Cord Blood Neutrophil Phagocytic Index in Neonates Born to Anemic Mothers and in Neonates Born with Risk of Early-onset Sepsis

Introduction: Sepsis remains one of the most common causes of neonatal mortality and morbidity in India as also globally. Aim:To evaluate the level of procalcitonin (PCT) in the cord blood of the neonates born with perinatal risk factors for early-onset sepsis (EOS) at a tertiary referral hospital of Kolkata. Materials and methods: st An observational cross-sectional study Labour room of R G Kar Medical College & Hospital, Kolkata From February 1 , st 2019 to July 31 , 2020. Conclusion: This practice would represent a reduction of the potential toxicity in the newborns and in the development of bacterial resistances as well. However, maternal prophylactic antibiotherapy decreases the incidences of vertically transmitted neonatal infections

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Study of umbilical cord blood culture in diagnosis of early-onset sepsis among newborns with high-risk factors

Journal of Clinical Neonatology ◽

10.4103/2249-4847.123092 ◽

2013 ◽

Vol 2 (4) ◽

pp. 169 ◽

Cited By ~ 6

Author(s):

MitulBabubhai Kalathia ◽

IlaMitulkumar Kalathia ◽

PrakashAshokbhai Shingala ◽

ParinNiranjanbhai Parmar ◽

YogeshNarenedrabhai Parikh

Keyword(s):

Risk Factors ◽

High Risk ◽

Blood Culture ◽

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Early Onset ◽

High Risk Factors ◽

Early Onset Sepsis

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Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis

Frontiers in Pediatrics ◽

10.3389/fped.2021.794710 ◽

2021 ◽

Vol 9 ◽

Author(s):

Vilmaris Quinones Cardona ◽

Vanessa Lowery ◽

David Cooperberg ◽

Endla K. Anday ◽

Alison J. Carey

Keyword(s):

Quality Improvement ◽

Blood Culture ◽

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Peripheral Blood ◽

Early Onset ◽

Clinical Sepsis ◽

Early Onset Sepsis ◽

Antibiotic Duration

Introduction: Despite the advantages of umbilical cord blood culture (UCBC) use for diagnosis of early onset sepsis (EOS), contamination rates have deterred neonatologists from its widespread use. We aimed to implement UCBC collection in a level III neonatal intensive care unit (NICU) and apply quality improvement (QI) methods to reduce contamination in the diagnosis of early onset sepsis.Methods: Single-center implementation study utilizing quality improvement methodology to achieve 0% contamination rate in UCBC samples using the Plan-Do-Study-Act (PDSA) model for improvement. UCBC was obtained in conjunction with peripheral blood cultures (PBC) in neonates admitted to the NICU due to maternal chorioamnionitis. Maternal and neonatal characteristics between clinical sepsis and asymptomatic groups were compared. Process, outcome, and balancing measures were monitored.Results: Eighty-two UCBC samples were collected in addition to peripheral blood culture from neonates admitted due to maternal chorioamnionitis. Ten (12%) neonates had a diagnosis of clinical sepsis. All PBCs were negative and 5 UCBCs were positive in the study period. After 2 PDSA cycles, there was special cause variation with improvement in the percent of contaminated samples from 7.3 to 0%. There was no change in antibiotic duration among asymptomatic neonates.Conclusions: Implementation of UCBC for the diagnosis of EOS in term infants is feasible and contamination can be minimized with the implementation of a core team of trained providers and a proper sterile technique without increasing antibiotic duration.

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