Quality by Design: A Methodical Approach in Development of Nano Delivery System
Pharmaceutical quality by design (QbD) is a methodical approach to development of drug which begins with predefined objectives and control based on scientific acumen and quality risk management. QbD in the field of pharmacy is based on the basic understanding of the quality profile of final products affects by materials and process parameters. The application of QbD in designing of drug delivery system is based on a sound understanding of the sources of variability and the manufacture process and parameters. Most of problems in quality in formulations are related to the way designing of pharmaceutical product was carried out. The most important element of QbD based drug delivery development is the risk assessment (RA) activity which is important aspect during the development process. This review article addressed various concepts and applications od QbD to optimize and develop various nano drug delivery systems such as, examples liposomes, proliposome, nanoliposomes, polymeric nanoparticles, microsponges, solid lipid nanoparticles, transgel. nanostructured lipid carriers, nano emulsions with the research published in recent years.
