scholarly journals Clinical Statistical Analysis with Comparison between Pelvic and Non-pelvic Chondrosarcoma

2021 ◽  
Vol 36 (3) ◽  
pp. e271-e271
Author(s):  
Sayed Abdulla Jami1, ◽  
Shi Jiandang ◽  
Brotendu Shekhar Roy ◽  
Zhanwen Zhou ◽  
Liu Chang Hao
Keyword(s):  
Prognostic Factors ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Local Recurrence Rate ◽  
Survival Rates ◽  
Significant Difference ◽  
Grade Ii ◽  
The Difference ◽  
Early Local Recurrence ◽  
Male To Female

Objectives: Chondrosarcomas are rare tumors with a variable biological characteristic. Their treatment clinically and surgically is controversial. Analysis of the clinical statistics and prognostic factors of pelvic chondrosarcoma provides a reference for clinical diagnosis and treatment. Methods: A total of 73 cases of chondrosarcoma were collected, including 24 pelvic samples, from 2008 to 2017 from the hospital database and divided into two groups: pelvic chondrosarcoma and non-pelvic chondrosarcoma. The clinical characteristics and prognostic factors of pelvic chondrosarcoma were analyzed using different statistical methods. Results: Among the 24 pelvic chondrosarcoma patients, the ratio of male to female was 1.4:1, and the median age was 43.5 years. According to the classification proposed by Enneking, there were five grade I, 14 grade II, and five grade III. Histological grading of chondrosarcoma was grade I in one case, II in 15 cases, and III in eight cases. The histological type was 17 conventional, three dedifferentiated, two secondary, one myxoid, and one mesenchymal. The overall survival rates for 24 cases at three, five, and 10 years were 82.2±8.1%, 77.3±8.9%, and 52.4±12.1%, respectively. The local recurrence rate of pelvic chondrosarcoma after surgical resection (83.3%) was significantly higher than that of other sites (34.7%), and the difference was statistically significant (p < 0.001). The final proportion of amputation rate (50.0%) was also higher than other parts (20.4%), with a statistically significant difference (p =0.010). The total survival of the two groups was not significantly different (p =0.216). Conclusions: Chondrosarcoma of bone generally has an excellent prognosis when optimally diagnosed and treated by an experienced team of specialists. Pelvic chondrosarcoma has a higher local recurrence rate than the other sites and tends to result in amputation. Early local recurrence after surgery indicates a poor prognosis.

scholarly journals Surgical Resection for Small Cell Lung Cancer: Pneumonectomy versus Lobectomy

ISRN Surgery ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jiang Yuequan ◽  
Zhang Zhi ◽  
Xie Chenmin
Keyword(s):  
Overall Survival ◽  
Survival Rate ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Surgical Resection ◽  
Local Recurrence Rate ◽  
Overall Survival Rate ◽  
Significant Difference ◽  
The Right ◽  
Better Than

Background. There are some patients with SCLC that are diagnosed in the operating room by cryosection and surgeons had to perform surgical resection for these patients. The aim of this study is to compare the effective of pneumonectomy with lobectomy for SCLC. Methods. A retrospective study was undertaken in 75 patients with SCLC that were diagnosed by cryosection during surgery. 31 of them underwent pneumonectomy, 44 underwent lobectomy. Local recurrence rate and survival rate according to surgical procedures and cancer stages were analyzed. Results. There was significant difference in the overall survival rate between lobectomy and pneumonectomy groups (P=0.044). For patients with stage II SCLC, the overall survival rate after pneumonectomy was significantly better than after lobectomy (P=0.028). No significant difference in overall survival rate was found between the two surgical groups in patients with stage III SCLC (P=0.933). The local recurrence rate in lobectomy group was significant higher that in pneumonectomy group (P=0.0017). Conclusions. SCLC was responsive to surgical therapy. When surgeons have to select an appropriate method of operation for patients with SCLC during surgery, pneumonectomy may be the right choice for these patients. Pneumonectomy can result in significantly better local control and higher survival rate compare with lobectomy.

scholarly journals Security and Efficiency of Percutaneous Microwave Ablation using Combined Computed Tomography and Ultrasound-Guided Imaging in Patients with Hepatocellular Carcinoma: A Prospective Study

2020 ◽  
Author(s):  
Wenpeng Zhao ◽  
Jiang Guo ◽  
Honglu Li ◽  
Liang Cai ◽  
Youjia Duan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Microwave Ablation ◽  
Local Recurrence Rate ◽  
Treatment Time ◽  
Combination Group ◽  
Significant Difference ◽  
Percutaneous Microwave Ablation

