Relevance of Thyroid Autoantibodies in Patients with Thyroid Dysfunction and in General Population

2018 ◽  
pp. 32-32
Author(s):  
Shailesh Pitale ◽  
Anagha Sahasrabuddhe
Keyword(s):  
General Population ◽  
Thyroid Dysfunction ◽  
Thyroid Autoantibodies

scholarly journals The association between hypoechogenicity or irregular echo pattern at thyroid ultrasonography and thyroid function in the general population

2006 ◽  
Vol 155 (4) ◽  
pp. 547-552 ◽  
Author(s):  
Pernille Vejbjerg ◽  
Nils Knudsen ◽  
Hans Perrild ◽  
Peter Laurberg ◽  
Inge Bülow Pedersen ◽  
...  
Keyword(s):  
General Population ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Overt Hypothyroidism ◽  
Thyroid Autoantibodies ◽  
Thyroid Ultrasonography ◽  
Cross Sectional ◽  
Similar Association ◽  
Serum Tsh

Objective: Patients with overt hypothyroidism show decreased echogenicity of the thyroid at ultrasonography (US). The aim of this study was to investigate the association between echogenicity of the thyroid/irregular echo pattern, and thyroid function in the general population, i.e. subjects without overt thyroid disease. Design: A cross-sectional investigation of 4649 randomly selected adult subjects. Methods: Blood samples were analysed for serum TSH, thyroid hormones and thyroid autoantibodies. US of the thyroid was performed. Results: Participants with decreased echogenicity (n=379) had a higher mean TSH (1.65 mU/l) compared with subjects with normal echogenicity (1.21 mU/l, P<0.0001). The association was stronger in subjects with markedly decreased echogenicity (4.20 mU/l, P<0.0001). A similar association was seen when the subjects were divided into subgroups according to the level of TSH; more subjects with high levels of TSH had decreased echogenicity (P<0.0001). Likewise, more subjects with high levels of TSH had an irregular echo pattern (P<0.0001). Subjects with decreased echogenicity had a higher risk of having thyroid autoantibodies than subjects without decreased echogenicity (P<0.0001). This association was stronger when echogenicity was markedly decreased. Conclusions: We demonstrated an association between hypoechogenicity at thyroid US and higher levels of serum TSH even in subjects without overt thyroid disease, suggesting decreased echogenicity as an early sign of thyroid dysfunction. Irregular echo pattern, whether accompanied by hypoechogenicity or not, was another possible marker of thyroid failure. This indicates a possible use of thyroid US in detecting early and subclinical thyroid dysfunction.

Different aetiologies in post-partum thyroiditis?

1983 ◽  
Vol 104 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Per Anders Dahlberg ◽  
Rolf Jansson
Keyword(s):  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Post Partum ◽  
Lymphocytic Infiltration ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Radioiodine Uptake ◽  
Thyroid Cytology

Abstract. During a 4 year period 19 women with post-partum onset of thyroid dysfunction have been seen in our clinic. Five women had high radioiodine uptake thyrotoxicosis (Graves' disease). Twelve women had hypothyroid symptoms starting within 3–6 months of delivery. All of these women had thyroid microsomal and/or cytoplasmic autoantibodies and thyroid lymphocytic infiltration suggesting aggravation of pre-existing subclinical autoimmune thyroiditis (Hashimoto's disease). At follow-up thyroid function gradually improved in all but signs of persistent thyroid hypofunction remained in seven. Thus women developing symptomatic postpartum hypothyroidism should be followed regularly and when thyroxine treatment is commenced in the post-partum period, it has to be continued indefinitely in many cases. Two women presented with transient low radioiodine uptake thyrotoxicosis and a small painless goitre. Thyroid cytology revealed thyroiditis but they had no thyroid autoantibodies. When followed after a succeeding delivery none of these women developed post-partum thyroid dysfunction in contrast to women in the autoimmune group. Probably the aetiology of thyroid dysfunction in these 2 women was different.

scholarly journals Mortality and Vascular Outcomes in Patients Treated for Thyroid Dysfunction

2006 ◽  
Vol 91 (6) ◽  
pp. 2159-2164 ◽  
Author(s):  
R. W. V. Flynn ◽  
T. M. MacDonald ◽  
R. T. Jung ◽  
A. D. Morris ◽  
G. P. Leese
Keyword(s):  
General Population ◽  
Thyroid Dysfunction ◽  
Population Based ◽  
Primary Hypothyroidism ◽  
Secondary Outcome ◽  
Standardized Mortality Ratio ◽  
Vascular Events ◽  
Mortality And Morbidity ◽  
Increased Risk ◽  
All Cause Mortality

