Central Giant Cell Granuloma

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

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Central Giant Cell Granuloma: A Narrative Review of Radiological Features and Differential Diagnosis

General medicine and Clinical Practice ◽

10.31579/2639-4162/030 ◽

2020 ◽

Vol 3 (2) ◽

pp. 01-05

Author(s):

Cinzia Casu

Keyword(s):

Giant Cell ◽

Fibrous Tissue ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Genetic Syndromes ◽

Radiographic Appearance ◽

Central Giant Cell Granuloma ◽

Jaw Bones ◽

Aneurysmal Bone Cysts ◽

Intraosseous Lesion

The Central Giant Cell Granuloma is an uncommon lesion, accounting less than 7% of all benign jaw lesions. In 1953, Jaffe was the first to describe these lesions as a giant cell reparative granuloma of the jaw bones, and in 1971, thanks to Pindborg and Kramer, it was included in the current nomenclature. The aetiology of CGCG is unknown, there is also a peripheral type that some authors consider the most common in maxillary bones. WHO defines CGCG as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells, and some trabeculae of woven bone. The radiographic appearance of CGCGs is not pathognomonic. CGCGs should be differentiated from other lesions of the jaws such as Brown’s tumour of hyperparathyroidism, fibrous dysplasia, aneurysmal bone cysts, giant cell tumours, fibro-osseous lesions, and other malignancies that arise in the jaw bones. Furthermore, it needs to be differentiated even from some genetic syndromes, such as Cherubism, type 1-neurofibromatosis and Noonan’s syndrome. The aim of this study is to focus on radiographic features of CGCG in order to achieve an appropriate tool for diagnosis.

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Extensive Aggressive Central Giant Cell Granuloma of the Mandible: Conservative Steroids Treatment in a Pediatric Patient

Craniomaxillofacial Trauma & Reconstruction Open ◽

10.1055/s-0037-1601482 ◽

2017 ◽

Vol 1 (1) ◽

pp. s-0037-1601482

Author(s):

Pietro Boni ◽

Alberto Bozzetti ◽

Valeria Morganti ◽

Giorgio Novelli ◽

Davide Sozzi

Keyword(s):

Giant Cell ◽

Pediatric Patient ◽

Corticosteroid Injection ◽

Fibrous Tissue ◽

Treatment Protocol ◽

World Health ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Intralesional Corticosteroid ◽

Health Organization

Central giant cell granuloma (CGCG) is a relatively rare intraosseous lesion, described by the World Health Organization as a localized proliferation consisting of fibrous tissue with hemorrhage deposits, the presence of osteoclast-like cells, and reactive bone formation. In this article, the authors present their experience in managing a wide, aggressive CGCG of the whole tooth-bearing mandible in a 9-year-old pediatric patient. The extension of the lesion and the age of the patient have presented a double challenge concerning treatment and outcome. If fact the main objective remains a correct therapeutic treatment, focused on healing the patient and avoiding recurrences, the clinician must be careful in preventing an excessive morbidity. The authors decided to treat the young patient with intralesional corticosteroid therapy, reserving surgery in case of non-response or for subsequent refinements. In this article is presented the authors’ conservative treatment protocol with intralesional corticosteroid injection and their results are compared with literature's data.

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Multiple peripheral odontogenic fibroma, world health organization type, and central giant cell granuloma: A case report of an unusual association

Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0278-2391(10)80186-7 ◽

1993 ◽

Vol 51 (3) ◽

pp. 325-328 ◽

Cited By ~ 25

Author(s):

Giuseppe Ficarra ◽

J. Philip Sapp ◽

Lewis R. Eversole

Keyword(s):

Case Report ◽

World Health Organization ◽

Giant Cell ◽

World Health ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Unusual Association ◽

Odontogenic Fibroma ◽

Health Organization

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A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

