A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

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Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma

F1000Research ◽

10.12688/f1000research.19891.1 ◽

2019 ◽

Vol 8 ◽

pp. 1218

Author(s):

Hadeer Rizk Saad ◽

Noura M. Kamal ◽

Hatem W. Amer

Keyword(s):

Connective Tissue ◽

Giant Cell ◽

Bone Lesion ◽

Giant Cells ◽

World Health ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Juvenile Ossifying Fibroma

Central giant cell granuloma (CGCG) is classified by the World Health Organization as a benign bone lesion. It is found anteriorly in the mandible, with most of the cases crossing the midline. In total, 70% of CGCGs are encountered in young females. Fibro-osseous lesions are a group of pathologies that encompass neoplastic, dysplastic and reactive entities. Juvenile ossifying fibroma, which can be further categorized into juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma, represents an aggressive neoplastic example of these fibro-osseous lesions. JTOF occurs in children at almost equal ratios in both sexes, affecting the maxilla more than mandible. This study aims to report a peculiar case of a hybrid lesion comprising CGCG and JTOF in the mandible of a nine-year-old female patient. Clinical, radiographic and histopathological findings were assessed. Clinical examination revealed an intraoral swelling extending from the right impacted third molar area to the left first molar area. Computed tomography showed a well-defined multilocular radiolucency with diffuse flecks of radioopacities. Histopathologically, the lesion comprised fibrous connective tissue encompassing numerous multinucleated giant cells and other areas of cell-rich connective tissue stroma containing bands of osteoid matrix and anastomosing immature bone trabeculae intermixed with scattered clusters of multinucleated giant cells. We hereby report a case of a rare hybrid lesion comprising CGCG and JTOF.

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Central Giant Cell Granuloma

Dentistry and Oral Maxillofacial Surgery ◽

10.31579/2643-6612/010 ◽

2019 ◽

Vol 2 (1) ◽

pp. 01-04

Author(s):

Nilotpol Kashyap ◽

Manisha Upadhyay ◽

Rupam Tripathi ◽

Pallavi Pawar ◽

Ranjeet Kumar Prasad Sah ◽

...

Keyword(s):

Giant Cell ◽

Fibrous Tissue ◽

Giant Cells ◽

World Health ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Bony Lesion ◽

Benign Tumours ◽

Health Organization ◽

Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

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Aggressive Central Giant Cell Granuloma in the Posterior Region of Mandible – A Case Report

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210416 ◽

2021 ◽

Vol 11 (4) ◽

pp. 118-121

Author(s):

Ajay Sutare ◽

Ajay Pratap Singh Parihar ◽

Varsha A.C.

Keyword(s):

Case Report ◽

Key Words ◽

Giant Cell ◽

Root Resorption ◽

Osteolytic Lesion ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Mandibular Molar ◽

Bony Lesion ◽

Molar Region

Central giant cell granuloma (CGCG) is an uncommon, benign, intraosseous bony lesion of the mandible and maxilla which is variably aggressive in nature. The incidence of an aggressive and recurrence nature is greatest in a female with a ratio of 2:1. Based on the clinical and radiographic features, Central giant cell granuloma can be classified as aggressive and non-aggressive lesions. Here we report a case of central giant cell granuloma in the posterior mandibular molar region which was aggressive in nature. The clinically and radiographically swelling was evaluated with displaced tooth, pain, cortical expansion, and root resorption. The treatment varies according to the nature of the lesion, this case was treated by conservative excision with continuity of the mandible. Key words: Aggressive, central giant cell granuloma, osteolytic lesion.

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Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Frontiers in Dentistry ◽

10.18502/fid.v18i44.8340 ◽

2022 ◽

Author(s):

Monir Moradzadeh Khiavi ◽

Abbas Karimi ◽

Hassan Mirmohammad Sadeghi ◽

Samira Derakhshan ◽

Seyed Mobin Tafreshi ◽

...

Keyword(s):

Giant Cell ◽

Benign Lesion ◽

Excisional Biopsy ◽

Giant Cells ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Odontogenic Fibroma ◽

Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.

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A Conservative Surgical Approach Towards Central Giant Cell Granuloma: A Case Report

Journal of the Bahrain Medical Society ◽

10.26715/jbms.3_18112018 ◽

2018 ◽

Vol 30 (3) ◽

pp. 1-4

Author(s):

Ahmed Al-Qattan

Keyword(s):

Case Report ◽

Giant Cell ◽

Surgical Approach ◽

Pyogenic Granuloma ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Case Presentation ◽

Central Giant Cell Granuloma ◽

History Of ◽

Bony Lesion

Central giant cell granuloma (CGCG) is an infrequent benign bony lesion of unpredictably aggressive behavior. The precise lesion character is debatable and remains inconclusive. However, three main theories were proposed: a sensitive lesion, a kind of neoplasm, or a developmental anomaly. This is a case presentation of a 16-year-old boy with a dental history of extraction of the lower right first molar, presented to hospital with two months history of swelling in the aforementioned area after the procedure. First biopsy of the swelling was performed outside the Kingdom of Bahrain. As per histopathological findings, the swelling was described as pyogenic granuloma. Second biopsy with necessary workup was conducted in the Kingdom of Bahrain and was confirmed as central giant cell granuloma through histopathological analysis; it was removed surgically.

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Collision Lesion of Mandible—Coexistence of Keratocystic Odontogenic Tumor with Central Giant Cell Granuloma: A Rare Case Report

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1327 ◽

2013 ◽

Vol 14 (2) ◽

pp. 355-359 ◽

Cited By ~ 1

Author(s):

C Prashanthi ◽

Vinayak Karun ◽

Mahesh Melkundi ◽

Sanjay Nyamati ◽

Annapoorna HB

Keyword(s):

Case Report ◽

Giant Cell ◽

Rare Case ◽

Giant Cells ◽

Odontogenic Tumor ◽

Biological Behavior ◽

Keratocystic Odontogenic Tumor ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Rare Case Report

ABSTRACT Aim and background An odontogenic keratocyst (OKC) or keratocystic odontogenic tumor (KCOT) and giant cell granuloma (GCG) in the jaws are common lesions which have been studied extensively in detail over the years. However, a lesion showing features of both is exceptionally rare and is reported only twice in the literature till date. Case description A rare case of OKC in mandible showing foci of GCG like areas is reported in a 29 years old male patient. Conclusion It seems to be a collision lesion, though the possibility of KCOT showing a reactive response to form giant cells or it being a rare variant cannot be totally ruled out. Clinical significance This entity requires aggressive treatment since biological behavior of this unique lesion is difficult to predict unless more of such lesions are reported and followed up in future. How to cite this article Ravi SB, Prashanthi C, Karun V, Melkundi M, Nyamati S, Annapoorna HB. Collision Lesion of Mandible: Coexistence of Keratocystic Odontogenic Tumor with Central Giant Cell Granuloma: A Rare Case Report. J Contemp Dent Pract 2013;14(2):355-359.

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