Abstract Background: We prospectively evaluated the security and efficiency of percutaneous microwave ablation (MWA) using combined computed tomography (CT) and ultrasound (US)-guided imaging in patients with BCLC-A1-3 hepatocellular carcinoma (HCC) given that they have shortcomings when used alone.Methods: We included 88 consecutive patients with single HCC who were treated with transcatheter hepatic arterial chemoembolization (TACE). The patients were divided into 3 groups at random by using draw lots 1 week after TACE. The combination group (34 patients) received MWA under the guidance of CT and US, while the single group (CT group, 30 patients; US group, 24 patients) received MWA under the guidance of CT or US alone. Contrast-enhanced MRI or CT scans were performed in all patients 1, 3, 6 and 12 months after the procedure. The study endpoints included the treatment time, puncture time, local recurrence rate, and adverse events.Results: The median diameter of the lesions was 3.1 (1.5-4.2) cm. The median treatment time was 38.6 (30-45) min and 36.7 (30-47) min in the combination group and US group, respectively. The median puncture number was 1.2 (1-2) times and 1.1 (1-2) times, respectively. Both were significantly less than in the CT group (45.8 min and 4.2 times). The local recurrence rate was 5.9% in the combination group, which was significantly inferior to that in the US group (16.7%). The grade C complication rate in the combination group was 5.9%, while it was 13.3% and 8.3% in the CT group and US group, respectively. There was a statistically significant difference between the combination group and CT group.Conclusions: Using CT- and US-guided microwave ablation in patients with BCLC-A1-3 hepatocellular carcinoma appeared to be much better in terms of security and efficiency than the use of microwave ablation under the guidance of CT or US alone.

scholarly journals Safety and effectiveness of percutaneous microwave ablation using combined computed tomography and ultrasound-guided imaging in patients with hepatocellular carcinoma: A prospective study

2020 ◽  
Author(s):  
Wenpeng Zhao ◽  
Jiang Guo ◽  
Honglu Li ◽  
Liang Cai ◽  
Youjia Duan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Microwave Ablation ◽  
Local Recurrence Rate ◽  
Treatment Time ◽  
Combination Group ◽  
Significant Difference ◽  
Percutaneous Microwave Ablation

Abstract Background We prospectively evaluated the safety and effectiveness of percutaneous microwave ablation (MWA) using combined computed tomography (CT) and ultrasound (US)-guided imaging in patients with BCLC-A1-3 hepatocellular carcinoma (HCC) given that they have shortcomings when used alone. Methods We included 88 consecutive patients with single HCC who were treated with transcatheter hepatic arterial chemoembolization (TACE). The patients were divided into 3 groups at random by using draw lots 1 week after TACE. The combination group (34 patients) received MWA under the guidance of CT and US, while the single group (CT group, 30 patients; US group, 24 patients) received MWA under the guidance of CT or US alone. Contrast-enhanced MRI or CT scans were performed in all patients 1, 3, 6 and 12 months after the procedure. The study endpoints included the treatment time, puncture time, local recurrence rate, and adverse events. Results The median diameter of the lesions was 3.1 (1.5–4.2) cm. The median treatment time was 38.6 (30–45) min and 36.7 (30–47) min in the combination group and US group, respectively. The median puncture number was 1.2 (1–2) times and 1.1 (1–2) times, respectively. Both were significantly less than in the CT group (45.8 min and 4.2 times). The local recurrence rate was 5.9% in the combination group, which was significantly inferior to that in the US group (16.7%). The grade C complication rate in the combination group was 5.9%, while it was 13.3% and 8.3% in the CT group and US group, respectively. There was a statistically significant difference between the combination group and CT group. Conclusions Using CT- and US-guided microwave ablation in patients with BCLC-A1-3 hepatocellular carcinoma appeared to be much better in terms of security and efficiency than the use of microwave ablation under the guidance of CT or US alone.

scholarly journals Comparison of oncological safety between nipple sparing mastectomy and total mastectomy using propensity score matching

2015 ◽  
Vol 97 (4) ◽  
pp. 291-297 ◽  
Author(s):  
T Seki ◽  
H Jinno ◽  
K Okabayashi ◽  
T Murata ◽  
A Matsumoto ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Recurrence Rate ◽  
Local Recurrence Rate ◽  
Total Mastectomy ◽  
Oncological Safety ◽  
Significant Difference ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Introdcution Although nipple sparing mastectomy (NSM) has attracted increased recognition as an alternative to traditional mastectomy approaches, its oncological safety is unclear. The purpose of this study was to compare the local recurrence rate between NSM and total mastectomy (TM). Methods Between 2003 and 2013, 121 and 557 patients with stage 0–III breast cancer underwent NSM and TM respectively. Multivariate Cox regression and propensity score models were used to compare the two groups. Results There was no significant difference in the five-year local recurrence rate between the NSM and TM groups (7.6% vs 4.9%, p=0.398). In multivariate analysis, NSM was not a risk factor for local recurrence (hazard ratio: 1.653, 95% confidence interval: 0.586–4.663, p=0.343). Propensity score matching found similar five-year local recurrence free survival rates between the two groups (92.3% vs 93.7%, p=0.655). Conclusions Our results suggest that NSM may provide oncological safety comparable with mastectomy for carefully selected patients.