IP Journal of Diagnostic Pathology and Oncology ◽

10.18231/j.jdpo.2021.034 ◽

2021 ◽

Vol 6 (2) ◽

pp. 155-158

Author(s):

Rohini Sebastian ◽

Meethu Rappai

Keyword(s):

Case Report ◽

Connective Tissue ◽

Parathyroid Adenoma ◽

Giant Cell ◽

Stromal Cells ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

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A UNIQUE CASE REPORT OF AGGRESSIVE CENTRAL GIANT CELL GRANULOMA OF THE MANDIBLE TREATED WITH CONSERVATIVE SURGICAL ENUCLEATION WITH LONG TERM FOLLOW-UP

Clinical Dentistry ◽

10.33882/clinicaldent.13.25366 ◽

2019 ◽

Author(s):

Gourab Das ◽

Bharat Shukla ◽

Dhritiman Pathak ◽

Abhishek Singh ◽

Shailesh Kumar

Keyword(s):

Giant Cell ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Woven Bone ◽

Long Term Follow Up ◽

Benign Tumours ◽

Bone Trabeculae ◽

Surgical Aspects

Central Giant Cell Granuloma (CGCG) is an intrabony lesion showing cellular fibrosis with numerous foci of haemorrhage, woven bone trabeculae and multinucleated giant cells. It is more commonly found in the mandible than maxilla. Among all benign tumours of jaw, it accounts for less than 7%. According to the reports, in approximately 48% cases, it is diagnosed in the first two decades of life and in almost 60% cases, before 30 years of age. This paper presents a case of CGCG involving the mandibular left anterior region of a female patient with clinical, radiological, histopathological and surgical aspects of the lesion. Key Words- Central Giant Cell Granuloma (CGCG), CONSERVATIVE SURGICAL ENUCLEATION

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Central Giant Cell Granuloma of the Mandible: A Rare Presentation

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1122 ◽

2012 ◽

Vol 3 (3) ◽

pp. 172-174

Author(s):

Sunita Malik ◽

Virender Singh ◽

Gurdarshan Singh ◽

Nisha Dahiya

Keyword(s):

Giant Cell ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Rare Presentation ◽

Central Giant Cell Granuloma ◽

Woven Bone ◽

Local Trauma ◽

Mandibular Body ◽

Intraosseous Lesion ◽

Age Range

ABSTRACT Central giant cell granuloma (CGCG) is an intraosseous lesion consisting of cellular fibrosis tissue that contains multiple foci of hemorrhage, multinucleated giant cells and trabeculas of woven bone. This lesion accounts for less than 7% of all benign jaw tumors. Jaffe considered it as a locally reparative reaction of bone which can be possibly due to either an inflammatory response, hemorrhage or local trauma. Females are affected more frequently than males. It occurs over a wide age range. It has been reported that this lesion is diagnosed during the first two decades of life in approximately 48% of cases and 60% of cases are evident before the age of 30. It is considerably more common in the mandible than in maxilla. The majority of the lesions occur in the molar and premolar area, and some of these extend to the ascending ramus. The presence of giant cell granuloma in the mandibular body area, entire ramus, condyle and coronoid creates a diagnostic and therapeutic challenge for the oral and maxillofacial surgeons. The purpose of this report is to describe an unusual presentation of CGCG involving mandibular body, ramus, condylar and coronoid processes and to discuss the differential diagnosis, radiographic presentation and management of this lesion. How to cite this article Malik S, Singh V, Singh G, Dahiya N. Central Giant Cell Granuloma of the Mandible: A Rare Presentation. Int J Head and Neck Surg 2012;3(3):172-174.

