АNTIOXIDANT AND ANTIRADICAL PROPERTIES DINITROSYL IRON COMPLEXES UNDER CONDITIONS SIMULATING OXIDATIVE STRESS

2021 ◽  
Author(s):  
Konstantin Shumaev ◽  
◽  
Olga Kosmachevskaya ◽  
Dmitry Ivanovich Grachev ◽  
Alexey Topunov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Co Oxidation ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Butyl Hydroperoxide ◽  
Antiradical Properties ◽  
Tert Butyl Hydroperoxide ◽  
Different Types ◽  
Dinitrosyl Iron

We have demonstrated that dinitrosyl iron complexes (DNICs) eliminate free radicals formed during the interaction of hemoproteins with tert-butyl hydroperoxide, as well as during the co-oxidation of lipids and glucose. Thus, DNICs act as antioxidants under conditions simulating different types of oxidative stress.

Possible mechanism of antioxidant action of dinitrosyl iron complexes

2021 ◽  
Vol 67 (2) ◽  
pp. 162-168
Author(s):  
K.B. Shumaev ◽  
O.V. Kosmachevskaya ◽  
D.I. Grachev ◽  
A.A. Timoshin ◽  
A.F. Topunov ◽  
...  
Keyword(s):  
Free Radical ◽  
Co Oxidation ◽  
Free Radical Oxidation ◽  
Iron Complexes ◽  
Antioxidant Effect ◽  
Dinitrosyl Iron Complexes ◽  
Model Systems ◽  
Intramolecular Rearrangement ◽  
Antioxidant Action ◽  
Dinitrosyl Iron

The antioxidant effect of dinitrosyl iron complexes (DNICs) was studied in various model systems. DNICs with glutathione ligands effectively inhibited Cu2+-induced peroxidation of low density lipoproteins (LDL). The antioxidant effect of DNICs with phosphate ligands and free reduced glutathione (GSH) was less pronounced. In addition, DNICs with glutathione suppressed the formation of reactive oxygen species during co-oxidation of lecithin liposomes and glucose. Free radical oxidation in this system was induced with a lipophilic azo initiator and evaluated by luminol-dependent chemiluminescence. NO sharply stimulated chemiluminescence during co-oxidation of glucose and liposomes, thus suggesting the formation of potent oxidants under these conditions. Glutathione DNICs scavenge the superoxide radical anion generated in the xanthine-xanthine oxidase system. Superoxide production was assessed by lucigenin-dependent chemiluminescence and electron paramagnetic resonance (EPR) spectroscopy. Chemiluminescence revealed the dose-dependent character of antiradical effect of glutathione DNICs; moreover, these complexes turned out to be more efficient than GSH. EPR spectra of the adducts of the DEPMPO spin trap with free radicals suggest that the interaction of glutathione DNICs and superoxide does not result in the formation of the thiyl radical of glutathione. Here we propose a mechanism of the antioxidant action of glutathione DNICs, suggesting that unstable intermediate complexes are formed upon their interaction with superoxide or lipid radicals. Further, as a result of intramolecular rearrangement, these intermediates decompose without the free radical as the by-products.

Dinitrosyl Iron Complexes Bind with Hemoglobin as Markers of Oxidative Stress

2008 ◽  
pp. 445-461 ◽  
Author(s):  
Konstantin B. Shumaev ◽  
Olga V. Kosmachevskaya ◽  
Alexander A. Timoshin ◽  
Anatoly F. Vanin ◽  
Alexey F. Topunov
Keyword(s):  
Oxidative Stress ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron ◽  
Markers Of Oxidative Stress

Dinitrosyl Iron Complexes in Barotrauma Damage to Viscera under Oxidative Stress

2005 ◽  
Vol 405 (1-6) ◽  
pp. 392-394
Author(s):  
G. N. Bogdanov ◽  
S. V. Mishchenko ◽  
V. N. Varfolomeev ◽  
V. N. Shtol'ko
Keyword(s):  
Oxidative Stress ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes of Human Fibroblasts

2018 ◽  
Vol 483 (4) ◽  
pp. 452-456
Author(s):  
A. Gizatullin ◽  
◽  
N. Akent'eva ◽  
N. Sanina ◽  
N. Shmatko ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Metabolic Processes ◽  
No Donors ◽  
Dinitrosyl Iron

The Influence of the Nature of the Ligand on the Antitumor Activity and Cytotoxic Effect of Binuclear Dinitrosyl Iron Complexes

BIOPHYSICS ◽  
2020 ◽  
Vol 65 (5) ◽  
pp. 863-868
Author(s):  
A. F. Vanin ◽  
L. A. Ostrovskaya ◽  
D. B. Korman ◽  
E. I. Nekrasova ◽  
O. O. Riabaya ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cytotoxic Effect ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Re-examination of the formation of dinitrosyl–iron complexes during reaction of S-nitrosothiols with Fe(II)

2001 ◽  
Vol 318 (1-2) ◽  
pp. 1-7 ◽  
Author(s):  
Simona Costanzo ◽  
Stephane Ménage ◽  
Roberto Purrello ◽  
Raffaele P Bonomo* ◽  
Marc Fontecave*
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron
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