Total corpus callosum volume in patients with systemic lupus erythematosus according to age at disease onset - a longitudinal study

Objective The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characteristics. Patients and method This population-based, multicenter, cross-sectional study included 3661 adult SLE patients from Egyptian rheumatology departments across the nation. Demographic, clinical, and therapeutic data were assessed for all patients. Results The study included 3661 patients; 3296 females and 365 males (9.03:1) and the median age was 30 years (17–79 years), disease duration 4 years (0–75 years) while the median age at disease onset was 25 years (4–75 years). The overall estimated prevalence of adult SLE in Egypt was 6.1/100,000 population (1.2/100,000 males and 11.3/100,000 females).There were 316 (8.6%) juvenile-onset (Jo-SLE) and 3345 adult-onset (Ao-SLE). Age at onset was highest in South and lowest in Cairo (p < 0.0001). Conclusion SLE in Egypt had a wide variety of clinical and immunological manifestations, with some similarities with that in other nations and differences within the same country. The clinical characteristics, autoantibodies and comorbidities are comparable between Ao-SLE and Jo-SLE. The frequency of various clinical and immunological manifestations varied between gender. Additional studies are needed to determine the underlying factors contributing to gender and age of onset differences.

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Longitudinal study of the impact of incident organ manifestations and increased disease activity on work loss among persons with systemic lupus erythematosus

Arthritis Care & Research ◽

10.1002/acr.20669 ◽

2012 ◽

Vol 64 (2) ◽

pp. 169-175 ◽

Cited By ~ 17

Author(s):

Edward Yelin ◽

Chris Tonner ◽

Laura Trupin ◽

Stuart A. Gansky ◽

Laura Julian ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Longitudinal Study ◽

Disease Activity ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Work Loss ◽

Organ Manifestations ◽

The Impact

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Systemic lupus erythematosus in three ethnic groups: I. The effects of HLA class II, C4, and CR1 alleles, socioeconomic factors, and ethnicity at disease onset

Arthritis & Rheumatism ◽

10.1002/1529-0131(199807)41:7<1161::aid-art4>3.0.co;2-k ◽

1998 ◽

Vol 41 (7) ◽

pp. 1161-1172 ◽

Cited By ~ 169

Author(s):

John D. Reveille ◽

Joann M. Moulds ◽

Chul Ahn ◽

Alan W. Friedman ◽

Bruce Baethge ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Socioeconomic Factors ◽

Ethnic Groups ◽

Lupus Erythematosus ◽

Disease Onset ◽

Class Ii ◽

Hla Class Ii ◽

Systemic Lupus

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Lupus-related vasculitis in a cohort of systemic lupus erythematosus patients

Archives of Rheumatology ◽

10.46497/archrheumatol.2021.8804 ◽

2021 ◽

Vol 36 (4) ◽

pp. 595-692

Author(s):

Sherif M Gamal ◽

Sally S. Mohamed ◽

Marwa Tantawy ◽

Ibrahem Siam ◽

Ahmed Soliman ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Disease Duration ◽

Laboratory Data ◽

Disease Onset ◽

Damage Index ◽

Livedo Reticularis ◽

Treatment Modalities ◽

Systemic Lupus ◽

Hematological Manifestations

Objectives: This study aims to examine the frequency and clinical association of lupus-related vasculitis in patients with systemic lupus erythematosus (SLE). Patients and methods: We retrospectively analyzed medical records of a total of 565 SLE patients (42 males, 523 females; mean age: 32.7±9.5 years; range, 13 to 63 years) between January 2017 and February 2020. Demographic, clinical data, and laboratory data and treatment modalities applied were recorded. Lupus-related vasculitis and its different types were documented, and the patients with vasculitis were compared with those without vasculitis. Results: The mean disease duration was 8.9±6.3 years. Vasculitis associated with lupus was found in 191 (33.45%) patients. Cutaneous vasculitis was found in 59.2%, visceral vasculitis in 34.0%, and both in 6.8% of total vasculitis patients. The patients with vasculitis had a longer disease duration (p=0.01), were more likely to have juvenile onset (p=0.002), livedo reticularis (p<0.001), Raynaud's phenomenon (RP) (p<0.001), digital gangrene (p<0.001), thrombosis (p=0.003), and cranial neuropathy (p=0.004). The patients with vasculitis showed a higher prevalence of hypercholesterolemia (p=0.045), diabetes mellitus (p=0.026), higher Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) at disease onset (p<0.001), and Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (p=0.003) scores. They had more prevalent hematological manifestations (p<0.001), hypocomplementemia (p=0.007), received a higher cumulative dose of intravenous methylprednisolone (p<0.001), and had also more frequent cyclophosphamide (p=0.016) and azathioprine intake (p<0.001). In the logistic regression analysis, SLE vasculitis was independently associated with juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher scores of SLEDAI at disease onset (p<0.05). Conclusion: Juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher SLEDAI scores at disease onset may be associated with the development of vasculitis in SLE patients.

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