Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.

Peripheral Odontogenic Fibroma- Case Series of a Rare Benign Tumor

Peripheral odontogenic fibroma (POdF) is a rare benign odontogenic tumor of ectomesenchymal origin which is composed of fibrous connective tissue containing islands, strands or cords of odontogenic epithelium. The lesion is more common among females, commonly seen between the second to fourth decades of life, mostly affecting the anterior region of mandible. Clinically, it may present similar characteristics with other more common gingival lesions such as pyogenic granuloma, peripheral ossifying fibroma and peripheral giant cell granuloma. So, histopathological examination is required for accurate diagnosis. We present here three rare clinical cases of peripheral odontogenic fibroma and their management by complete excision of the lesion with good postoperative outcomes.

Extraosseous odontogenic fibroma with a clear cells component: a 5-year follow-up

The extraosseous/peripheral odontogenic fibroma (E/POF) is a benign mesenchymal odontogenic tumour found on the gingival surface with clinical characteristics identical to those of reactive lesions. A histopathological analysis is the only method for determining the difference between reactive lesions and these neoplastic lesions, whose recurrence potential varies between 38.9% and 50%, highlighting the importance of correct diagnosis. The following report describes an E/POF case with a clear cells component, as well as a long-term follow-up treatment, which we emphasise due to its potential for recurrence.

PERIPHERAL ODONTOGENIC FIBROMA: MIMICKING GINGIVAL SQUAMOUS CELL CARCINOMA: A RARE CASE REPORT AND REVIEW OF LITERATURE

In neoplasms Peripheral Odontogenic Tumors(POT) are one of the rare to occur on gingiva, among them, Peripheral Odontogenic Fibroma (POdF) is the most common. A plethora of lesions sharing similar clinical features, makes the diagnosis difcult. POdF is a benign, slow-growing, smooth, exophytic, painless lesion but it may show diverse clinical presentation as erythematous, lobulated, rapidly growing mass which might be tender on palpation overlapping the features with various inammatory gingival conditions to even a gingival squamous cell carcinoma.This results into diagnostic enigma. Histopathologoical examination plays a vital role in these type of cases. Discussed here is a case of POdF mimicking gingival squamous cell carcinoma. Histopathological investigation showed presence of odontogenic epithelium and dystrophic calcication which are the pathognomonic features of POdF. After surgical removal,POdF is seen to recur but, the exact recurrence rate cannot be estimated due to scarcity of reported cases.