scholarly journals In vivo toxicity study of dialkyl disulphides

2021 ◽  
Author(s):  
SA Kucherskoy ◽  
LA Alikbaeva
Keyword(s):  
Hazard Assessment ◽  
Intraperitoneal Injection ◽  
Inhalation Exposure ◽  
Toxicity Study ◽  
In Vivo Toxicity ◽  
Dimethyl Disulphide ◽  
Lethal Doses

As a result of the industrial purification of hydrocarbons from mercaptans, tens of thousands of tons of dialkyl disulphides and their mixtures, the toxicity and hazard of which has not been fully understood, are accumulated annually. The exposure standards have been developed only for dimethyl disulphide. The study was aimed to define toxicometry parameters for diethyl disulphide, disulphide oil, and the mixture of dialkyl disulphides. Toxicology studies involving male outbred rats made it possible to define the median lethal doses and concentrations: diethyl disulphide — after intragastric injection DL50 = 1575 mg/kg, after the 4-hour inhalation exposure CL50 = 18,700 mg/m3, after intraperitoneal injection DL50 = 1134 mg/kg, and after skin application DL50 ˃ 2500 mg/kg; mixture of dialkyl disulphides — after intragastric injection DL50 = 428 mg/kg, after the 4-hour inhalation exposure CL50 = 4510 mg/m3, after intraperitoneal injection DL50 = 212 mg/kg, and after skin application DL50 ˃ 2500 mg/kg; disulphide oil — after intragastric injection DL50 = 448 mg/kg, after the 4-hour inhalation exposure CL50 = 4534 mg/m3, after intraperitoneal injection DL50 = 156 mg/kg, and after skin application DL50 ˃ 2500 mg/kg. The hazard assessment for dialkyl disulphides and their mixtures was performed.

scholarly journals Development and Characterization of siRNA Lipoplexes: Effect of Different Lipids, In Vitro Evaluation in Cancerous Cell Lines and In Vivo Toxicity Study

2014 ◽  
Vol 15 (6) ◽  
pp. 1630-1643 ◽  
Author(s):  
Nirav Khatri ◽  
Dipesh Baradia ◽  
Imran Vhora ◽  
Mohan Rathi ◽  
Ambikanandan Misra
Keyword(s):  
Cell Lines ◽  
Toxicity Study ◽  
In Vitro Evaluation ◽  
In Vivo Toxicity ◽  
Cancerous Cell

scholarly journals Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration

2004 ◽  
Vol 5 (2) ◽  
pp. 17-23 ◽  
Author(s):  
Vanna Sanna ◽  
Nathalie Kirschvink ◽  
Pascal Gustin ◽  
Elisabeta Gavini ◽  
Isabelle Roland ◽  
...  
Keyword(s):  
Toxicity Study ◽  
In Vivo Toxicity ◽  
Pulmonary Administration ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

Protein phosphatase inhibition and in vivo hepatotoxicity of microcystins

1993 ◽  
Vol 265 (2) ◽  
pp. G224-G230 ◽  
Author(s):  
M. T. Runnegar ◽  
S. Kong ◽  
N. Berndt
Keyword(s):  
Protein Phosphatase ◽  
Intraperitoneal Injection ◽  
Significant Inhibition ◽  
Protein Phosphatase 1 ◽  
Liver Protein ◽  
Protein Phosphatase Inhibition ◽  
Clinical Changes ◽  
Dose Dependent ◽  
Lethal Doses

Administration of microcystin (MCYST)-YM or -LR (peptide hepatotoxins produced by the cyanobacterium Microcystis aeruginosa) to mice resulted in the inhibition of liver protein phosphatase 1 and 2A activity. In all cases significant inhibition preceded or accompanied clinical changes due to MCYST intoxication. Fifteen minutes after intraperitoneal injection of lethal doses of MCYST-YM protein phosphatase activity was already decreased to 44% of controls, and by 60 min was further decreased to 22% of controls. The inhibition was dose dependent: intraperitoneal injection with 84 nmol/kg of MCYST-YM and 48 nmol/kg of MCYST-LR were the minimum doses required for significant inhibition at 60 min. Pretreatment of mice with 200 mumol/kg of rifamycin prevented the inhibition of liver protein phosphatase. The inhibition was tissue specific, with none detected in the kidneys, an organ that, unlike the liver, does not accumulate MCYST. In contrast to MCYST intoxication, lethal doses of phalloidin, a peptide hepatotoxin that produces clinical and pathological changes similar to MCYST, did not cause any inhibition of protein phosphatases.

scholarly journals In vivo Toxicity Study and Antifilarial Activity of Four Plants from Nord-Cameroon

