scholarly journals Primitive Neuroectodermal Tumor of Axilla in an Adult: A Rare Entity

2021 ◽  
Vol 3 (2) ◽  
pp. 1-2
Author(s):  
Shravan S Shetty ◽  
◽  
Vidhi Shah ◽  
Eshpuniyani Prriya Prriya ◽  
◽  
...  
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Subcutaneous Tissue ◽  
Neuroectodermal Tumor ◽  
Round Cell ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Poorly Differentiated ◽  
The Right ◽  
Disease Free

Primitive neuroectodermal tumors (PNETs) are poorly differentiated small round cell neoplasms which mainly affect children and are not commonly seen in adults. Superficial primitive neuroectodermal tumors are rare and have a favourable prognosis compared to conventional deep seated tumors. We report a case of a 62 year old gentleman with a primitive neuroectodermal tumor arising from the subcutaneous tissue of the right axilla. He was treated with multimodal treatment including surgery and radiotherapy. He is alive and disease free at 2 year follow up.

Primitive Neuroectodermal Tumor of Axilla in an Adult: A Rare Entity

2021 ◽  
pp. 1-2
Author(s):  
Shetty Shravan S ◽  
◽  
Shah Vidhi ◽  
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Subcutaneous Tissue ◽  
Neuroectodermal Tumor ◽  
Round Cell ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Poorly Differentiated ◽  
The Right ◽  
Disease Free

Primitive neuroectodermal tumors (PNETs) are poorly differentiated small round cell neoplasms which mainly affect children and are not commonly seen in adults. Superficial primitive neuroectodermal tumors are rare and have a favourable prognosis compared to conventional deep seated tumors. We report a case of a 62 year old gentleman with a primitive neuroectodermal tumor arising from the subcutaneous tissue of the right axilla. He was treated with multimodal treatment including surgery and radiotherapy. He is alive and disease free at 2 year follow up

Intracranial Peripheral Primitive Neuroectodermal Tumors of the Cavernous Sinus: A Diagnostic Peculiarity

2005 ◽  
Vol 129 (1) ◽  
pp. e11-e15 ◽  
Author(s):  
Muhammad Idrees ◽  
Chirag Gandhi ◽  
Simone Betchen ◽  
James Strauchen ◽  
Wesley King ◽  
...  
Keyword(s):  
Cavernous Sinus ◽  
Ewing Sarcoma ◽  
Moderate Amount ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Male Preponderance ◽  
Poorly Differentiated ◽  
Immunohistochemical Techniques ◽  
The Right ◽  
Peripheral Primitive Neuroectodermal Tumors

Abstract Peripheral primitive neuroectodermal tumors (pPNETs) are aggressive, poorly differentiated neoplasms that occur in children and young adults. These tumors are associated with a peak incidence in the second decade and a slight male preponderance. Recently, Ewing sarcoma and pPNET tumors have been proven to carry identical translocations, the most common being t(11;22)(q24;q12). Intracranial Ewing sarcoma/pPNETs have rarely been described in the literature. We studied a case of intracranial pPNET arising in the right cavernous sinus of a 46-year-old man. On imaging, the tumor had both sellar and suprasellar components and was centered within the right parasellar region. Histologically, the tumor was composed of intermediate to large cells with round to oval hyperchromatic nuclei with distinct nucleoli. The cells contained a moderate amount of slightly basophilic cytoplasm. The tumor was markedly fibrotic and had collagen bands surrounding both individual and groups of cells. A large immunohistochemical panel was positive only for CD99 and vimentin. Fluorescence in situ hybridization did not show translocations associated with Ewing sarcoma/pPNET. However, a small percentage of these tumors can be negative for this translocation. In these cases, histology and immunohistochemical techniques in the absence of an alternative diagnosis are the only tools available to establish the diagnosis.

