Central Giant Cell Granuloma of the Mandible: A Rare Presentation

2012 ◽  
Vol 3 (3) ◽  
pp. 172-174
Author(s):  
Sunita Malik ◽  
Virender Singh ◽  
Gurdarshan Singh ◽  
Nisha Dahiya
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Rare Presentation ◽  
Central Giant Cell Granuloma ◽  
Woven Bone ◽  
Local Trauma ◽  
Mandibular Body ◽  
Intraosseous Lesion ◽  
Age Range

ABSTRACT Central giant cell granuloma (CGCG) is an intraosseous lesion consisting of cellular fibrosis tissue that contains multiple foci of hemorrhage, multinucleated giant cells and trabeculas of woven bone. This lesion accounts for less than 7% of all benign jaw tumors. Jaffe considered it as a locally reparative reaction of bone which can be possibly due to either an inflammatory response, hemorrhage or local trauma. Females are affected more frequently than males. It occurs over a wide age range. It has been reported that this lesion is diagnosed during the first two decades of life in approximately 48% of cases and 60% of cases are evident before the age of 30. It is considerably more common in the mandible than in maxilla. The majority of the lesions occur in the molar and premolar area, and some of these extend to the ascending ramus. The presence of giant cell granuloma in the mandibular body area, entire ramus, condyle and coronoid creates a diagnostic and therapeutic challenge for the oral and maxillofacial surgeons. The purpose of this report is to describe an unusual presentation of CGCG involving mandibular body, ramus, condylar and coronoid processes and to discuss the differential diagnosis, radiographic presentation and management of this lesion. How to cite this article Malik S, Singh V, Singh G, Dahiya N. Central Giant Cell Granuloma of the Mandible: A Rare Presentation. Int J Head and Neck Surg 2012;3(3):172-174.

scholarly journals A UNIQUE CASE REPORT OF AGGRESSIVE CENTRAL GIANT CELL GRANULOMA OF THE MANDIBLE TREATED WITH CONSERVATIVE SURGICAL ENUCLEATION WITH LONG TERM FOLLOW-UP

2019 ◽  
Author(s):  
Gourab Das ◽  
Bharat Shukla ◽  
Dhritiman Pathak ◽  
Abhishek Singh ◽  
Shailesh Kumar
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Woven Bone ◽  
Long Term Follow Up ◽  
Benign Tumours ◽  
Bone Trabeculae ◽  
Surgical Aspects

Central Giant Cell Granuloma (CGCG) is an intrabony lesion showing cellular fibrosis with numerous foci of haemorrhage, woven bone trabeculae and multinucleated giant cells. It is more commonly found in the mandible than maxilla. Among all benign tumours of jaw, it accounts for less than 7%. According to the reports, in approximately 48% cases, it is diagnosed in the first two decades of life and in almost 60% cases, before 30 years of age. This paper presents a case of CGCG involving the mandibular left anterior region of a female patient with clinical, radiological, histopathological and surgical aspects of the lesion. Key Words- Central Giant Cell Granuloma (CGCG), CONSERVATIVE SURGICAL ENUCLEATION

scholarly journals Central Giant Cell Granuloma

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Nilotpol Kashyap ◽  
Manisha Upadhyay ◽  
Rupam Tripathi ◽  
Pallavi Pawar ◽  
Ranjeet Kumar Prasad Sah ◽  
...  
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Benign Tumours ◽  
Health Organization ◽  
Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

Central Giant Cell Granuloma: A Narrative Review of Radiological Features and Differential Diagnosis

2020 ◽  
Vol 3 (2) ◽  
pp. 01-05
Author(s):  
Cinzia Casu
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Genetic Syndromes ◽  
Radiographic Appearance ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones ◽  
Aneurysmal Bone Cysts ◽  
Intraosseous Lesion

The Central Giant Cell Granuloma is an uncommon lesion, accounting less than 7% of all benign jaw lesions. In 1953, Jaffe was the first to describe these lesions as a giant cell reparative granuloma of the jaw bones, and in 1971, thanks to Pindborg and Kramer, it was included in the current nomenclature. The aetiology of CGCG is unknown, there is also a peripheral type that some authors consider the most common in maxillary bones. WHO defines CGCG as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells, and some trabeculae of woven bone. The radiographic appearance of CGCGs is not pathognomonic. CGCGs should be differentiated from other lesions of the jaws such as Brown’s tumour of hyperparathyroidism, fibrous dysplasia, aneurysmal bone cysts, giant cell tumours, fibro-osseous lesions, and other malignancies that arise in the jaw bones. Furthermore, it needs to be differentiated even from some genetic syndromes, such as Cherubism, type 1-neurofibromatosis and Noonan’s syndrome. The aim of this study is to focus on radiographic features of CGCG in order to achieve an appropriate tool for diagnosis.

Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones

2016 ◽  
Vol 8 (2) ◽  
pp. e12214 ◽  
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Shailesh Gawande ◽  
Snehal Patil ◽  
Rahul Anand ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Long Bones ◽  
Giant Cell Granuloma ◽  
Giant Cell Tumors ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones

Central giant cell granuloma of the mandibular condyle: A rare presentation

2002 ◽  
Vol 60 (8) ◽  
pp. 939-941 ◽  
Author(s):  
Imad Abu-El-Naaj ◽  
Leon Ardekian ◽  
Ronit Liberman ◽  
Micha Peled
Keyword(s):  
Giant Cell ◽  
Mandibular Condyle ◽  
Giant Cell Granuloma ◽  
Rare Presentation ◽  
Central Giant Cell Granuloma

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

2022 ◽  
Author(s):  
Monir Moradzadeh Khiavi ◽  
Abbas Karimi ◽  
Hassan Mirmohammad Sadeghi ◽  
Samira Derakhshan ◽  
Seyed Mobin Tafreshi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Benign Lesion ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.  

Giant Cell Reparative Granuloma (Central) of Maxilla: Case Report and Review

2010 ◽  
Vol 3 (3) ◽  
pp. 177-180 ◽  
Author(s):  
SS Bist ◽  
Saurabh Varshney ◽  
Kranti Bhavna
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Giant Cell Reparative Granuloma ◽  
Root Tips ◽  
Central Giant Cell Granuloma ◽  
Neoplastic Lesion ◽  
Multilocular Radiolucency ◽  
Unerupted Teeth ◽  
Intraosseous Lesion

Abstract Term Giant Cell Reparative Granuloma (GCRG) a non-neoplastic lesion characterized by a proliferation of granulation tissue containing numerous multinucleated giant cells was introduced by Jaffe in 1953 to describe an apparently reactive intraosseous lesion of the mandible and maxilla following trauma induced intraosseous hemorrhage. It is a disease of the young presenting as a painless swelling in the anterior jaw. It appears on radiology as a unilocular or multilocular radiolucency with a characteristic tendency of resorbing the root tips of adjacent unerupted teeth. A central giant cell granuloma of the maxilla is presented, which was diagnosed in a seventeen-year-old male and surgically treated.

scholarly journals Central Giant Cell Granuloma of The Maxilla: Case Report and Literature Review

2021 ◽  
pp. 1-3
Author(s):  
Aicha Ibourk ◽  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Giant Cell ◽  
Fibrous Tissue ◽  
Surgical Removal ◽  
Brown Tumor ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
The Right ◽  
Intraosseous Lesion

Introduction: Central giant cell granuloma (CGCG) is a rare bony lesion in the Head and Neck region. It is a non-odontogenic tumor never seen in any other bone of the skeleton. It is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone. Case Report: We report a case of a 50-year-old female patient with swelling on the right side of face for 4 months. Intraoral examination shows a mass in right lower jaw in the region of 45 and 46 edentulous areas. The swelling had smooth surface, firm and tender on palpation. There was no expansion of lingual region. The radiological examination revealed a well-defined multiloculated expansile and lytic lesion in the right mandible, extending from the 44 to 47 with a resorption of teeth 44. The patient underwent incisional biopsy and the diagnosis of CGCG and brown tumor of hyperparathyroidism was proposed. According to the clinical radiological and biological findings, the diagnosis of CGCG was confirmed. The enucleation of the lesion with the extraction of 44 was done. Discussion: Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the head and neck with potential for aggressive and locally destructive behaviour. Lesions of the maxilla tend to expand more than those of the mandible due to the thinner cortices and spongy tissue of this location. Surgical removal is the most common treatment; however, it may be disfiguring in aggressive cases, especially for lesions located in the maxilla. Alternative treatments, such as intralesional corticosteroid injections, have been performed with satisfactory results.

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