scholarly journals Association of IL28B Genotypes and Baseline Serum Interferon-γ-Inducible- Protein-10 Levels with Treatment Response in Hepatitis C Virus Patients in China

Gut and Liver ◽  
2016 ◽  
Vol 10 (3) ◽  
Author(s):  
Renwen Zhang ◽  
Cuiping Shao ◽  
Na Huo ◽  
Minran Li ◽  
Xiaoyuan Xu
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Response ◽  
Interferon Γ ◽  
Baseline Serum ◽  
Inducible Protein

scholarly journals Elevated Serum Levels of Interferon‐γ–Inducible Protein–10 in Patients Coinfected with Hepatitis C Virus and HIV

2007 ◽  
Vol 196 (7) ◽  
pp. 1053-1057 ◽  
Author(s):  
Barbara Roe ◽  
Suzie Coughlan ◽  
Jaythoon Hassan ◽  
Anne Grogan ◽  
Gillian Farrell ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Elevated Serum ◽  
Serum Levels ◽  
Interferon Γ ◽  
Inducible Protein

Relationship of interferon-γ-inducible protein-10 kDa with viral response in patients with various heterogeneities of hepatitis C virus genotype-4

2013 ◽  
Vol 25 (4) ◽  
pp. 404-410 ◽  
Author(s):  
Hamad I. Al-Ashgar ◽  
Mohammed Q. Khan ◽  
Ahmed Helmy ◽  
Sahar Al-Thawadi ◽  
Mohammed N. Al-Ahdal ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Interferon Γ ◽  
Virus Genotype ◽  
Genotype 4 ◽  
Viral Response ◽  
Inducible Protein ◽  
Relationship Of

scholarly journals Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response

Hepatology ◽  
2011 ◽  
Vol 53 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Jama M. Darling ◽  
Jeroen Aerssens ◽  
Gregory Fanning ◽  
John G. McHutchison ◽  
David B. Goldstein ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Gene Polymorphism ◽  
Treatment Response ◽  
Predictive Value ◽  
Interferon Γ ◽  
Hepatitis C Treatment ◽  
Inducible Protein ◽  
Pretreatment Serum

scholarly journals Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 610 ◽  
Author(s):  
Volker Kinast ◽  
Stefan L. Leber ◽  
Richard J. P. Brown ◽  
Gabrielle Vieyres ◽  
Patrick Behrendt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Ectopic Expression ◽  
Host Factor ◽  
Hcv Infection ◽  
Mrna Levels ◽  
Structural Support ◽  
Protein Levels ◽  
Inducible Protein

Keratin proteins form intermediate filaments, which provide structural support for many tissues. Multiple keratin family members are reported to be associated with the progression of liver disease of multiple etiologies. For example, keratin 23 (KRT23) was reported as a stress-inducible protein, whose expression levels correlate with the severity of liver disease. Hepatitis C virus (HCV) is a human pathogen that causes chronic liver diseases including fibrosis, cirrhosis, and hepatocellular carcinoma. However, a link between KRT23 and hepatitis C virus (HCV) infection has not been reported previously. In this study, we investigated KRT23 mRNA levels in datasets from liver biopsies of chronic hepatitis C (CHC) patients and in primary human hepatocytes experimentally infected with HCV, in addition to hepatoma cells. Interestingly, in each of these specimens, we observed an HCV-dependent increase of mRNA levels. Importantly, the KRT23 protein levels in patient plasma decreased upon viral clearance. Ectopic expression of KRT23 enhanced HCV infection; however, CRIPSPR/Cas9-mediated knockout did not show altered replication efficiency. Taken together, our study identifies KRT23 as a novel, virus-induced host-factor for hepatitis C virus.

scholarly journals PP-141 Predicting treatment response in hepatitis C virus infected patients: from gene to protein expression

2009 ◽  
Vol 13 ◽  
pp. S86-S87
Author(s):  
Limin Chen ◽  
Jing Sun ◽  
Maha Guindi ◽  
Jordan Feld ◽  
Jenny Heathcote ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Expression ◽  
Treatment Response
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