scholarly journals An Easy Construction of Generalized Neighbor Designs in Minimal Circular Blocks

2021 ◽  
Author(s):  
Muhammad Nadeem ◽  
◽  
Muhammad Rasheed ◽  
M. H. Tahir ◽  
Khadija Noreen ◽  
...  

Neighbor designs are used in the experiments where neighbor effects may arise. Neighbor designs neutralize these effects and are, therefore, considered to be robust against neighbor effects. Minimal neighbor designs are always most economical among the neighbor designs and are, therefore, preferred by the experimenters. Method of cyclic shifts provides these designs in circular blocks only for odd v (number of treatments). For v even, minimal circular generalized neighbor designs in which only v 2 unordered pairs of distinct treatments do not appear as neighbors will be the better alternate to the minimal neighbor designs. In this article, such minimal generalized neighbor designs are constructed in circular blocks for v even.

1991 ◽  
Vol 166 (1) ◽  
pp. 151-159
Author(s):  
Carmen Lucia C. Ochi ◽  
Belita Koiller
Keyword(s):  

Author(s):  
Wenbo Fu ◽  
Qiushi Li ◽  
Yongshun Song ◽  
Yaogen Shu ◽  
Zhongcan Ouyang ◽  
...  

Abstract The fidelity of DNA transcription catalyzed by RNA polymerase (RNAP) has long been an important issue in biology. Experiments have revealed that RNAP can incorporate matched nucleotides selectively and proofread the incorporated mismatched nucleotides. However, systematic theoretical researches on RNAP fidelity are still lacking. In the last decade, several theories on RNA transcription have been proposed, but they only handled highly simplified models without considering the high-order neighbor effects and the oligonucleotides cleavage both of which are critical for the overall fidelity. In this paper, we regard RNA transcription as a binary copolymerization process and calculate the transcription fidelity by the steady-state copolymerization theory recently proposed by us for DNA replication. With this theory, the more realistic models considering higher-order neighbor effects, oligonucleotides cleavage, multi-step incorporation and multi-step cleavage can be rigorously handled.


Author(s):  
Maxime Crochemore ◽  
Costas S. Iliopoulos ◽  
Jakub Radoszewski ◽  
Wojciech Rytter ◽  
Juliusz Straszyński ◽  
...  
Keyword(s):  

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