2017 ◽  
Vol 19 (3) ◽  
pp. 1-12 ◽  
Author(s):  
Ndjonka Dieudonné ◽  
Ayouba Mouraba ◽  
Ahamat Abakar ◽  
Djafsia Boursou ◽  
Ndouwe Honore
Keyword(s):  
Toxicity Study ◽  
In Vivo Toxicity ◽  
Antifilarial Activity

scholarly journals In Vivo Toxicity Study of Ethanolic Extracts of Evolvulus alsinoides & Centella asiatica in Swiss Albino Mice

2019 ◽  
Vol 7 (7) ◽  
pp. 1071-1076
Author(s):  
Mukesh Kumar Yadav ◽  
Santosh Kumar Singh ◽  
Manish Singh ◽  
Shashank Shekhar Mishra ◽  
Anurag Kumar Singh ◽  
...  
Keyword(s):  
Single Dose ◽  
Acute Toxicity ◽  
Centella Asiatica ◽  
Toxicity Study ◽  
Histopathological Analysis ◽  
Acute Administration ◽  
In Vivo Toxicity ◽  
Evolvulus Alsinoides ◽  
Ethanolic Extracts

AIM: We aimed to investigate several parameters after the in vivo acute and sub-acute administration of ethanolic extracts from E. alsinoides & C. asiatica. METHODS: Malignant Ovarian Germ Cell Tumors for in vivo toxicity study guidelines 423 and 407 of Organization for Economic Co-operation and Development (OECD) were followed for acute and sub-acute toxicity assays respectively. For LD50 evaluation, a single dose of ethanolic extracts of Evolvulus alsinoides L. (EEA) and ethanolic extracts of Centella asiatica (ECA) was orally administered to mice at doses of 200, 400, 800, 1600 and 2000 mg/kg. Then the animals were observed for 72 hours. For acute toxicity evaluation, a single dose of both extracts was orally administered to mice at doses of 300, 600, 1200 and 2000 mg/kg and the animals were observed for 14 days. In the sub-acute study, the extracts were orally administered to mice for 28 days at doses of 300, 600, 1200 and 2000 mg/kg. To assess the toxicological effects, animals were closely observed on general behaviour, clinical signs of toxicity, body weight, food and water intake. At the end of the study, it was performed biochemical and hematological evaluations, as well as histopathological analysis from the following organs: brain, heart, liver, and kidney. RESULTS: The oral administration of E. alsinoides and C. asiatica ethanolic extracts, i.e. EEA 300, EEA 600, EEA 1200, EEA 2000, ECA 300, ECA 600, ECA 1200 & ECA 2000 mg/kg doses showed no moral toxicity effect in LD50, acute and sub-acute toxicity parameters. CONCLUSION: In this study, we had found that E. alsinoides & C. asiatica extract at different doses cause no mortality in acute and sub-acute toxicity study. Also, histopathology of kidney, liver, heart, and brain showed no alterations in tissues morphology.

scholarly journals In vivo toxicity study of Lantana camara

2011 ◽  
Vol 1 (3) ◽  
pp. 230-232 ◽  
Author(s):  
Badakhshan Mahdi Pour ◽  
Sreenivasan Sasidharan
Keyword(s):  
Lantana Camara ◽  
Toxicity Study ◽  
In Vivo Toxicity

scholarly journals Felodipine loaded PLGA nanoparticles: preparation, physicochemical characterization and in vivo toxicity study

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Utpal Jana ◽  
Anjan Kumar Mohanty ◽  
Sovan Lal Pal ◽  
Prabal Kumar Manna ◽  
Guru Prasad Mohanta
Keyword(s):  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
Toxicity Study ◽  
In Vivo Toxicity

scholarly journals In Vivo Toxicity Study of Engineered Lipid Microbubbles in Rodents

ACS Omega ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 5526-5533 ◽  
Author(s):  
Gaio Paradossi ◽  
Letizia Oddo ◽  
Barbara Cerroni ◽  
Carmit Ben-Harush ◽  
Eti Ariel ◽  
...  
Keyword(s):  
Toxicity Study ◽  
In Vivo Toxicity

In vivo toxicity study of N-1-sulfonylcytosine derivatives and their mechanisms of action in cervical carcinoma cell line

2011 ◽  
Vol 30 (3) ◽  
pp. 981-990 ◽  
Author(s):  
Jelena Kašnar-Šamprec ◽  
Ivana Ratkaj ◽  
Katarina Mišković ◽  
Marina Pavlak ◽  
Mirela Baus-Lončar ◽  
...  
Keyword(s):  
Cell Line ◽  
Cervical Carcinoma ◽  
Carcinoma Cell ◽  
Mechanisms Of Action ◽  
Carcinoma Cell Line ◽  
Toxicity Study ◽  
In Vivo Toxicity ◽  
Cervical Carcinoma Cell Line
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