Study of Atherosclerotic Risk Factors in Patients with Prediabetes and Type II Diabetes Mellitus with Special Reference to Carotid Intima–media Thickness

2017 ◽  
Vol 3 (1) ◽  
pp. 15-19
Author(s):  
Anita Bhosale ◽  
MV Krishna ◽  
Suraj Das ◽  
M Gautam
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Special Reference ◽  
Type Ii Diabetes ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Media Thickness ◽  
Atherosclerotic Risk Factors

ABSTRACT Background The present study was carried out to study various atherosclerotic risk factors in prediabetes and type II diabetes mellitus (DM) patients, with special reference to carotid artery intima–media thickness (CIMT). The mean value of CIMT as an indicator of early atherosclerosis was determined and the various atherosclerotic risk factors in patients with prediabetes and type II DM were studied. Materials and methods A Comparative two group study was conducted involving 50 patients each with prediabetes and type 2 diabetes mellitus in the age group of 30 to 65 years, Confirmed by FPG/2hour PG/HbA1C/Random plasma glucose values according to ADA criteria, over a period of one year. The study consisted of interview regarding demographic profiles, vascular risk factors, fundoscopy and investigation like FPG, 2hour PG with OGTT, HbA1C, lipid profile, Renal function tests, urine for microalbuminuria, ECG, 2DECHO and CIMT Measurement using B mode ultrasonography. Results The association between age of the patients and occurrence of type II DM and prediabetes was found to be statistically significant. Mean duration of type II DM in our study was 6.64 ± 6.71 years. 66% Diabetics and 62% Pre-Diabetics had a BMI over 23. Mean TGs levels in diabetics and Pre-diabetics where 268 mg/dl and 193mg/dl respectively. Mean CIMT in Diabetics and Pre-diabetics were 0.81mm and 0.67mm respectively. Incidence of hypertension in diabetics and Pre-diabetics were 30% and 26% respectively. CIMT had a positive association with hypertension, smoking, and a moderate significance with alcohol use. Conclusion The present study emphasizes on the role of CIMT measurement as a routine investigation among diabetics and pre-diabetics for early recognition of atherosclerosis and cardiovascular risk reduction. How to cite this article Bhosale A, Krishna MV, Suraj D, Gautam M. Study of Atherosclerotic Risk Factors in Patients with Prediabetes and Type II Diabetes Mellitus with Special Reference to Carotid Intima–media Thickness. J Med Sci 2017;3(1):15-19.

scholarly journals Mean Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus Attending Tertiary Care Center: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (244) ◽  
pp. 1243-1246
Author(s):  
Prakash Kayastha ◽  
Sharma Paudel ◽  
Ghanshyam Gurung ◽  
Pradeep Kumar ◽  
Rudra Prasad Upadhyaya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Care Center ◽  
Tertiary Care ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Media Thickness

Introduction: Sonographic carotid intima media thickness measurement in diabetic patients is an important tool for estimating the risk of cardiovascular and cerebrovascular events. It is a simple, noninvasive and widely available tool which can give idea of further treatment needed. The objective of this study was to determine the mean intima media complex thickness in patients with type II diabetes mellitus attending a tertiary care center. Methods: This was a descriptive cross-sectional study done in 64 patients with the type II diabetes mellitus patients visiting diabetic clinic of Tribhuvan University Teaching Hospital, sent for carotid Doppler examination in the department of radiology and imaging. Ethical approval was taken from the Instituitonal Review Board. Convenient sampling method was used. Carotid intima media thickness was measured on both sides and mean intima media thickness was calculated. Mean intima media thickness for male and female diabetic patients was also calculated separately. Statistical Package for Social Sciences version 25 was used for data analysis. Results: The mean carotid intima media thickness was 0.86±0.13mm with range from 0.7mm to 1.3mm. Mean intima media thickness in male was 0.832±0.094mm and in female it was 0.904±0.144mm. Among 64 patients, 30 (46.8%) were female and 34 (53.3%) were male. Age of the patients ranged from 35 years to 68 years with mean age of 52.4±6.54 years. Conclusions: Carotid intima media thickness in patients with type II diabetes mellitus showed higher values than that of mean value from study done in similar study. Female had higher mean intima media thickness than male.

scholarly journals Role of fasting and postprandial hypertriglyceridemia and its association with carotid intima media thickness in Type II diabetes patients

