in the thoracic spine (69 (82.1 %) and 35 (41.6 %), respectively). Complaints of dizziness, pain in the heart, palpitations, «interruptions» in the heart, paresthesia were often recorded. In 11 (12.4 %) patients with duodenal ulcer in the acute stage experienced episodes of syncopal state, while in the remission stage they were absent. Complaints that indicated the presence of psychoemotional disorders were anxiety, decreased memory and attention, and sleep disturbances. In patients with duodenal ulcer disease we revealed lesions of the central and peripheral nervous system. Central nervous system disorders were manifested in the form of vestibulo‑cerebellar syndrome (in 30 (35.7 %) patients in the acute stage and in 14 (16.6 %) in the remission stage), extrapyramidal disorders (respectively in 10 (11.9 %) and 4 (4.76 %)) and signs of pyramidal dysfunction (37 (44.0 %) and 15 (17.8 %)). Clinical and neurological examination of the peripheral nervous system in 68 (80.9 %) patients with peptic ulcer in the acute stage and in 31 (36.9 %) in the remission stage revealed polyneuropathy syndrome of varying degrees. Signs of polyneuropathy were accompanied by complaints of disorders of the peripheral nervous system (45 (53.5 %) and 15 (17.8 %) cases, respectively). In 27.4 % of patients with peptic ulcer disease in the acute stage of the complaint were absent at all, and only a thorough neurological examination revealed signs of polyneuropathy. In 56 (66.6 %) patients with peptic ulcer disease in the acute stage and 28 (33.3 %) in the remission stage, the morbidity of paravertebral points in the lower thoracic spine was revealed. Conclusions. Having analyzed the data obtained through the interviews, as well as the neurological characteristics of patients with peptic ulcer disease of the duodenum in the acute phase and in remission it was concluded that most of the somatic complaints and neurological manifestations were common in both the acute phase and the remission of the disease. However, all of the identified neurological differences were significantly more common in the acute phase of the disease.  

Features of the course of peptic ulcer disease in children and adolescents

1985 ◽  
Vol 66 (5) ◽  
pp. 377-377
Author(s):  
N. A. Cherkasova ◽  
H. S. Bikbulatova ◽  
V. N. Leonova
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Children And Adolescents ◽  
Ulcer Disease

There were 26 patients with gastric ulcer and duodenal ulcer (17 boys, 9 girls) aged from 9 to 18 years under observation.

THE STATE AND ROLE OF ESOPHAGUS, STOMACH, INTESTINAL MICROBIOTA IN PATIENTS WITH ULCER DISEASE, CHRONIC GASTRITIS, ESOPHAGITIS

2020 ◽  
Vol 65 (1) ◽  
pp. 42-49
Author(s):  
V. M. Chervinets ◽  
A. Yu. Mironov ◽  
Yu. V. Chervinets ◽  
S. N. Bazlov
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Mucous Membrane ◽  
Chronic Gastritis ◽  
Low Frequency ◽  
Duodenal Mucosa ◽  
Pathological Process ◽  
Quantitative Composition ◽  
Ulcer Disease ◽  
Opportunistic Bacteria

The microflora of 64 biopsies taken during fibrogastroduodenoscopy of the mucous membrane of the esophagus, stomach and duodenum in healthy volunteers and 1120 samples obtained from the same parts of the digestive tract in patients with esophagitis, chronic gastritis and peptic ulcer disease were studied. The patients ranged in age from 18 to 62 years. Traditional bacteriological method was used to isolate and identify microorganisms. Staphylococcus spp., Streptococcus spp., Lactobacillus spp., Bacteroides spp., Stomatococcus spp., Enterobacteriaceae, Corynebacterium spp., Micrococcus spp., Neisseria spp., Veilonella spp. were isolated from biopsies of healthy respondents in an average amount from 3.2 to 4.68 lg CFU/g. H.pylori was found in 60% (5.66 lg CFU/g) in the esophagus, in 33.3% of cases (5.12 lg CFU/g) from the fundal part of the stomach, in 44.4% (5.25 lg CFU/g) from the antral part of the stomach, in 5.5% (4.2 lg CFU/g) in the duodenal mucosa. In samples obtained from the inflamed and eroded mucous membrane of the esophagus, stomach and duodenum, opportunistic bacteria of the genera Klebsiella, Enterobacter, Proteus, Pseudomonas, Peptococcus, Actinomyces, yeast fungi of the genus Candida etc. were detected in an amount exceeding 4 lg CFU/g. H. pylori isolated in 6.3-16.7% of patients (4.25-4.6 lg CFU/g) and did not dominate in relation to other microorganisms, and in most cases had a low frequency of its occurrence. In patients with the recurrence of peptic ulcer disease, exacerbation of chronic gastritis and esophagitis, dysbiosis was developed, characterized by an increase in the species and quantitative composition of opportunistic microflora, an increase in its enzymatic and cytotoxic activity, which can contribute to the maintenance of inflammatory and necrotic processes and inhibit the elimination of the pathological process.

