Opinion of the Pathogenesis of the Mumps Meningites

2020 ◽  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Choroid Plexus ◽  
Present Article ◽  
Clinical Data ◽  
Fluid Secretion ◽  
Mumps Virus ◽  
Direct Involvement ◽  
Glymphatic System ◽  
Cerebrospinal Fluid Secretion

It is generally accepted that meningeal reactions in patients with mumps are due to the direct involvement of the meninges by the mumps virus. With the development of mumps vaccines, this view was extended to vaccinated people, who are considered serious post-vaccine meningitis. In present article, the author states that these reactions are not due to inflammation of the meninges, but to the choroid plexus caused by virulent and vaccine strains. Inflammation leads to an increase in cerebrospinal fluid secretion, which increases intracranial pressure and is manifested by meningeal symptoms. In the presence of this evidence, the author considers that meningeal reactions are not meningitis, but meningisms, based on clinical data, experiments on monkeys and the glymphatic system.

The GLP-1R agonist exendin-4 reduces cerebrospinal fluid secretion and intracranial pressure

2017 ◽  
Author(s):  
Hannah Botfield ◽  
Maria Uldall ◽  
Connar Westgate ◽  
James Mitchell ◽  
Snorre Hagen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Fluid Secretion ◽  
Cerebrospinal Fluid Secretion

scholarly journals Cerebrospinal fluid secretion by the choroid plexus?

2016 ◽  
Vol 96 (4) ◽  
pp. 1661-1662 ◽  
Author(s):  
Darko Orešković ◽  
Milan Radoš ◽  
Marijan Klarica
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Fluid Secretion ◽  
Cerebrospinal Fluid Secretion

Papilledema

2019 ◽  
pp. 41-46
Author(s):  
Matthew J. Thurtell ◽  
Robert L. Tomsak
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Fluid Secretion ◽  
Management Approach ◽  
Fluid Absorption ◽  
Increased Intracranial Pressure ◽  
Absorption Increase ◽  
Cerebrospinal Fluid Absorption ◽  
Symptoms And Signs ◽  
Cerebrospinal Fluid Secretion

Papilledema is the cardinal clinical sign of increased intracranial pressure. In this chapter, we begin by reviewing the symptoms and signs of increased intracranial pressure. We next review potential causes of increased intracranial pressure, which include intracranial masses, obstruction of the ventricular system, obstruction of cerebral venous outflow, decrease in cerebrospinal fluid absorption, increase in cerebrospinal fluid secretion, cerebral edema, medications, and idiopathic intracranial hypertension. We then review the approach to the diagnostic evaluation of increased intracranial pressure, including the recommended neuroimaging studies and cerebrospinal fluid evaluation. Lastly, we discuss the basic management approach for the patient with symptoms and signs of increased intracranial pressure.

scholarly journals Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus

2022 ◽  
Author(s):  
Dagne Barbuskaite ◽  
Eva Kjer Oernbo ◽  
Jonathan Henry Wardman ◽  
Trine Lisberg Toft-Bertelsen ◽  
Eller Conti ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Ex Vivo ◽  
Direct Action ◽  
Fluid Secretion ◽  
Carbonic Anhydrases ◽  
Patient Groups ◽  
Systemic Side Effects ◽  
Cerebrospinal Fluid Secretion

Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is routinely relieved with neurosurgical approaches, since effective and targeted pharmacological tools are still lacking. The carbonic anhydrase inhibitor, acetazolamide (AZE), may be employed to treat elevated ICP. However, its effectiveness is questioned, its location of action unresolved, and its tolerability low. Here, we employed in vivo and ex vivo approaches to reveal the efficacy and mode of action of AZE in the rat brain. The drug effectively reduced the ICP, irrespective of the mode of drug administration and level of anaesthesia. The effect occurred via a direct action on the choroid plexus and an associated decrease in cerebrospinal fluid secretion, and not indirectly via the systemic action of AZE on renal and vascular processes. Upon a single administration, the reduced ICP endured for approximately 10 h post-AZE delivery with no long-term changes of brain water content or choroidal transporter expression. However, a persistent reduction of ICP was secured with repeated AZE administrations throughout the day. Future specific targeting of choroidal carbonic anhydrases may limit the systemic side effects, and therefore enhance the treatment tolerability and effectiveness in select patient groups experiencing elevated ICP.

scholarly journals Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats

2017 ◽  
Vol 645 ◽  
pp. 33-39 ◽  
Author(s):  
Maria Uldall ◽  
Hannah Botfield ◽  
Inger Jansen-Olesen ◽  
Alexandra Sinclair ◽  
Rigmor Jensen
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Fluid Secretion ◽  
Secretion Pathway ◽  
Cerebrospinal Fluid Secretion

scholarly journals Cerebrospinal Fluid Secretion by the Choroid Plexus

2013 ◽  
Vol 93 (4) ◽  
pp. 1847-1892 ◽  
Author(s):  
Helle H. Damkier ◽  
Peter D. Brown ◽  
Jeppe Praetorius
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Epithelial Transport ◽  
Cell Monolayer ◽  
Fluid Secretion ◽  
Transport Proteins ◽  
High Rate ◽  
Electrolyte Balance ◽  
Cuboidal Cell ◽  
Cerebrospinal Fluid Secretion

The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins mediates the transepithelial movement of solutes and water across the epithelium. Secretion by the choroid plexus is characterized by an extremely high rate and by the unusual cellular polarization of well-known epithelial transport proteins. This review focuses on the specific ion and water transport by the choroid plexus cells, and then attempts to integrate the action of specific transport proteins to formulate a model of cerebrospinal fluid secretion. Significant emphasis is placed on the concept of isotonic fluid transport across epithelia, as there is still surprisingly little consensus on the basic biophysics of this phenomenon. The role of the choroid plexus in the regulation of fluid and electrolyte balance in the central nervous system is discussed, and choroid plexus dysfunctions are described in a very diverse set of clinical conditions such as aging, Alzheimer's disease, brain edema, neoplasms, and hydrocephalus. Although the choroid plexus may only have an indirect influence on the pathogenesis of these conditions, the ability to modify epithelial function may be an important component of future therapies.

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