2018 ◽  
Vol 7 (1) ◽  
pp. 17-22
Author(s):  
R Pathak ◽  
Prabin Adhikari ◽  
UN Pathak
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Type Ii ◽  
Media Thickness ◽  
Postprandial Triglyceride ◽  
Postprandial Hypertriglyceridemia ◽  
Carotid Bulb

Background and aim: Type 2 diabetes mellitus is associated with the development of premature arteriosclerosis and a higher cardiovascular morbidity and mortality. Diabetic dyslipidaemia is believed to play an important role in the pathogenesis of accelerated atherosclerosis in this condition. B-mode ultrasound enables non-invasive, direct visualization of the arterial wall. The aim of this study was to correlate intima media thickness of the carotid artery (CIMT) quantification as a reliable marker of atherosclerotic burden in diabetes patients.Method: It was a Cross Sectional Study done on 50 patients in the age group of 30-70 years with type II Diabetes Mellitus of more than 5 years duration without hypertension. Carotid Intima Media Thickness (CIMT) was measured using an echotomographic system with a 7.5-MHz linear transducer probe. With the carotid bulb and the longitudinal projection of the common carotid artery 2cmx from carotid bulb, the site of the greatest thickness including a plaque lesion was sought along both near and far walls bilaterally.Results: The mean CIMT of subjects with fasting triglyceride level less than 150 mg/ dL was 13.2±0.48 mm with a range of 0.6-2.4 mm. Similarly the level between 150- 200 mg/dL was 1.89±0.54 mm with a range of 1.3-2.6 mm and level more than 200 mg/dL was 2.00±0.63 mm with a range of 0.8-2.6 mm. From the present study, it is clearly evident that age, duration of disease, fasting triglycerides and postprandial triglycerides have a significant impact on the CIMT, whereas other variables are having any significant impact on CIMT.Conclusion: The present study concludes both fasting and postprandial triglyceride levels correlate significantly with carotid intima media thickness. But, the correlation of postprandial triglyceride levels with carotid intima media thickness is better than that of fasting triglyceride levels with carotid intima media thickness, the postprandial hypertriglyceridemia despite normal fasting triglyceride level can be considered as an independent risk factor for atherosclerosis in type 2 diabetes mellitus.  

scholarly journals Asymptomatic Carotid Artery Stenosis among Patients with Type II Diabetes Mellitus

2021 ◽  
Vol 11 (01) ◽  
pp. 27-30
Author(s):  
Sadia Shahid ◽  
Abdul Latif Khattak ◽  
Karamat Hussain Shah Bukhari ◽  
Raffi Uddin ◽  
Raees Iqbal Khan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Carotid Artery ◽  
Type Ii Diabetes ◽  
Leading Edge ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Asymptomatic Carotid ◽  
Media Thickness

Objectives: To assess Carotid artery intima-media thickness in patients with type II diabetes mellitus. Study design and setting: This descriptive cross-sectional study was conducted at Department of Medicine, CMH Quetta from June 2018 to May 2019. Methodology: Total 176 known type II diabetes mellitus (DM) patients were included in study. Age ranged from 30-70 years. Patients using statin drugs, chronic kidney disease and decompensated liver cirrhosis were excluded. Carotid artery ultrasonography was carried out by radiologist. Carotid artery intima-media thickness (CIMT) was achieved with a 7 MHz B-mode ultrasound system. The intima-media thickness (IMT) was demarcated as the distance between the leading edge of the luminal echo to the leading edge of the adventitia of the media. This distance was measured during the diastolic phase. This was measured 3 cm before the carotid bifurcation. Also, carotid bifurcation and internal carotid artery 2 cm distally from the carotid bifurcation was scanned. Results: Mean age was 47.86 ± 6.46 years. Most of the patients 125 (71.02%) were consisted of 30 to 50 years of age. Among them the 176 patients, 92 (52.27%) were male and 84 (47.73%) were females. Male to female ratio comprised of 1.1:1. Results further revealed that 43(24.43%) patients showed asymptomatic Carotid artery intima-media thickness. Rest there was no asymptomatic Carotid artery intima-media thickness in 133 (75.57%) patients. Conclusion: This study determined that the frequency of asymptomatic Carotid artery intima-media thickness in patients with type II diabetes mellitus is quite high.

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