Abstract Context: There are limited studies describing mortality and morbidity in patients treated for hyperthyroidism, and no data exist for people with treated hypothyroidism. Objective: The objective of the study was to describe all-cause mortality and vascular mortality and morbidity in patients after treatment for hyperthyroidism and hypothyroidism. Design: This was a population-based cohort study from 1994 to 2001. Setting: The study was conducted in Tayside, Scotland. Patients: All patients were treated for thyroid dysfunction. Intervention(s): Event rates among patients with thyroid dysfunction were compared with rates in the general population. We measured standardized mortality ratio and standardized incidence ratio (SIR). Main Outcome Measure(s): The primary outcome was all-cause mortality. The secondary outcome was serious vascular event, the composite end point of nonfatal myocardial infarction, nonfatal stroke, or vascular death. Results: There were 15,889 primary hypothyroid and 3,888 hyperthyroid patients. There were 3,116,719 patient-years of follow-up in 524,152 subjects in the general population. No increase was found in all-cause mortality or serious vascular events in patients with treated hypothyroidism or hyperthyroidism. Nonfatal ischemic heart disease [SIR 1.23, 95% confidence interval (CI) 1.10–1.36] and dysrhythmias (SIR 1.32, 95% CI 1.11–1.57) were increased in treated hypothyroidism when adjusted for age, sex, diabetic status, and previous vascular disease. In treated stabilized hyperthyroidism, only the risk of dysrhythmias was increased (SIR 2.71, 95% CI 1.63–4.24). Risk of heart failure or cerebrovascular disease was not increased in either patient group. Conclusions: We found no increase in all-cause mortality in subjects with treated thyroid disease. However, there was increased risk of cardiovascular morbidity in patients with treated primary hypothyroidism and dysrhythmias in treated hyperthyroidism.

scholarly journals Status of thyroid autoantibodies among Nigerian vitiligo patients

2018 ◽  
Vol 4 (3) ◽  
pp. 54
Author(s):  
Collins Amadi ◽  
Ehimen P. Odum
Keyword(s):  
General Population ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Chi Square ◽  
Thyroid Autoantibody ◽  
Autoimmune Thyroid ◽  
Thyroglobulin Antibody ◽  
The Status ◽  
The University

<p class="abstract"><strong>Background:</strong> The prevalence of thyroid autoantibodies among vitiligo patients is higher than the general population. This study was therefore aimed to evaluate the status of thyroid autoantibodies in Nigerian patients with vitiligo.</p><p class="abstract"><strong>Methods:</strong> A retrospective study of thyroid autoantibody test parameters of vitiligo patients who visited the Department of Chemical Pathology and Metabolic Medicine of the University of Port Harcourt Teaching Hospital between 1<sup>st</sup> January 2012 and 31<sup>st</sup> December 2016 was undertaken to evaluate the status of thyroid autoantibody. Data collected irrespective of vitiligo variant were age, sex, serum thyroid stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO) titers and thyroglobulin antibody (anti-Tg) titers. The analysis was done using Shapiro-Wilk, descriptive statistics, chi-square, and Fisher’s exact, two-sample t-test. The level of p&lt;0.05 was considered significant.  </p><p class="abstract"><strong>Results:</strong> There were a total of 102 subjects with 40 (39.2%) males and 62 (60.8%) females. Subjects’ age ranged from 4–61 with a median value of 23 years. The mean serum TSH, anti-TPO and anti-Tg were 2.6 IU/ml, 64.6 IU/ml, and 55.2 IU/ml respectively. Positive thyroid autoantibodies titers was documented in 35 (34.3%; &lt;0.001) subjects. Anti-TPO and anti-Tg positive titers were detected in 34 (33.3%) and 19 (18.6%) subjects respectively, while autoimmune thyroid disease was observed in 20 (19.6%) of the vitiligo subjects.</p><p class="abstract"><strong>Conclusions:</strong> Thyroid autoantibodies are more prevalent among vitiligo patients than the general population. Regular screening for these thyroid autoantibodies should be made compulsory in the management of patients with vitiligo.</p>

scholarly journals THYROID DYSFUNCTION IN GENERAL POPULATION OF KHYBER PAKHTUNKHWA, PAKISTAN

1969 ◽  
Vol 32 (1) ◽  
Author(s):  
Shahnaz Attaullah ◽  
Bibi Safia Haq ◽  
Mairman Muska
Keyword(s):  
General Population ◽  
Thyroid Dysfunction ◽  
Khyber Pakhtunkhwa
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