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Central Giant Cell Granuloma of The Maxilla: Case Report and Literature Review

10.47363/jdsr/2021(3)114 ◽

2021 ◽

pp. 1-3

Author(s):

Aicha Ibourk ◽

Keyword(s):

Case Report ◽

Head And Neck ◽

Giant Cell ◽

Fibrous Tissue ◽

Surgical Removal ◽

Brown Tumor ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

The Right ◽

Intraosseous Lesion

Introduction: Central giant cell granuloma (CGCG) is a rare bony lesion in the Head and Neck region. It is a non-odontogenic tumor never seen in any other bone of the skeleton. It is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone. Case Report: We report a case of a 50-year-old female patient with swelling on the right side of face for 4 months. Intraoral examination shows a mass in right lower jaw in the region of 45 and 46 edentulous areas. The swelling had smooth surface, firm and tender on palpation. There was no expansion of lingual region. The radiological examination revealed a well-defined multiloculated expansile and lytic lesion in the right mandible, extending from the 44 to 47 with a resorption of teeth 44. The patient underwent incisional biopsy and the diagnosis of CGCG and brown tumor of hyperparathyroidism was proposed. According to the clinical radiological and biological findings, the diagnosis of CGCG was confirmed. The enucleation of the lesion with the extraction of 44 was done. Discussion: Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the head and neck with potential for aggressive and locally destructive behaviour. Lesions of the maxilla tend to expand more than those of the mandible due to the thinner cortices and spongy tissue of this location. Surgical removal is the most common treatment; however, it may be disfiguring in aggressive cases, especially for lesions located in the maxilla. Alternative treatments, such as intralesional corticosteroid injections, have been performed with satisfactory results.

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Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma

F1000Research ◽

10.12688/f1000research.19891.1 ◽

2019 ◽

Vol 8 ◽

pp. 1218

Author(s):

Hadeer Rizk Saad ◽

Noura M. Kamal ◽

Hatem W. Amer

Keyword(s):

Connective Tissue ◽

Giant Cell ◽

Bone Lesion ◽

Giant Cells ◽

World Health ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Juvenile Ossifying Fibroma

Central giant cell granuloma (CGCG) is classified by the World Health Organization as a benign bone lesion. It is found anteriorly in the mandible, with most of the cases crossing the midline. In total, 70% of CGCGs are encountered in young females. Fibro-osseous lesions are a group of pathologies that encompass neoplastic, dysplastic and reactive entities. Juvenile ossifying fibroma, which can be further categorized into juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma, represents an aggressive neoplastic example of these fibro-osseous lesions. JTOF occurs in children at almost equal ratios in both sexes, affecting the maxilla more than mandible. This study aims to report a peculiar case of a hybrid lesion comprising CGCG and JTOF in the mandible of a nine-year-old female patient. Clinical, radiographic and histopathological findings were assessed. Clinical examination revealed an intraoral swelling extending from the right impacted third molar area to the left first molar area. Computed tomography showed a well-defined multilocular radiolucency with diffuse flecks of radioopacities. Histopathologically, the lesion comprised fibrous connective tissue encompassing numerous multinucleated giant cells and other areas of cell-rich connective tissue stroma containing bands of osteoid matrix and anastomosing immature bone trabeculae intermixed with scattered clusters of multinucleated giant cells. We hereby report a case of a rare hybrid lesion comprising CGCG and JTOF.

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Giant Cell Urothelial Carcinoma of Bladder

Case Reports in Urology ◽

10.1155/2021/8021947 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Harshima Disvini Wijesinghe ◽

Ajith Malalasekera

Keyword(s):

Urothelial Carcinoma ◽

Giant Cell ◽

Early Stage ◽

Giant Cells ◽

World Health ◽

World Health Organization Classification ◽

Health Organization

Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic giant cells. We discuss a case of giant cell urothelial carcinoma presenting at an early stage in a previously well 62-year-old woman. Histology showed a tumour comprising pancytokeratin positive bizarre mononuclear and multi-nuclear giant cells admixed with areas of conventional urothelial carcinoma and carcinoma in situ. Three-month follow-up cystoscopy and magnetic resonance imaging showed no evidence of recurrence or pelvic lymphadenopathy.

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