Features of Depressed State of Men with Sexual Disorders Based on Gastric Ulcer and Duodenal Ulcer

2016 ◽  
pp. 138-142
Author(s):  
Yurii Gurzhenko ◽  
Vasyl Soroka
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Research Evaluation ◽  
Close Correlation ◽  
Sexual Disorders ◽  
Ulcer Disease ◽  
Negative Effect ◽  
Personal Anxiety

The aim of the research: evaluation of the peculiarities of anxiety in male patients with gastric ulcer and duodenal ulcer, which are sexual disorders. Materials and methods. The research is based on the generalization of the results of complex examination and treatment of 130 patients with peptic ulcer of duodenum and stomach in remission who have sexual disorders. The patients were divided into three groups: basic, comparative and referential. Was used C. Spielberger’s self-evaluation scale of situational and personal anxiety and M. Kurgan’s methodology. Results. It has been proven that the level of personal anxiety has a close correlation with the duration of peptic ulcer disease. Conclusion. The presence of peptic ulcer disease creates a certain basis for further psychological stress, similar to negative effect with the development of sexual disorders. Among the examined patients prevailed the somatized nature of depression.

The duodenal mucosa in peptic ulcer disease

1962 ◽  
Vol 7 (6) ◽  
pp. 506-514 ◽  
Author(s):  
Alan R. Aronson ◽  
Robert G. Norfleet
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Duodenal Mucosa ◽  
Ulcer Disease

scholarly journals CLINICAL PROFILE AND RISK FACTORS FOR BENIGN PEPTIC ULCER DISEASE IN A TERTIARY CARE CENTRE IN THE SUBHIMALAYAN RANGES OF NORTH INDIA

2020 ◽  
pp. 1-3
Author(s):  
Vishal Bodh ◽  
Rajesh Sharma ◽  
Brij Sharma
Keyword(s):  
Risk Factors ◽  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Low Socioeconomic Status ◽  
Low Socioeconomic ◽  
Ulcer Disease ◽  
H Pylori ◽  
Upper Gastrointestinal

Background: To study the clinical profile and risk factors for benign peptic ulcer disease. Material and Methods: A total of 200 patients of peptic ulcer disease (PUD) diagnosed on upper gastrointestinal endoscopy were included. The socio-demographic profile, risk factors, clinical and endoscopic findings were recorded. Results: A total of 200 patients of peptic ulcer disease were included, out of which 168(84%) were males, while 32 (16%) were females. Most of the patients (61%) were between age 31-60 years with mean age of 47 years. Most of patients were farmers from rural areas and belonged to low socioeconomic status. History of smoking and alcohol intake was present in 106(53%) and 70( 35 %) patients respectively.Most common presenting complaints were epigastric pain and/or burning in 72 (36%) , followed by upper abdomen discomfort 70(35%) and upper gastrointestinal bleed 58(29%). Duodenal ulcer (DU) was present in 152 (76%), gastric ulcer(GU) in 30 (15%) while 18 (9%) had both DU and GU. Most of the patients had Forrest III ulcer 167 (83.5%) followed by Forrest IIc ulcer 13 (6.5%). H. pylori was detected by rapid urease test on endoscopic biopsy specimen in 156 (78 % ) of the total 200 patients of peptic ulcer disease. H. pylori was detected in 78.94 % case of DU, 60% case of GU and 100% cases of both DU and GU. Conclusion: PUD is a multifactorial health problem affecting almost all populations worldwide. . The major risk factors associated with PUD included tobacco and alcohol consumption besides low socioeconomic status, rural background and occupation of farming. Our findings indicate the substantial role of H. pylori and painkiller ingestion in the pathogenesis of PUD. Duodenal ulcer is most common type followed by gastric ulcer. Most had Forrest III ulcer followed by Forrest IIc.