Primitive Neuroectodermal Tumor of the Lung

2001 ◽  
Vol 125 (3) ◽  
pp. 397-399
Author(s):  
Andrea G. Kahn ◽  
Alejandra Avagnina ◽  
Jorge Nazar ◽  
Boris Elsner
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Neuron Specific Enolase ◽  
Middle Lobe ◽  
Neurosecretory Granules ◽  
Primitive Neuroectodermal Tumors ◽  
Ultrastructural Studies ◽  
Neuroectodermal Tumors ◽  
Right Middle Lobe ◽  
Cytoplasmic Processes

Abstract Primitive neuroectodermal tumors occur most frequently in bone and soft tissue but have been reported in other locations. Primary lung primitive neuroectodermal tumors without pleural or chest wall involvement are extremely rare. We present a case with immunohistochemical and ultrastructural studies and follow-up of the patient. An 18-year-old man presented with hemoptysis. Chest radiographs revealed a right middle lobe mass, and bronchoscopy showed an endobronchial tumor. The lesion was resected by middle lobectomy. After 2 years, a local recurrence was treated by pneumonectomy. The patient died after surgery. Histologically, the tumor was composed of uniform cells with round nuclei and scanty cytoplasm arranged in cohesive lobules with occasional rosette formation. Immunohistochemically, the tumor was positive for vimentin, CD99, neuron-specific enolase, and neurofilaments. Ultrastructural study revealed neurosecretory granules and cytoplasmic processes. Our case shows the value of immunohistochemistry and electron microscopy in the diagnosis of primitive neuroectodermal tumors in unusual locations.

scholarly journals Renal Primitive Neuroectodermal Tumors

2012 ◽  
Vol 136 (6) ◽  
pp. 686-690 ◽  
Author(s):  
Tanner Bartholow ◽  
Anil Parwani
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Correct Diagnosis ◽  
Age Distribution ◽  
Disease Free Survival ◽  
Neuroectodermal Tumor ◽  
Renal Tumors ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Genetic Abnormalities ◽  
Disease Free Survival Rate

Primitive neuroectodermal tumors exist as a part of the Ewing sarcoma/primitive neuroectodermal tumor family. These tumors most commonly arise in the chest wall and paraspinal regions; cases with a renal origin are rare entities, but have become increasingly reported in recent years. Although such cases occur across a wide age distribution, the average age for a patient with a renal primitive neuroectodermal tumor is the mid- to late 20s, with both males and females susceptible. Histologically, these tumors are characterized by pseudorosettes. Immunohistochemically, CD99 is an important diagnostic marker. Clinically, these are aggressive tumors, with an average 5-year disease-free survival rate of only 45% to 55%. Given that renal primitive neuroectodermal tumor bears many similarities to other renal tumors, it is important to review the histologic features, immunostaining profile, and genetic abnormalities that can be used for its correct diagnosis.

scholarly journals Primary Pulmonary Primitive Neuroectodermal Tumor: A Case Report and Literature Review

2020 ◽  
pp. 1-3
Author(s):  
Guzmán-Casta Jordi
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Chest Wall ◽  
Primitive Neuroectodermal Tumor ◽  
Lung Parenchyma ◽  
Round Cell ◽  
Primitive Neuroectodermal Tumors ◽  
Small Round Cell ◽  
Molecular Features ◽  
Neuroectodermal Tumors

Primitive Neuroectodermal Tumors (PNET) and Ewing Sarcoma (EWS) belong to the same family of malignant, small, round cell neoplasms of soft tissue or bone origin. Common locations for EWS-PNET include chest wall, pelvis, and extremities. EWSPNETs that arise in the lung parenchyma without chest wall involvement are extremely rare in adults. We report a case of EWS-PNET of the lung in an adult and review the distinct clinical, pathological, and molecular features of these tumors.

Peripheral Primitive Neuroectodermal Tumor (pPNET) of the Penis: A Case Report and Literature Review

2015 ◽  
Vol 100 (9-10) ◽  
pp. 1340-1345
Author(s):  
Wanqiu Huang ◽  
Zheng Liu ◽  
Ruibao Chen ◽  
Tao Wang ◽  
Ruzhu Lan ◽  
...  
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Initial Symptom ◽  
Positive Staining ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
Ki 67 ◽  
Primitive Neuroectodermal Tumors ◽  
Atypical Symptoms ◽  
Neuroectodermal Tumors ◽  
Low Incidence

