Role of Color Doppler Ultrasonography in Differentiation of Graves’ Disease from Thyroiditis: A Prospective Study

ABSTRACT Introduction Thyrotoxicosis due to Graves’ disease (GD) and destructive thyroiditis (DT) needs differentiation, as management strategy differs. Factors that help in diagnosis are biochemical and nuclear imaging. Utility of high-resolution ultrasonography (HRUSG) and color Doppler (CD) in differentiation is not widely practiced. We undertook the prospective study in the Department of Endocrine Surgery at a tertiary care center among South Indian population in 1 year as a cost-effective model Materials and methods Out of 120 newly diagnosed thyrotoxicosis patients, 54 were GD (group I) and 66 were DT (group II) patients. Totally, 55 euthyroid patients served as controls. Parameters analyzed were demography, free thyroid function test (TFT) anti-thyroid-stimulating hormone receptor antibody (TSHrAB), antithyroid peroxidase antibody (ATPO), anti-thyroglobulin antibody (ATG), and Tc-99m thyroid scintigraphy. Parameters analyzed using HRUSG and CD were peak systolic velocity (PSV), end-diastolic volume (EDV), pulsatility index (PI), resistive index (RI) of bilateral superior thyroid artery (STA) and inferior thyroid artery (ITA). Results Both groups were age and sex matched. The TFT, ATPO, and ATG were comparable between both groups (p = 0.609). The TSHrAB (IU/mL) was significantly higher in group I (36.11 ± 0.82) than group II (1.23 ± 0.24) (p < 0.001). Mean thyroid volume (mL) was higher in group I (28.9 ± 14.9) than group II (26.2 ± 8.81) (p = 0.022). Mean PSV-STA (cm/s) was statistically higher in group I (54.09 ± 4.67) than group II (28.92 ± 4.39) (p ≤ 0.001). Mean PSV-ITA (cm/s) was higher in group I (32.11 ± 2.45) than group II (25.23 ± 3.45) (p = 0.006). Other parameters measured in both arteries like mean EDV (cm/s), mean RI, and mean PI were comparable between both groups. Conclusion The HRUSG with CD evaluation of PSV STA and ITA is a cost-effective alternative to TSHrAB and thyroid scintigraphy in differentiating GD from DT patients. Additionally, we observed that PSV in STA was higher than in ITA in patients with GD. To conclude, HRUSG and CD are simple, cost-effective, and widely available tools in the differentiation of GD from DT. How to cite this article Sundarram KST, Sadacharan D, Ravikumar K, Kalpana S, Suresh RV. Role of Color Doppler Ultrasonography in Differentiation of Graves’ Disease from Thyroiditis: A Prospective Study. World J Endoc Surg 2017;9(2):41-45.

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Predicting Malignancy in a Solitary Thyroid Nodule: A Prospective Study on the Role of Color Doppler Ultrasonography

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/jp-journals-10003-1144 ◽

2014 ◽

Vol 6 (1) ◽

pp. 9-14 ◽

Cited By ~ 1

Author(s):

Ravi Varma ◽

Gururaja Rao ◽

Shilpa Rao ◽

Nikhil M Bhagwat ◽

Manoj D Chadha ◽

...

Keyword(s):

Prospective Study ◽

Thyroid Nodule ◽

Doppler Ultrasonography ◽

Thyroid Nodules ◽

Color Doppler ◽

Color Doppler Ultrasonography ◽

Solitary Thyroid Nodule ◽

A Prospective Study ◽

Central Flow

ABSTRACT Palpable thyroid nodules are fairly common. While many are benign, the clinician faces the challenge of detecting the 4 to 14% of malignant lesions. Fine needle aspiration cytology (FNAC) of thyroid nodules seems to have eclipsed all other techniques for diagnosis of thyroid cancer, but has its limitations when a nodule is inaccessible or in the case of follicular neoplasm. This study from a hospital from Indian west coast shows that vascular flow pattern of extensive peripheral and central flow (Type-3) or a central flow only (Type-4) and a resistive index (RI) of >0.75 on power Doppler sonography shows a healthy sensitivity and excellent specificity for predicting malignancy. The utility becomes even more apparent among follicular neoplasms where FNAC can offer little help in distinguishing malignancy. How to cite this article Rao G, Rao S, Varma R, Bhagwat NM, Chadha MD, Joshi AS, Varthakavi PK. Predicting Malignancy in a Solitary Thyroid Nodule: A Prospective Study on the Role of Color Doppler Ultrasonography. Int J Otorhinolaryngol Clin 2014;6(1):9-14.

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INCIDENCE OF TEMPORAL ARTERITIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: A PROSPECTIVE STUDY USING COLOR DOPPLER ULTRASONOGRAPHY OF THE TEMPORAL ARTERIES

Ultrasound Quarterly ◽

10.1097/00013644-200209000-00017 ◽

2002 ◽

Vol 18 (3) ◽

pp. 214

Author(s):

&NA;

Keyword(s):

Prospective Study ◽

Polymyalgia Rheumatica ◽

Doppler Ultrasonography ◽

Temporal Arteritis ◽

Color Doppler ◽

Color Doppler Ultrasonography ◽

Temporal Arteries ◽

A Prospective Study

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Value of color Doppler ultrasonography and radiography for the assessment of the cancellous bone scaffold coated with nano-hydroxyapatite in repair of radial bone in rabbit

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502012000200009 ◽

2012 ◽

Vol 27 (2) ◽

pp. 148-154 ◽

Cited By ~ 2

Author(s):

Rasoul Rahimzadeh ◽

Abbas Veshkini ◽

Davood Sharifi ◽

Saeed Hesaraki

Keyword(s):

Bone Defect ◽

Cancellous Bone ◽

Doppler Ultrasonography ◽

Local Reaction ◽

Proper Time ◽

Color Doppler ◽

Color Doppler Ultrasonography ◽

Bone Scaffold ◽

Group I ◽

Group Ii

PURPOSE: To evaluate the osteo-regenerative capacity of proprietary bone grafting material as a bone defect filler and osteogenetic stimulation to speed up bone healing too. METHODS: Eighteen adult male New Zealand white rabbits were anesthetized and a segmental full thickness bone defect of 10 mm in length was created in the middle of the right radial shaft in all rabbits. They were divided into two groups of 9 rabbits. Group I was considered as control and the fractured site was fixed using finger bone plate with 4 screws, whereas the cancellous bone scaffold coated with Nano-Hydroxyapatite was used to fill the gap after fracture fixation in Group II. Radiography, two dimensional and color Doppler ultrasonography were done before and after creating defects and on 0, 15, 30, 60 and 90 days to evaluate local reaction as far as new blood vessels network and callus formation are observed. RESULTS: On the radiographs during the whole process, bone repair in Group I was not as perfect as those in Group II samples and trace of internal callus filled the gap incompletely in 60 days in Group I, whereas in Group II internal callus almost was formed on 30 days and in addition intercortical callus was seen supporting to cover and filled the gap completely in this group in 60 day; Sonographic findings confirmed the protrusion of newly formed blood vascular network in 30 days in Group I and from 15 days in Group II and remarkably increased till end of observation period. CONCLUSIONS: The nano-hydroxyapatite with more features and shorter in time, made possible the reconstruction of bone tissue and alternative techniques as well as previous bone graft, also radiography and ultrasonography are reliable techniques to trace local reaction at proper time.

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