Re-excision of anterior margins for breast cancer is associated with a low local recurrence rate

2013 ◽  
Vol 39 (11) ◽  
pp. S66-S67
Author(s):  
Layal El-Asir ◽  
Faizan Jabbar ◽  
George Boundouki ◽  
Clive Griffith ◽  
James Harvey
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Local Recurrence Rate

scholarly journals Breast Cancer Survival Defined by Biological Receptor and Menopausal Status in Vietnamese Women

2019 ◽  
Vol 26 (1) ◽  
pp. 107327481986527 ◽  
Author(s):  
Thang Vu Hong ◽  
Duc Nguyen Ba ◽  
Lambert Skoog ◽  
Van Ta Thanh ◽  
Edneia Tani
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Survival Rate ◽  
Progesterone Receptor ◽  
Cox Model ◽  
Menopausal Status ◽  
Survival Rates ◽  
Factors Associated ◽  
Vietnamese Women ◽  
Significant Difference

Little is known about breast cancer in Vietnamese women. Previous studies have reported the frequencies of prognostic factors of breast cancer in this population. The aim of this study was to examine the prognostic factors associated with the survival rates of patients with breast cancer treated at the National Cancer Hospital, Hanoi, Vietnam. We recruited 248 women with operable breast cancer treated with surgery and adjuvant therapy. Tumor tissue samples were stained by many immunohistochemical approaches and analyzed for estrogen receptor, progesterone receptor, and HER2 gene amplification status. A Cox model was used to determine the relationship between survival and the prognostic factors. The disease-free survival rate, overall survival rate, and cancer-specific survival rate were 75.8%, 80.6%, and 86.4%, respectively, at 5 years and 62.3%, 68.1%, and 78.9%, respectively, at 10 years. The lung was the most common metastatic site. Women with factors associated with a poor prognosis (eg, advanced clinical stage, high tumor grade, progesterone receptor [PR] negativity, HER2 amplification) had significantly lower survival rates. Patients with PR-negative breast cancer had significantly worse survival rates compared to those who were PR positive, according to multivariate analysis (hazard ratio = 1.77, 95% confidence interval: 1.01-3.11, P = .045); however, there was only a statistically significant difference in postmenopausal patients. The PR was a prognostic factor in postmenopausal women with breast cancer, but not in premenopausal women.

Do pathological fractures influence survival and local recurrence rate in bony sarcomas?

2007 ◽  
Vol 43 (13) ◽  
pp. 1944-1951 ◽  
Author(s):  
J.A.M. Bramer ◽  
A.A. Abudu ◽  
R.J. Grimer ◽  
S.R. Carter ◽  
R.M. Tillman
Keyword(s):  
Local Recurrence ◽  
Recurrence Rate ◽  
Local Recurrence Rate ◽  
Pathological Fractures

scholarly journals ISR for T1-2 Low Rectal Cancer: A Japanese Approach

2020 ◽  
Vol 33 (06) ◽  
pp. 361-365
Author(s):  
Masaaki Ito
Keyword(s):  
Rectal Cancer ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Phase Ii ◽  
Local Recurrence Rate ◽  
Anal Verge ◽  
Low Rectal Cancer ◽  
Rectal Cancer Surgery ◽  
Rectal Cancers ◽  
Anal Preservation

AbstractThe evolution over the past 20 years of anal preservation in rectal cancer surgery has been truly remarkable. Intersphincteric resection (ISR) reported by Schiessel in 1994 in Australia has been shown to enable anal preservation even for cancers quite close to the anus. In Japan, ISR via the detachment of the anal canal between the internal and external sphincters and excision of the internal sphincter first began to be practiced in the latter half of 1990. A multicenter Phase II trial of ISR in Japan suggested that 70% of the cases had relatively good function with less than 10 points of Wexner score but around 10% had severe incontinence that would not be improved for long term. The primary end point of the clinical study, 3-year local recurrence rate, was 13.2% across the overall cohort (T1, 0%; T2, 6.9%; and T3, 21.6%). When ISR is performed on T1/T2 rectal cancers, sufficient circumferential resection margin can be obtained even without preoperative chemoradiotherapy, and local recurrence rate was acceptably low. Based on these evidences, ISR is a currently important, standard treatment option among anal-preserving surgeries for T1/T2 low-lying rectal cancers. In Japan, a feasibility study (LapRC trial) of laparoscopic ISR on Stage 0 and Stage 1 low rectal cancer showed excellent outcomes. A prospective Phase II clinical trial targeting low rectal cancers within 5 cm from the anal verge (ultimate trial) is being performed and awaiting the results in near future.

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