Cord blood interleukin-6 as a predictor of early-onset sepsis in preterm babies

Use of empirical antibiotics in neonates with risk factors of early-onset neonatal sepsis (EOS) is a common practice. A laboratory parameter is needed to help in the accurate diagnosis of EOS to avoid unnecessary use of antibiotics. The aim of this prospective observational cohort study was to compare the statistical validity of cord blood interleukin-6 (IL-6) with conventional sepsis screening as an early diagnostic marker for EOS. Eighty-seven neonates with antenatal risk factors for sepsis were followed up for 72 h for the development of EOS. Cord blood was collected for measurement of IL-6 concentrations. Blood culture and conventional sepsis screening (total leukocyte count, absolute neutrophil count, C-reactive protein and micro-erythrocyte sedimentation rate) were sent for analysis soon after delivery. The study group comprised of symptomatic neonates with positive blood culture (n=36). An equal number of gestational-age matched asymptomatic neonates without risk factor of sepsis served as controls. Statistical validity of IL-6 was compared with sepsis screening parameters as the diagnostic marker for EOS. Gram negative organisms were the predominant cause of EOS. The most commonly isolated organism was <em>Acinetobacter baumanii</em>. The sensitivity and specificity of IL-6 with a cut-off value of 40.5 pg/mL and area under curve of 0.959 were 92.3 and 90.48%, respectively. In contrast, the sensitivity and specificity of different parameters of sepsis screening ranged from 37.5-68.75% and 47.95-57.35%, respectively. In conclusion, cord blood IL-6 can be used as a highly sensitive and specific early diagnostic marker of EOS at a cut-off concentration of 40.5 pg/mL.

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Hematologic Profiles of Ethiopian Preterm Infants With Clinical Diagnoses of Early-Onset Sepsis, Perinatal Asphyxia, and Respiratory Distress Syndrome

Global Pediatric Health ◽

10.1177/2333794x20960264 ◽

2020 ◽

Vol 7 ◽

pp. 2333794X2096026

Author(s):

Zemene Tigabu Kebede ◽

Yohannes Hailu Matebe ◽

Abayneh Girma Demisse ◽

Mulugeta Ayalew Yimer ◽

Amha Mekasha ◽

...

Keyword(s):

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Preterm Infants ◽

Early Onset ◽

Distress Syndrome ◽

Perinatal Asphyxia ◽

Platelet Counts ◽

Early Onset Sepsis ◽

Preterm Babies ◽

Hematologic Profile

Objective. To determine the hematologic profile of preterm infants with regard to different diseases. Methods. A prospective, cross-sectional, observational study, conducted in 5 hospitals in Ethiopia from July 2016 to May 2018. Preterm babies <7 days of age were included and investigated with complete blood counts (CBC) and other investigations, accordingly. Results. Out of 4919 preterms, 3852 (78.3%) were admitted to a newborn intensive care unit, and of these, 68.3% had a CBC performed. The mean values of hemoglobin, white blood cell (WBC) and platelet counts were 17.9 mg/dL; 12 685 cells/mm3, and 159 340 cells/mm3, respectively. Early onset neonatal sepsis (EONS) 1433 (37%), asphyxia 266 (6.9%), and respiratory distress syndrome (RDS) 1738 (45.3%) were common reasons for admission. The WBC count was <5000 cells/mm3 for 8.8%, 9.0%, and 11.1% of neonates with EONS, asphyxia and RDS, respectively. The hemoglobin value was <7 mg/dL for 0.6%, 1.7%, and 0.4% of preterm infants with EONS, asphyxia, and RDS, respectively. The platelet count was <50 000 cells/mm3 for 16.8%, 17.7%, and 19.8% of preterms admitted with a diagnosis of EONS, asphyxia, and RDS, respectively. Conclusion. WBC and platelet counts were the most common to be associated with EONS, asphyxia, and RDS. Further study is recommended to determine the effect of abnormal hematologic profile on the outcome of preterm babies.

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Diagnostic accuracy of interleukin-6 for early-onset sepsis in preterm neonates

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2019.1606194 ◽

2019 ◽

Vol 34 (2) ◽

pp. 253-258 ◽

Cited By ~ 1

Author(s):

Chinedu U. Ebenebe ◽

Franziska Hesse ◽

Martin E. Blohm ◽

Roman Jung ◽

Steffen Kunzmann ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Interleukin 6 ◽

Early Onset ◽

Preterm Neonates ◽

Early Onset Sepsis

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ASSOCIATION OF SERUM PROCALCITONIN LEVEL IN THE UMBILICAL CORD BLOOD OF THE NEONATES BORN WITH PERINATAL RISK FACTORS FOR EARLY-ONSET SEPSIS.

10.36106/0320035 ◽

2021 ◽

pp. 57-59

Author(s):

Somsubhra Ghosh ◽

Sibnath Gayen ◽

Debarshi Jana

Keyword(s):

Risk Factors ◽

Cord Blood ◽

Early Onset ◽

Cross Sectional Study ◽

Tertiary Referral Hospital ◽

Cross Sectional ◽

Perinatal Risk Factors ◽

Perinatal Risk ◽

Mortality And Morbidity ◽

Early Onset Sepsis

Introduction: Sepsis remains one of the most common causes of neonatal mortality and morbidity in India as also globally. Aim:To evaluate the level of procalcitonin (PCT) in the cord blood of the neonates born with perinatal risk factors for early-onset sepsis (EOS) at a tertiary referral hospital of Kolkata. Materials and methods: st An observational cross-sectional study Labour room of R G Kar Medical College & Hospital, Kolkata From February 1 , st 2019 to July 31 , 2020. Conclusion: This practice would represent a reduction of the potential toxicity in the newborns and in the development of bacterial resistances as well. However, maternal prophylactic antibiotherapy decreases the incidences of vertically transmitted neonatal infections

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