Primitive neuroectodermal tumors are derived from primitive neuroectodermal cells and belong to a highly malignant subgroup of round-cell tumors. Peripheral primitive neuroectodermal tumors of the penis are an extremely rare malignant form among penile neoplasms. These tumors are often difficult to diagnose due to atypical symptoms. Here, we report a case of a 24-year-old patient in China with a neoplasm localized at the base of his penis. The initial symptom was dysuria without any inducement. The results of blood and urine examinations indicated no abnormalities. The imaging examination results indicated a firm mass near the base of the penis. The hematoxylin and eosin (H&E) staining revealed round, small tumor cells with heterotypical darkened nuclei. In addition, immunohistochemistry (IHC) revealed strong and diffuse positive staining for CD99 (mic-2), VIM (vimentin), and NCAM1/CD56 (neural cell adhesion molecule 1). In addition, 60% of cells were positive for the cell proliferation marker Ki-67. Based on the above results, the case was diagnosed with peripheral primitive neuroectodermal tumor (pPENT). We reviewed the literature from 1999 to 2013 and identified reports of pPENT with a low incidence and atypical symptoms. Accurate diagnosis with multiple detection technologies, including laboratory diagnostic tests, imaging, morphologic and immunologic examinations, is very important to reduce the misdiagnosis rate.

scholarly journals Primitive Neuroectodermal Tumor of the Pancreas: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Uirá Teixeira ◽  
Marcos Goldoni ◽  
Michelle Unterleider ◽  
João Diedrich ◽  
Diogo Balbinot ◽  
...  
Keyword(s):  
Case Report ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Neuroendocrine Cells ◽  
Malignant Neoplasms ◽  
Review Of The Literature ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors

Primitive neuroectodermal tumors (PNETs) are presented as rare malignant neoplasms. In unusual cases, those neoplasms may arise in solid organs containing neuroendocrine cells, such as the pancreas. Herein the case of a 28-year-old patient that underwent gastroduodenopancreatectomy after the diagnosis of a huge mass (PNET) located in both head and body of the pancreas is reported. This is the 19th case of pancreatic PNET reported in literature.

Congenital primary primitive neuroectodermal tumor of the orbit in a newborn

2021 ◽  
pp. 112067212199104
Author(s):  
Nirupama Kasturi ◽  
Sandip Sarkar ◽  
Tanmay Gokhale ◽  
Subashini Kaliaperumal ◽  
Pampa Ch Toi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Rare Case ◽  
Primitive Neuroectodermal Tumor ◽  
Histopathological Examination ◽  
Neuroectodermal Tumor ◽  
Multidisciplinary Management ◽  
Case Presentation ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
The Central Nervous System

Introduction: Primitive neuroectodermal tumors arise from the progenitor cells of the neural crest, in the central nervous system or other peripheral locations. Case presentation: We report a rare case of a congenital malignant tumor, diagnosed as a primary orbital primitive neuroectodermal tumor on histopathological examination. Conclusion: Multidisciplinary management with adjuvant chemotherapy needed for the management of these cases.

scholarly journals Extraneural Supratentorial Primitive Neuroectodermal Tumor Metastasis: An Adult Case Report

2017 ◽  
Vol 06 (03) ◽  
pp. 210-212 ◽  
Author(s):  
Nidhal Matar ◽  
Kamel Bahri ◽  
Jallel Kallel ◽  
Adnene Boubaker ◽  
Hafedh Jemel
Keyword(s):  
Case Report ◽  
Tumor Metastasis ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Adult Case ◽  
Primitive Neuroectodermal Tumors ◽  
Extraneural Metastases ◽  
Supratentorial Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumors ◽  
Sporadic Cases

AbstractExtraneural metastases of supratentorial primitive neuroectodermal tumors (PNET) are very rare and have been reported in only sporadic cases. We present a patient with supratentorial PNET metastasizing to the lung, diagnosed 4 months after cerebral surgery.

scholarly journals Primary Primitive Neuroectodermal Tumor of the Parotid: An Unsuspected Diagnosis

2020 ◽  
Vol 1 (1) ◽  
pp. 01-03
Author(s):  
Yahyaoui Yosra
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Head And Neck ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Primitive Neuroectodermal Tumors ◽  
Rare Tumors ◽  
Neuroectodermal Tumors ◽  
The Central Nervous System

Primitive neuroectodermal tumors (PNETs) are extremely rare tumors. These neoplasms can occur at sites outside of the central nervous system. The head and neck location is unsual. We report a case with primitive neuroectodermal tumor (PNET) of the parotid. We analyze through this observation the clinical, histological and therapeutic characteristics of this entity.

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