scholarly journals S2307 A Case of Severe Peptic Ulcer Disease and Bleeding Duodenal Ulcer in a COVID-19 Patient

2021 ◽  
Vol 116 (1) ◽  
pp. S983-S983
Author(s):  
Nicole Farha ◽  
Clare Humphrey ◽  
K. James Kallail ◽  
William J. Salyers
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease ◽  
Bleeding Duodenal Ulcer

Changes in extracellular cyclic nucleotides in patients with peptic ulcer disease and chronic gastritis

1986 ◽  
Vol 67 (6) ◽  
pp. 401-403
Author(s):  
V. V. Trusov ◽  
Ya. M. Vakhrushev
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Oral Administration ◽  
Peptic Ulcer Disease ◽  
Chronic Gastritis ◽  
Cyclic Nucleotides ◽  
Peripheral Blood ◽  
Secretory Function ◽  
Ulcer Disease ◽  
Camp And Cgmp

The aim of this work was to study the peculiarities of changes in the levels of cyclic nucleotides (cAMP and cGMP) in peripheral blood during oral administration of solutions with different pH in patients with peptic ulcer disease and chronic gastritis. Studies were conducted in 55 patients, 23 of them had duodenal ulcer, 16 - chronic gastritis with decreased secretory function of the stomach.

Rationale improve diagnosis of sexual disorders in patients with somatic profile for example gastric ulcer and duodenal

2016 ◽  
pp. 60-64
Author(s):  
Y. Gurzhenko ◽  
◽  
V. Soroka ◽  
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Depressive Mood ◽  
Sexual Life ◽  
Sexual Disorders ◽  
Somatic Anxiety ◽  
Ulcer Disease ◽  
Low Level

The objective: The study and improvement of diagnosis of sexual disorders in patients of somatic profile, with ulcerative disease of the stomach (UDS) and peptic ulcer disease duodenal ulcer (DU). Patients and methods. For 3 years carried out a comprehensive examination and treatment of 130 patients with DU in remission and UDS in remission, which is observed sexual disorders; the first was 76 (58.5±4.3%) patients, second – 54 (41.5±4.3%); p<0.05. They represented the main group. The comparison group included 100 male patients with DU and UDS, which were also in remission, but did not complain of sexual disorders; accordingly, they were of 66.0±4.7% and 34.0±3.3%; p<0.05. Also was used a reference group (control) of 20 healthy men. All groups were matched for age (average age in the major groups – 34.0±1.7 years in the control to 32.0±4.0 years), and the first two – and duration of ulcer (average period in the history of 6.9±0.7 years). Results. The frequency of manifestations of depression in patients with DU and UDS with sexual disorders identified parameters, among which reliably allocated to mental anxiety (85.4±3.1%), depressive mood (73.1±3.8%), somatic anxiety (66.1±4.3%), reduced efficiency and activity (64.6±4.1 percent). Their combination in various embodiments burdened the situation. Exclusively in patients with peptic ulcer disease was most prevalent somatic anxiety (32.0±4.6%), depressive mood (28.0±4.5%), capacity and activity (24.0±4.2%). The majority of patients with DU and UDS with sexual disorders (60,8±4,2%) recorded a high level of personal anxiety and almost equally often low to moderate (19,2±3,4% and 20.0±3.4%, respectively). However, 93.0% of patients only with peptic ulcer were also noted its low level of expression. At the same time, among the first significantly more often observed the average level of situational anxiety (62.3±4.2%), every third - low (28.5±3.9%) and others (10.0 per cent), whereas among second - frequency dominated low level (63.0±4.9% vs 31.0±4.9% of the average and 6.0±2.3% - high). Conclusion. Justified the principle of improving the early identification of sexual disorders in men with chronic somatic diseases, for example peptic ulcer disease, the essence of which is to be included in the anamnestic and diagnostic method of two key issues, namely: the satisfaction of sexual intercourse and satisfaction with sexual life in General. Key words: gastric ulcer and duodenal ulcer, sexual dysfunction, diagnosis.

Sign in / Sign up

Export Citation Format

Share Document